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Histone Deacetylase Inhibitors Delivery using Nanoparticles with Intrinsic Passive Tumor Targeting Properties for Tumor Therapy

dc.rights.licenseopen
hal.structure.identifierInstitut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]
dc.contributor.authorEL BAHHAJ, Fatima
hal.structure.identifierCentre de Recherche en Cancérologie Nantes-Angers [CRCNA]
dc.contributor.authorDENIS, Iza
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 1 LCPO : Polymerization Catalyses & Engineering
dc.contributor.authorLOIC, Pichavant
hal.structure.identifierInstitut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]
dc.contributor.authorDELATOUCHE, Régis
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 1 LCPO : Polymerization Catalyses & Engineering
dc.contributor.authorCOLLETTE, Floraine
hal.structure.identifierCentre de Recherche en Cancérologie Nantes-Angers [CRCNA]
dc.contributor.authorLINOT, Camille
hal.structure.identifierCentre de Recherche en Cancérologie Nantes-Angers [CRCNA]
dc.contributor.authorPOULIQUEN, Daniel
hal.structure.identifierCentre de Recherche en Cancérologie Nantes-Angers [CRCNA]
dc.contributor.authorGRÉGOIRE, Marc
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 1 LCPO : Polymerization Catalyses & Engineering
dc.contributor.authorHÉROGUEZ, Valérie
hal.structure.identifierCentre de Recherche en Cancérologie Nantes-Angers [CRCNA]
hal.structure.identifierRéseau épigénétique
dc.contributor.authorBLANQUART, Christophe
hal.structure.identifierInstitut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]
hal.structure.identifierRéseau épigénétique
dc.contributor.authorBERTRAND, Philippe
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2016
dc.identifier.issn1838-7640
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20281
dc.description.abstractEnFast clearance, metabolism and systemic toxicity are major limits for the clinical use of anti-cancer drugs. Histone deacetylase inhibitors (HDACi) present these defects despite displaying promising anti-tumor properties on tumor cells in vitro and in in vivo model of cancers. Specific delivery of anti-cancer drugs into the tumor should improve their clinical benefit by limiting systemic toxicity and by increasing the anti-tumor effect. In this work, we describe a simple and flexible polymeric nanoparticle platform highly targeting the tumor in vivo and triggering impressive tumor weight reduction when functionalized with HDACi. Our nanoparticles were produced by Ring Opening Metathesis Polymerization of azido-polyethylene oxide-norbornene macromonomers and functionalized using click chemistry. Using an orthotopic model of peritoneal invasive cancer, a highly selective accumulation of the particles in the tumor was obtained. A combination of epigenetic drugs involving a pH-responsive histone deacetylase inhibitor (HDACi) polymer conjugated to these particles gave 80% reduction of tumor weight without toxicity whereas the free HDACi has no effect. Our work demonstrates that the use of a nanovector with theranostic properties leads to an optimized delivery of potent HDACi in tumor and then, to an improvement of their anti-tumor properties in vivo.
dc.language.isoen
dc.publisherIvyspring International Publisher
dc.subject.encancer
dc.subject.entheranostics
dc.subject.enpolymeric nanoparticle
dc.subject.enperitoneal
dc.subject.enHDAC
dc.subject.enepigenetic
dc.subject.enmesothelioma
dc.title.enHistone Deacetylase Inhibitors Delivery using Nanoparticles with Intrinsic Passive Tumor Targeting Properties for Tumor Therapy
dc.typeArticle de revue
dc.identifier.doi10.7150/thno.13725
dc.subject.halSciences du Vivant [q-bio]/Cancer
bordeaux.journalTheranostics
bordeaux.page795-807
bordeaux.volume6
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue6
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierinserm-01299450
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-01299450v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Theranostics&rft.date=2016&rft.volume=6&rft.issue=6&rft.spage=795-807&rft.epage=795-807&rft.eissn=1838-7640&rft.issn=1838-7640&rft.au=EL%20BAHHAJ,%20Fatima&DENIS,%20Iza&LOIC,%20Pichavant&DELATOUCHE,%20R%C3%A9gis&COLLETTE,%20Floraine&rft.genre=article


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