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Hair cortisol concentrations across pregnancy and maternal postpartum depressive symptoms - The ELFE cohort

dc.rights.licenseopenen_US
hal.structure.identifierInstitut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
dc.contributor.authorMAGUET, Charlotte
hal.structure.identifierInstitut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
dc.contributor.authorDOWNES, Naomi
hal.structure.identifierInstitut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
dc.contributor.authorMARR, Ketevan
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSUTTER-DALLAY, Anne-Laure
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGALERA, Cedric
ORCID: 0000-0003-0549-9608
IDREF: 110034007
hal.structure.identifierInstitut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
dc.contributor.authorWALLEZ, Solène
hal.structure.identifierTechnische Universität Dresden = Dresden University of Technology [TU Dresden]
dc.contributor.authorKIRSCHBAUM, Clemens
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorGRESSIER, Florence
hal.structure.identifierInstitut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
dc.contributor.authorMELCHIOR, Maria
hal.structure.identifierCentre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques [CRESS (U1153 / UMR_A 1125)]
dc.contributor.authorCHARLES, Marie-Aline
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorKOEHL, Muriel
hal.structure.identifierInstitut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
dc.contributor.authorVAN DER WAERDEN, Judith
dc.date.accessioned2024-10-31T13:38:20Z
dc.date.available2024-10-31T13:38:20Z
dc.date.issued2024-10-01
dc.identifier.issn0022-3956en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203082
dc.description.abstractEnPostpartum depression and depressive symptoms have a major impact on maternal and infant health and wellbeing, yet to date their aetiology remains unclear. One hypothesis suggests a link between these symptoms and variations in prenatal cortisol levels, but existing evidence is limited and inconclusive. This study aims to provide additional evidence to disentangle the relationship between prenatal cortisol concentrations and subsequent occurrence of postpartum depressive symptoms. Cortisol for all three trimesters of pregnancy was extracted from the hair of 775 women participating in the French ELFE cohort. Depressive symptomatology at two months postpartum was assessed through the Edinburgh Postpartum Depression Scale (EPDS). Associations between prenatal cortisol levels and EPDS scores were tested using propensity-score weighted logistic regression models to control for confounders. An increase in mean cortisol concentrations was observed from the first to the third trimester of pregnancy.No significant differences in hair cortisol concentrations were found during the first and second trimesters between women who experienced postpartum depressive symptoms and those who did not. However, an association was observed between third trimester hair cortisol concentrations and depressive symptoms at two months postpartum. Women whose cortisol concentrations fell within the second quartile had a higher risk of subsequent PPDS (aOR = 2.67, 95%CI [1.01, 7.08]).Using a large sample from the general population, we observed an association between hair cortisol levels during the third trimester of pregnancy and postpartum depressive symptoms. Nevertheless, our results suggest that future studies could benefit from investigating other biomarkers of the reactivity of the corticotropic axis.
dc.description.sponsorshipPlateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssanceen_US
dc.description.sponsorshipResarch platform on cohorts of children followed from birth - ANR-19-COHO-0001en_US
dc.description.sponsorshipPsychopathologie parentale et développement des enfants - ANR-17-CE36-0002en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enHair cortisol
dc.subject.enPerinatal period
dc.subject.enPostpartum depressive symptoms
dc.title.enHair cortisol concentrations across pregnancy and maternal postpartum depressive symptoms - The ELFE cohort
dc.title.alternativeJ Psychiatr Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jpsychires.2024.08.032en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39182445en_US
bordeaux.journalJournal of Psychiatric Researchen_US
bordeaux.page305-312en_US
bordeaux.volume178en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04687870
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Psychiatric%20Research&rft.date=2024-10-01&rft.volume=178&rft.spage=305-312&rft.epage=305-312&rft.eissn=0022-3956&rft.issn=0022-3956&rft.au=MAGUET,%20Charlotte&DOWNES,%20Naomi&MARR,%20Ketevan&SUTTER-DALLAY,%20Anne-Laure&GALERA,%20Cedric&rft.genre=article


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