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Cytokine profile of anti-spike CD4+T cells predicts humoral and CD8+T cell responses after anti-SARS-CoV-2 mRNA vaccination

dc.rights.licenseopenen_US
dc.contributor.authorBENHAMOUDA, Nadine
dc.contributor.authorBESBES, Anissa
dc.contributor.authorBAUER, Rebecca
dc.contributor.authorMABROUK, Nesrine
dc.contributor.authorGADOUAS, Gauthier
dc.contributor.authorDESAINT, Corinne
dc.contributor.authorCHEVRIER, Lucie
dc.contributor.authorLEFEBVRE, Maeva
dc.contributor.authorRADENNE, Anne
dc.contributor.authorROELENS, Marie
dc.contributor.authorPARFAIT, Béatrice
dc.contributor.authorWEISKOPF, Daniela
dc.contributor.authorSETTE, Alessandro
dc.contributor.authorGRUEL, Nadège
dc.contributor.authorCOURBEBAISSE, Marie
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorAPPAY, Victor
dc.contributor.authorPAUL, Stephane
dc.contributor.authorGOROCHOV, Guy
dc.contributor.authorROPERS, Jacques
dc.contributor.authorLEBBAH, Said
dc.contributor.authorLELIEVRE, Jean-Daniel
dc.contributor.authorJOHANNES, Ludger
dc.contributor.authorULMER, Jonathan
dc.contributor.authorLEBEAUX, David
dc.contributor.authorFRIEDLANDER, Gerard
dc.contributor.authorDE LAMBALLERIE, Xavier
dc.contributor.authorRAVEL, Patrice
dc.contributor.authorKIENY, Marie Paule
dc.contributor.authorBATTEUX, Fréderic
dc.contributor.authorDURIER, Christine
dc.contributor.authorLAUNAY, Odile
dc.contributor.authorTARTOUR, Eric
dc.date.accessioned2024-11-07T08:56:40Z
dc.date.available2024-11-07T08:56:40Z
dc.date.issued2024-08
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203157
dc.description.abstractEnCoordinating immune responses – humoral and cellular – is vital for protection against severe Covid-19. Our study evaluates a multicytokine CD4+T cell signature's predictive for post-vaccinal serological and CD8+T cell responses. A cytokine signature composed of four cytokines (IL-2, TNF-α, IP10, IL-9) excluding IFN-γ, and generated through machine learning, effectively predicted the CD8+T cell response following mRNA-1273 or BNT162b2 vaccine administration. Its applicability extends to murine vaccination models, encompassing diverse immunization routes (such as intranasal) and vaccine platforms (including adjuvanted proteins). Notably, we found correlation between CD4+T lymphocyte-produced IL-21 and the humoral response. Consequently, we propose a test that offers a rapid overview of integrated immune responses. This approach holds particular relevance for scenarios involving immunocompromised patients because they often have low cell counts (lymphopenia) or pandemics. This study also underscores the pivotal role of CD4+T cells during a vaccine response and highlights their value in vaccine immunomonitoring.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enHealth sciences
dc.subject.enImmunity
dc.subject.enVirology
dc.subject.enMathematical biosciences
dc.subject.enMachine learning
dc.title.enCytokine profile of anti-spike CD4+T cells predicts humoral and CD8+T cell responses after anti-SARS-CoV-2 mRNA vaccination
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.isci.2024.110441en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed39104410en_US
bordeaux.journaliScienceen_US
bordeaux.volume27en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04770811
hal.version1
hal.date.transferred2024-11-07T08:56:46Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=iScience&rft.date=2024-08&rft.volume=27&rft.issue=8&rft.au=BENHAMOUDA,%20Nadine&BESBES,%20Anissa&BAUER,%20Rebecca&MABROUK,%20Nesrine&GADOUAS,%20Gauthier&rft.genre=article


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