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Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases

dc.rights.licenseopenen_US
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorWIEDEMANN, Aurélie
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
dc.contributor.authorLHOMME, Edouard
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHUCHON, Melanie
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorFOUCAT, Emile
hal.structure.identifierAlliance for International medical Action [ALIMA]
dc.contributor.authorBÉRERD-CAMARA, Marion
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorGUILLAUMAT, Lydia
hal.structure.identifierAlliance for International medical Action [ALIMA]
dc.contributor.authorYARADOUNO, Marcel
hal.structure.identifierAlliance for International medical Action [ALIMA]
dc.contributor.authorTAMBALOU, Jacqueline
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorRODRIGUES, Cécile
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorRIBEIRO, Alexandre
hal.structure.identifierCentre National de Formation et de Recherche en Santé Rurale [Maférinyah, Guinée] [CNFRSR]
dc.contributor.authorBÉAVOGUI, Abdoul Habib
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorLACABARATZ, Christine
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIÉBAUT, Rodolphe
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRICHERT, Laura
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorLÉVY, Yves
dc.contributor.authorABOULHAB, Jamila
dc.contributor.authorAGUIRRE-MACKENZIE, Michelle
dc.contributor.authorAKOO, Pauline
dc.contributor.authorAKPA, Esther
dc.contributor.authorAKPATA, Robert
dc.contributor.authorALBERT, Sara
dc.contributor.authorALE, Boni Maxime
dc.contributor.authorALIMAMY-BANGURA, Serry
dc.contributor.authorANDONG, Pierre
dc.contributor.authorANDREWS, Benetta
dc.contributor.authorANOMA, Stephane
dc.contributor.authorATRI, Negin
dc.contributor.authorAUGIER, Augustin
dc.contributor.authorAWUONDO, Ken
dc.contributor.authorAYOUBA, Ahidjo
dc.contributor.authorBADIO, Moses
dc.contributor.authorBAGAYOKO, Aminata
dc.contributor.authorBALDE, Abby
dc.contributor.authorBALSSA, Joséphine
dc.contributor.authorBANGURA, Lamin Molecule
dc.contributor.authorBARRINGTON, Kesha
dc.contributor.authorDE SAINT FARE, Eric Barte
dc.contributor.authorBASELER, Beth
dc.contributor.authorBAUDER, Ali
dc.contributor.authorBAUDUIN, Claire
dc.contributor.authorBAWO, Luke
dc.contributor.authorBEAVOGUI, Abdoul Habib
dc.contributor.authorBELSON, Michael
dc.contributor.authorBEN-FARHAT, Safaa
dc.contributor.authorBERERD, Marion
dc.contributor.authorBERNAUD, Nicolas
dc.contributor.authorBEYSLOW, Teedoh
dc.contributor.authorBIAI, Neirade
dc.contributor.authorBILLIOUX, Jeanne
dc.contributor.authorBILLOUIN-FRAZIER, Shere
dc.contributor.authorBINACHON, Blandine
dc.contributor.authorBLIE, Julie
dc.contributor.authorBOCKSTAL, Viki
dc.contributor.authorBOISON, Patricia
dc.contributor.authorBOLAY, Fatorma
dc.contributor.authorBOLY, Aliou
dc.contributor.authorBONAWITZ, Rachael Elizabeth
dc.contributor.authorBORG, Anne-Gaëlle
dc.contributor.authorBOSOMPEM, Samuel
dc.contributor.authorBOZMAN, Courtney
dc.contributor.authorBRADY, Tyler
dc.contributor.authorBROWNE, Sarah
dc.contributor.authorBULLIS, Ryan
dc.contributor.authorCAGNIARD, Barbara
dc.contributor.authorCAHILL, Kelly
dc.contributor.authorCAI, Yingyun
