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Regression of cervical high-grade squamous intraepithelial lesions (HSIL/CIN2) managed expectantly.

dc.rights.licenseopenen_US
dc.contributor.authorNOURRISSON, Audrey
dc.contributor.authorLEPETIT, Helene
dc.contributor.authorMARTY, Marion
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorGARRIGUE, Isabelle
IDREF: 12258953X
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorBRUN, Jean-Luc
dc.date.accessioned2024-11-05T12:53:58Z
dc.date.available2024-11-05T12:53:58Z
dc.date.issued2022-10-01
dc.identifier.issn2468-7847en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203125
dc.description.abstractEnMany women with cervical high-grade squamous intraepithelial lesions (HSIL/CIN2) are managed expectantly, because about half of them will regress spontaneously, thus avoiding systematic loop electrosurgical excision procedure and related adverse effects. However, most of the guidelines have restricted this strategy to the youngest women. The objectives of our study were to determine the rate and the predictors of regression of HSIL/CIN2 managed expectantly. This retrospective study included 128 patients under 40 years of age (median 29, range 21-39), and HSIL/CIN2 diagnosed by biopsy between 2012 and 2019. They were followed-up without treatment in the department of gynecology at Bordeaux University Hospital, France. The regression of HSIL/CIN2 was defined by the regression or the disappearance of initial colposcopic findings, cytological and/or histological results. The lesion spontaneously regressed or disappeared in 76 (59%) patients during a median follow-up of 25 months (range, 7-86). In the multivariable analysis, minor change at colposcopy (odds ratio OR = 2.8 (CI95% 1.2-6.9), P = 0.02), low grade lesions (ASC-US/LSIL) by cytology (OR = 4.1 (CI95% 1.7-10.1), P < 0.001), and infection by HPV other than HPV-16 (OR = 5.4 (CI95% 2.3-13.9), P < 0.001) predicted the spontaneous regression of HSIL/CIN2. Colposcopic findings, cytological results, and HPV genotyping, but not the age, were baseline factors predicting the evolution of HSIL/CIN2 in patients under 40.
dc.language.isoENen_US
dc.subject.enFemale
dc.subject.enHumans
dc.subject.enPapillomavirus Infections
dc.subject.enRetrospective Studies
dc.subject.enSquamous Intraepithelial Lesions
dc.subject.enUterine Cervical Neoplasms
dc.subject.enUterine Cervical Dysplasia
dc.title.enRegression of cervical high-grade squamous intraepithelial lesions (HSIL/CIN2) managed expectantly.
dc.title.alternativeJ Gynecol Obstet Hum Reproden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jogoh.2022.102442en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
dc.identifier.pubmed35842125en_US
bordeaux.journalJournal of Gynecology Obstetrics and Human Reproductionen_US
bordeaux.page102442en_US
bordeaux.volume51en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue8en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04767377
hal.version1
hal.date.transferred2024-11-05T12:54:01Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Gynecology%20Obstetrics%20and%20Human%20Reproduction&amp;rft.date=2022-10-01&amp;rft.volume=51&amp;rft.issue=8&amp;rft.spage=102442&amp;rft.epage=102442&amp;rft.eissn=2468-7847&amp;rft.issn=2468-7847&amp;rft.au=NOURRISSON,%20Audrey&amp;LEPETIT,%20Helene&amp;MARTY,%20Marion&amp;GARRIGUE,%20Isabelle&amp;BRUN,%20Jean-Luc&amp;rft.genre=article


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