A multinational survey of risk factors for infection with extended-spectrum beta-lactamase-producing enterobacteriaceae in nonhospitalized patients.
| dc.rights.license | open | en_US |
| dc.contributor.author | BEN-AMI, Ronen | |
| dc.contributor.author | RODRÍGUEZ-BAÑO, Jesús | |
| dc.contributor.author | ARSLAN, Hande | |
| dc.contributor.author | PITOUT, Johann D D | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | QUENTIN, Claudine | |
| dc.contributor.author | CALBO, Esther S | |
| dc.contributor.author | AZAP, Ozlem K | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | ARPIN, Corinne
IDREF: 093324626 | |
| dc.contributor.author | PASCUAL, Alvaro | |
| dc.contributor.author | LIVERMORE, David M | |
| dc.contributor.author | GARAU, Javier | |
| dc.contributor.author | CARMELI, Yehuda | |
| dc.date.accessioned | 2024-10-30T14:36:02Z | |
| dc.date.available | 2024-10-30T14:36:02Z | |
| dc.date.issued | 2009-09-01 | |
| dc.identifier.issn | 1537-6591 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/203001 | |
| dc.description.abstractEn | Infections caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae are increasing in frequency and are associated with high mortality rates. Circulation of CTX-M-type ESBLs in the community is of particular concern, because it may confound standard infection-control measures. We analyzed the results of epidemiologic studies of infection caused by ESBL-producing Enterobacteriaceae in nonhospitalized patients from 6 centers in Europe, Asia, and North America. Risk factors for infection with an ESBL-producing organism were identified by univariate and multivariate analyses. A total of 983 patient-specific isolates were reviewed (890 [90.5%] of which were Escherichia coli, 68 [6.9%] of which were Klebsiella species, and 25 [2.5%] of which were Proteus mirabilis); 339 [34.5%] of the isolates produced ESBLs. CTX-M types were the most frequent ESBLs (accounting for 65%). Rates of co-resistance to ciprofloxacin among ESBL-producing isolates were high (>70%), but significant variation was seen among centers with respect to rates of resistance to gentamicin, amoxicillin-clavulanate, and trimethoprim-sulfamethoxazole. Similar risk factors for infection with an ESBL-producing organism were found in the different participating centers. Significant risk factors, identified by multivariate analysis, were recent antibiotic use, residence in a long-term care facility, recent hospitalization, age 65 years, and male sex (area under the receiver-operator characteristic [ROC] curve, 0.80). However, 34% of ESBL-producing isolates (115 of 336 isolates) were obtained from patients with no recent health care contact; the area under the ROC curve for the multivariate model for this group of patients was only 0.70, which indicated poorer predictive value. Community-acquired ESBL-producing Enterobacteriaceae are now prevalent worldwide, necessitating international collaboration. Novel approaches are required to adequately address issues such as empirical treatment for severe community-acquired infection and infection control. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Community-Acquired Infections | |
| dc.subject.en | Enterobacteriaceae | |
| dc.subject.en | Enterobacteriaceae Infections | |
| dc.subject.en | Female | |
| dc.subject.en | Global Health | |
| dc.subject.en | Health Surveys | |
| dc.subject.en | Humans | |
| dc.subject.en | Male | |
| dc.subject.en | Microbial Sensitivity Tests | |
| dc.subject.en | Multivariate Analysis | |
| dc.subject.en | Prevalence | |
| dc.subject.en | ROC Curve | |
| dc.subject.en | Risk Factors | |
| dc.subject.en | beta-Lactam Resistance | |
| dc.subject.en | beta-Lactamases | |
| dc.title.en | A multinational survey of risk factors for infection with extended-spectrum beta-lactamase-producing enterobacteriaceae in nonhospitalized patients. | |
| dc.title.alternative | Clin Infect Dis | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1086/604713 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie | en_US |
| dc.identifier.pubmed | 19622043 | en_US |
| bordeaux.journal | Clinical Infectious Diseases | en_US |
| bordeaux.page | 682-90 | en_US |
| bordeaux.volume | 49 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical%20Infectious%20Diseases&rft.date=2009-09-01&rft.volume=49&rft.issue=5&rft.spage=682-90&rft.epage=682-90&rft.eissn=1537-6591&rft.issn=1537-6591&rft.au=BEN-AMI,%20Ronen&RODR%C3%8DGUEZ-BA%C3%91O,%20Jes%C3%BAs&ARSLAN,%20Hande&PITOUT,%20Johann%20D%20D&QUENTIN,%20Claudine&rft.genre=article |
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