dc.contributor.authorCAMARA, Aissata Abdoulaye
dc.contributor.authorCAMARA, Aboubacar Keira
dc.contributor.authorCAMARA, Alseny Modet
dc.contributor.authorCAMPAGNE, Antoine
dc.contributor.authorCAMPION, Cécilia
dc.contributor.authorCANTAN, Alexandre
dc.contributor.authorCASH, Jennifer
dc.contributor.authorCHAI, Siew Pin
dc.contributor.authorCHAMBELIN, Francois
dc.contributor.authorCHEA, Michael
dc.contributor.authorCHÊNE, Geneviève
dc.contributor.authorCHOI, Edouard
dc.contributor.authorCHOUINARD, Michelle
dc.contributor.authorCHUNG, Florence
dc.contributor.authorCHUNG, Lucy
dc.contributor.authorCIANCIA, Séverine
dc.contributor.authorCISSE, Papa Ndiaga
dc.contributor.authorCLINE-COLE, Elfrida
dc.contributor.authorCOLIN, Céline
dc.contributor.authorCOLLER, Beth-Ann
dc.contributor.authorCONDE, Djélikan Siaka
dc.contributor.authorCONE, Katherine
dc.contributor.authorCONNOR, Laurie
dc.contributor.authorCONNOR, Nicholas
dc.contributor.authorCOOPER, Joseph Boye
dc.contributor.authorCOUFFIN-CARDIERGUES, Sandrine
dc.contributor.authorCOULIBALY, Fatoumata
dc.contributor.authorCOULIBALY, Mariam
dc.contributor.authorCREW, Page
dc.contributor.authorDABAKUYO-YONLI, Sandrine
dc.contributor.authorDABITAO, Djeneba
dc.contributor.authorDAMERVAL, Thierry
dc.contributor.authorDAVIS, Bionca
dc.contributor.authorDEEN, Gibrilla Fadlu
dc.contributor.authorDEKEYSTER, Eline
dc.contributor.authorDELFRAISSY, Jean-François
dc.contributor.authorDELMAS, Christelle
dc.contributor.authorDIAKITE, Mahamadou
dc.contributor.authorDIALLO, Alpha
dc.contributor.authorDIALLO, Fatoumata Abdoulaye
dc.contributor.authorDIALLO, Mamadou Saliou
dc.contributor.authorDIARRA, Ayouba
dc.contributor.authorDIARRA, Samba
dc.contributor.authorDIAWARA, Oualy
dc.contributor.authorDIGHERO-KEMP, Bonnie
dc.contributor.authorDIOP, Samba
dc.contributor.authorDIOUF, Waly
dc.contributor.authorDIXIT, Saurabh
dc.contributor.authorDJENABOU, Barry
dc.contributor.authorDOEPEL, Laurie
dc.contributor.authorD’ORTENZIO, Eric
dc.contributor.authorDOUMBIA, Seydou
dc.contributor.authorDOUMBIA, Moussa Moise
dc.contributor.authorDOUOGUIH, Macaya
dc.contributor.authorDOZIER, Nelson
dc.contributor.authorCAUWELAERT, Natasha Dubois
dc.contributor.authorDUCHÊNE, Alain
dc.contributor.authorDUVENHAGE, Michael
dc.contributor.authorECKES, Risa
dc.contributor.authorELLIOTT, Elizabeth
dc.contributor.authorENRIA, Luisa
dc.contributor.authorESPÉROU, Hélène
dc.contributor.authorETIENNE, Cécile
dc.contributor.authorEYLER, Allison
dc.contributor.authorFAKOLI, Lawrence
dc.contributor.authorFALLAH, Mosoka
dc.contributor.authorFAUVEL, Marie-Alix
dc.contributor.authorFAYE, Sylvain
dc.contributor.authorFAYIAH, John
dc.contributor.authorFLECK, Suzanne
dc.contributor.authorFOFANA, Vemy
dc.contributor.authorTCHOS, Karine Fouth
dc.contributor.authorFRANKLIN, Kokulo
dc.contributor.authorFUSCO, Daniela
dc.contributor.authorGADDAH, Auguste
dc.contributor.authorGAIGNET, Marylène
dc.contributor.authorGALLAGHER, Katherine
dc.contributor.authorGARDNER, Julie
dc.contributor.authorGICHINI, Harrison
dc.contributor.authorGOZALBES, Julia Garcia
dc.contributor.authorGRANDITS, Greg
dc.contributor.authorGRAY, Maima
dc.contributor.authorGREENWOOD, Brian
dc.contributor.authorGROBLER, Nico
dc.contributor.authorGROSS, Robin
dc.contributor.authorGRUE, Louis
dc.contributor.authorGRUND, Birgit
dc.contributor.authorGUINDO, Oumar
