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Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults

dc.rights.licenseopenen_US
hal.structure.identifierWashington University School of Medicine [Saint Louis, MO]
dc.contributor.authorAGGARWAL, Geetika
hal.structure.identifierWashington University School of Medicine [Saint Louis, MO]
dc.contributor.authorMORLEY, John
dc.contributor.authorVELLAS, Bruno
hal.structure.identifierWashington University School of Medicine [Saint Louis, MO]
dc.contributor.authorNGUYEN, Andrew
hal.structure.identifierInternational Centre for Radio Astronomy Research [ICRAR]
dc.contributor.authorBUTLER, Andrew
dc.contributor.authorGUYONNET, Sophie
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
dc.contributor.authorCARRIÉ, Isabelle
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
dc.contributor.authorBRIGITTE, Lauréane
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
dc.contributor.authorFAISANT, Catherine
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
dc.contributor.authorLALA, Françoise
hal.structure.identifierUniversité Toulouse III - Paul Sabatier [UT3]
dc.contributor.authorDELRIEU, Julien
hal.structure.identifierPôle Gériatrie [CHU Toulouse]
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorVILLARS, Hélène
dc.contributor.authorCOMBROUZE, Emeline
dc.contributor.authorBADUFLE, Carole
dc.contributor.authorZUERAS, Audrey
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorANDRIEU, Sandrine
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
dc.contributor.authorCANTET, Christelle
hal.structure.identifierLaboratoire Eau Environnement et Systèmes Urbains [LEESU]
hal.structure.identifierIUT - Sénart Fontainebleau, 36 Rue Georges Charpak, 77567 Lieusaint
dc.contributor.authorMORIN, Christophe
dc.contributor.authorVAN KAN, Gabor
hal.structure.identifierUniversité Paris Descartes - École de sages-femmes Baudelocque [UPD ESF Baudelocque]
dc.contributor.authorDUPUY, Charlotte
dc.contributor.authorROLLAND, Yves
hal.structure.identifierInstitut de Recherche sur les CERamiques [IRCER]
dc.contributor.authorCAILLAUD, Céline
dc.contributor.authorOUSSET, Pierre-Jean
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
dc.contributor.authorLALA, Françoise
hal.structure.identifierUniversity of Washington [Seattle]
dc.contributor.authorWILLIS, Sherry
hal.structure.identifierCentre de recherche de l'Institut universitaire de gériatrie de Montreal [CRIUGM]
dc.contributor.authorBELLEVILLE, Sylvie
hal.structure.identifierCentre de recherche de l'Institut universitaire de gériatrie de Montreal [CRIUGM]
dc.contributor.authorGILBERT, Brigitte
dc.contributor.authorFONTAINE, Francine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
dc.contributor.authorMARCET, Isabelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELVA, Fleur
dc.contributor.authorFOUBERT, Alexandra
dc.contributor.authorCERDA, Sandrine
dc.contributor.authorCOSTES, Corinne
hal.structure.identifierÉcole nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique [ONIRIS]
hal.structure.identifierLaboratoire de génie des procédés - environnement - agroalimentaire [GEPEA]
hal.structure.identifierOptimisation - Système - Energie [GEPEA-OSE]
dc.contributor.authorROUAUD, Olivier
hal.structure.identifierCentre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand [CHU Dijon]
dc.contributor.authorMANCKOUNDIA, Patrick
hal.structure.identifierCHU Dijon
dc.contributor.authorQUIPOURT, Valérie
hal.structure.identifierService de médecine gériatrique (CHU de Dijon - Centre gériatrique de Champmaillot - EHPAD)
dc.contributor.authorMARILIER, Sophie
hal.structure.identifierCabinet médical [Dijon]
dc.contributor.authorFRANON, Evelyne
dc.contributor.authorBORIES, Lawrence
dc.contributor.authorPADER, Marie-Laure
dc.contributor.authorBASSET, Marie-France
dc.contributor.authorLAPOUJADE, Bruno
dc.contributor.authorFAURE, Valérie
dc.contributor.authorTONG, Michael
dc.contributor.authorMALICK-LOISEAU, Christine
dc.contributor.authorCAZABAN-CAMPISTRON, Evelyne
dc.contributor.authorDESCLAUX, Françoise
dc.contributor.authorBLATGE, Colette
dc.contributor.authorDANTOINE, Thierry
dc.contributor.authorLAUBARIE-MOURET, Cécile
dc.contributor.authorSAULNIER, Isabelle
dc.contributor.authorCLÉMENT, Jean-Pierre
dc.contributor.authorPICAT, Marie-Agnès
dc.contributor.authorBERNARD-BOURZEIX, Laurence
dc.contributor.authorWILLEBOIS, Stéphanie
dc.contributor.authorDÉSORMAIS, Iléana
dc.contributor.authorCARDINAUD, Noëlle
dc.contributor.authorBONNEFOY, Marc
dc.contributor.authorLIVET, Pierre
dc.contributor.authorREBAUDET, Pascale
dc.contributor.authorGÉDÉON, Claire
dc.contributor.authorBURDET, Catherine
dc.contributor.authorTERRACOL, Flavien
dc.contributor.authorPESCE, Alain
dc.contributor.authorROTH, Stéphanie
dc.contributor.authorCHAILLOU, Sylvie
dc.contributor.authorLOUCHART, Sandrine
dc.contributor.authorSUDRES, Kristel
dc.contributor.authorLEBRUN, Nicolas
dc.contributor.authorBARRO-BELAYGUES, Nadège
dc.contributor.authorTOUCHON, Jacques
dc.contributor.authorBENNYS, Karim
dc.contributor.authorGABELLE, Audrey
dc.contributor.authorROMANO, Aurélia
dc.contributor.authorTOUATI, Lynda
dc.contributor.authorMARELLI, Cécilia
dc.contributor.authorPAYS, Cécile