dc.contributor.authorGUPTA, Swati
dc.contributor.authorHAIDARA, Fadima
dc.contributor.authorHAMZÉ, Benjamin
dc.contributor.authorHANCOX, Emma
dc.contributor.authorHÉBERT, Jean-Christophe
dc.contributor.authorHENDRIKS, Jenny
dc.contributor.authorHENSLEY, Patricia
dc.contributor.authorHENSLEY, Lisa
dc.contributor.authorHERPIN, Betsey
dc.contributor.authorHIGGS, Elisabeth
dc.contributor.authorHILTON, Trudi
dc.contributor.authorHNEINO, Mickael
dc.contributor.authorHÖELTERMANNL, Tracey-Ann
dc.contributor.authorHOLLEY, Horace Preston
dc.contributor.authorHOOVER, Marie
dc.contributor.authorHOWARD, Natasha
dc.contributor.authorHUGHES, Melissa
dc.contributor.authorILO, Dicko
dc.contributor.authorIRVINE, Skip
dc.contributor.authorISHOLA, David
dc.contributor.authorJATO, Yvonne
dc.contributor.authorJOE, Madison
dc.contributor.authorJOHNSON, Melvin
dc.contributor.authorKABA, Aboubacar Sidiki
dc.contributor.authorKAGAN, Jonathan
dc.contributor.authorKALLON, Kade
dc.contributor.authorKAMARA, Michael
dc.contributor.authorKANTE, Myriam
dc.contributor.authorKATOUDI, Judith
dc.contributor.authorKEITA, Cheick Mohamed
dc.contributor.authorKEITA, Sakoba
dc.contributor.authorKEITA, Seykou
dc.contributor.authorKENNEDY, Stephen
dc.contributor.authorKESHINRO, Babajide
dc.contributor.authorKIAWU, Hassan
dc.contributor.authorKIEH, Mark
dc.contributor.authorKILLINGER, Brent
dc.contributor.authorKINDA, Moumouni
dc.contributor.authorKIRCHOFF, Matthew
dc.contributor.authorKOCHER, Gregory
dc.contributor.authorKODIO, Mamoudou
dc.contributor.authorKOHN, Brian
dc.contributor.authorKOIVOGUI, Lamine
dc.contributor.authorKOJAN, Richard
dc.contributor.authorKOLIÉ, Cece Francis
dc.contributor.authorKOLIÉ, Jacques Seraphin
dc.contributor.authorKOLLIE, David
dc.contributor.authorKOPKA, Stacy
dc.contributor.authorKOROMA, Bockarie
dc.contributor.authorKOWUOR, Dickens
dc.contributor.authorKPAYIELI-FREEMAN, Catherine
dc.contributor.authorKWAST, Liane
dc.contributor.authorLACABARATZ, Christine
dc.contributor.authorLACARRA, Boris
dc.contributor.authorLAMBERT, Laurie
dc.contributor.authorLAMBETH, Courtney
dc.contributor.authorLANCREY-JAVAL, Solange
dc.contributor.authorLANE, H. Clifford
dc.contributor.authorLANGBA, Shadrach
dc.contributor.authorLAWAL, Bolarinde
dc.contributor.authorLEE, Andrew Wen-Tseng
dc.contributor.authorLEE, Shona
dc.contributor.authorLEES, Shelley
dc.contributor.authorLEFEVRE, Annabelle
dc.contributor.authorLEIGH, Bailah
dc.contributor.authorLEMARCIS, Frederic
dc.contributor.authorLÉVY, Yves
dc.contributor.authorLEVY-MARCHAL, Claire
dc.contributor.authorLEYSSEN, Maarten
dc.contributor.authorLHOMME, Edouard
dc.contributor.authorLIANG, Janie
dc.contributor.authorLINGA, Mameni
dc.contributor.authorLIU, Ken
dc.contributor.authorLOWE, Brett
dc.contributor.authorLYSANDER, Julia
dc.contributor.authorMAHAMADOU, Ibrah
dc.contributor.authorMALJKOVIC-BERRY, Irina
dc.contributor.authorMAMBIAH, Marvington
dc.contributor.authorMANNO, Daniela
dc.contributor.authorMARCHAND, Jonathan
dc.contributor.authorMARRON, Lindsay
dc.contributor.authorMASSAQUOI, Moses
dc.contributor.authorMASSON, Laure
dc.contributor.authorMATARD, Charly
dc.contributor.authorMAZUR, Steven
dc.contributor.authorMCCULLOUGH, John
dc.contributor.authorMCFADYEN, Katherine
dc.contributor.authorMCLEAN, Chelsea
dc.contributor.authorMERCIER, Noémie
dc.contributor.authorMICHAVILA, Pauline