dc.contributor.authorROBERT, Philippe
dc.contributor.authorLE DUFF, Franck
dc.contributor.authorGERVAIS, Claire
dc.contributor.authorGONFRIER, Sébastien
dc.contributor.authorGASNIER, Yannick
dc.contributor.authorBORDES, Serge
dc.contributor.authorBEGORRE, Danièle
dc.contributor.authorCARPUAT, Christian
dc.contributor.authorKHALES, Khaled
dc.contributor.authorLEFEBVRE, Jean-François
dc.contributor.authorEL IDRISSI, Samira
dc.contributor.authorSKOLIL, Pierre
dc.contributor.authorSALLES, Jean-Pierre
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorLEHÉRICY, Stéphane
dc.contributor.authorCHUPIN, Marie
dc.contributor.authorMANGIN, Jean-François
dc.contributor.authorBOUHAYIA, Ali
dc.contributor.authorALLARD, Michèle
dc.contributor.authorRICOLFI, Frédéric
dc.contributor.authorDUBOIS, Dominique
dc.contributor.authorMARTEL, Marie
dc.contributor.authorCOTTON, François
dc.contributor.authorBONAFÉ, Alain
dc.contributor.authorCHANALET, Stéphane
dc.contributor.authorHUGON, Françoise
dc.contributor.authorBONNEVILLE, Fabrice
dc.contributor.authorCOGNARD, Christophe
dc.contributor.authorCHOLLET, François
dc.contributor.authorPAYOUX, Pierre
dc.contributor.authorVOISIN, Thierry
hal.structure.identifierUniversité Toulouse III - Paul Sabatier [UT3]
hal.structure.identifierCentre d'Epidémiologie et de Recherche en santé des POPulations [CERPOP]
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorDELRIEU, Julien
dc.contributor.authorPEIFFER, Sophie
dc.contributor.authorHITZEL, Anne
dc.contributor.authorALLARD, Michèle
dc.contributor.authorZANCA, Michel
dc.contributor.authorMONTEIL, Jacques
dc.contributor.authorDARCOURT, Jacques
dc.contributor.authorMOLINIER, Laurent
dc.contributor.authorDERUMEAUX, Hélène
dc.contributor.authorCOSTA, Nadège
dc.contributor.authorPERRET, Bertrand
dc.contributor.authorVINEL, Claire
dc.contributor.authorCASPAR-BAUGUIL, Sylvie
dc.contributor.authorOLIVIER-ABBAL, Pascale
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorANDRIEU, Sandrine
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
hal.structure.identifierCentre d'Epidémiologie et de Recherche en santé des POPulations [CERPOP]
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorCANTET, Christelle
dc.contributor.authorCOLEY, Nicola
dc.date.accessioned2024-10-30T14:23:42Z
dc.date.available2024-10-30T14:23:42Z
dc.date.issued2023-05-26
dc.identifier.issn2509-2715en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202998
dc.description.abstractEnAbstract The secreted peptide adropin is highly expressed in human brain tissues and correlates with RNA and proteomic risk indicators for dementia. Here we report that plasma adropin concentrations predict risk for cognitive decline in the Multidomain Alzheimer Preventive Trial (ClinicalTrials.gov Identifier, NCT00672685; mean age 75.8y, SD = 4.5 years, 60.2% female, n = 452). Cognitive ability was evaluated using a composite cognitive score (CCS) that assessed four domains: memory, language, executive function, and orientation. Relationships between plasma adropin concentrations and changes in CCS (∆CCS) were examined using Cox Proportional Hazards Regression, or by grouping into tertiles ranked low to high by adropin values and controlling for age, time between baseline and final visits, baseline CCS, and other risk factors (e.g., education, medication, APOE4 status). Risk of cognitive decline (defined as a ∆CCS of − 0.3 or more) decreased with increasing plasma adropin concentrations (hazard ratio = 0.873, 95% CI 0.780–0.977, P = 0.018). Between adropin tertiles, ∆CCS was significantly different ( P = 0.01; estimated marginal mean ± SE for the 1st to 3rd tertile, − 0.317 ± 0.064; − 0.275 ± 0.063; − 0.042 ± 0.071; n = 133,146, and 130, respectively; P < 0.05 for 1st vs. 2nd and 3rd adropin tertiles). Normalized plasma Aß 42/40 ratio and plasma neurofilament light chain, indicators of neurodegeneration, were significantly different between adropin tertile. These differences were consistent with reduced risk of cognitive decline with higher plasma adropin levels. Overall, these results suggest cognitive decline is reduced in community-dwelling older adults with higher circulating adropin levels. Further studies are needed to determine the underlying causes of the relationship and whether increasing adropin levels can delay cognitive decline.
dc.language.isoENen_US
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enAdropin
dc.subject.enCognitive decline
dc.subject.enDementia
dc.subject.enPlasma biomarkers
dc.subject.enAging
dc.title.enLow circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s11357-023-00824-3en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37233882en_US
bordeaux.journalGeroScienceen_US
bordeaux.page897-911en_US
bordeaux.volume46en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04492066
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=GeroScience&amp;rft.date=2023-05-26&amp;rft.volume=46&amp;rft.issue=1&amp;rft.spage=897-911&amp;rft.epage=897-911&amp;rft.eissn=2509-2715&amp;rft.issn=2509-2715&amp;rft.au=AGGARWAL,%20Geetika&amp;MORLEY,%20John&amp;VELLAS,%20Bruno&amp;NGUYEN,%20Andrew&amp;BUTLER,%20Andrew&amp;rft.genre=article


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