dc.contributor.authorMILLER, Tracey
dc.contributor.authorMILLIMOUNO, Niouma Pascal
dc.contributor.authorMIRANDA, Alejandra
dc.contributor.authorMOHAMED, Soumaya
dc.contributor.authorMOONEY, Tom
dc.contributor.authorMUAMBA, Dally
dc.contributor.authorMULBAH, James
dc.contributor.authorNDAMENYAA, Rita Lukoo
dc.contributor.authorNEATON, James
dc.contributor.authorNEBOUA, Désiré
dc.contributor.authorNELSON, Micki
dc.contributor.authorNEWELL, Kevin
dc.contributor.authorNGUYEN, Vinh-Kim
dc.contributor.authorNJIE, Yusupha
dc.contributor.authorNJOH, Wissedi
dc.contributor.authorNOVOTNEY-BARRY, Anna
dc.contributor.authorONORATO, Matthew
dc.contributor.authorONWUCHEKWA, Uma
dc.contributor.authorORSEGA, Susan
dc.contributor.authorORTEGA-PEREZ, Inmaculada
dc.contributor.authorOSBORNE, Cynthia
dc.contributor.authorOTIENO, Tuda
dc.contributor.authorOULAÏ, Davy
dc.contributor.authorPATEL, Sushma
dc.contributor.authorPEART, Danielle
dc.contributor.authorPEETERS, Martine
dc.contributor.authorPETTITT, James
dc.contributor.authorPEIFFER-SMADJA, Nathan
dc.contributor.authorPHILLIPS, Robert
dc.contributor.authorPIERSON, Jerome
dc.contributor.authorPIOT, Peter
dc.contributor.authorPIZIALI, Micheal
dc.contributor.authorPONG, Stéphany
dc.contributor.authorPOSTNIKOVA, Elena
dc.contributor.authorPROFFITT, Calvin
dc.contributor.authorQUACH, Alexandre
dc.contributor.authorQUIGLEY, Sinead
dc.contributor.authorRANDUNU, Nadeeka
dc.contributor.authorRICHERT, Laura
dc.contributor.authorRIVIÈRE, Priscille
dc.contributor.authorROBINSON, Cynthia
dc.contributor.authorROY, Céline
dc.contributor.authorRUSSELL, Amy Falk
dc.contributor.authorSAHR, Philip
dc.contributor.authorSALIBA, Katy
dc.contributor.authorSAMAI, Mohamed
dc.contributor.authorSAMAKE, Sibiry
dc.contributor.authorSANDRUS, Jen
dc.contributor.authorSANOGO, Ibrahim
dc.contributor.authorSARRO, Yeya Sadio
dc.contributor.authorSAWADOGO, Serge
dc.contributor.authorSAYADI, Sani
dc.contributor.authorSCHVARTZ, Maxime
dc.contributor.authorSCHWIMMER, Christine
dc.contributor.authorSECKA, Fatou
dc.contributor.authorSHARMA, Heema
dc.contributor.authorSHELLEY, Denise
dc.contributor.authorSHOBAYO, Bode
dc.contributor.authorSIDDIQUI, Sophia
dc.contributor.authorSIMON, Jakub
dc.contributor.authorSIMPSON, Shelly
dc.contributor.authorSIVAHERA, Billy Muyisa
dc.contributor.authorSLATER, Karen
dc.contributor.authorSMOLSKIS, Mary
dc.contributor.authorSMOUT, Elizabeth
dc.contributor.authorSNOWDEN, Emily
dc.contributor.authorSOUTTHIPHONG, Anne-Aygline
dc.contributor.authorSOW, Amadou
dc.contributor.authorSOW, Samba
dc.contributor.authorSOW, Ydrissa
dc.contributor.authorSTIRRATT, Michael
dc.contributor.authorSTOOP, Jeroen
dc.contributor.authorSUBRAMANIAM, Guna
dc.contributor.authorSURUGUE, Léa
dc.contributor.authorSWALES, Nathalie
dc.contributor.authorTAMBA, Sienneh
dc.contributor.authorTANG, Chan
dc.contributor.authorTANGARA, Cheick
dc.contributor.authorTAPIA, Milagritos
dc.contributor.authorTEAHTON, Julius
dc.contributor.authorTEGLI, Jemee
dc.contributor.authorTERMOTE, Monique
dc.contributor.authorTHAURIGNAC, Guillaume
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorTHOMPSON, Greg
dc.contributor.authorTIERNEY, John
dc.contributor.authorTINDANBIL, Daniel
dc.contributor.authorTOURÉ, Abdoulaye
dc.contributor.authorTOWALID, Elvis
dc.contributor.authorTRAINA, Stacey
dc.contributor.authorTRAORE, Awa
dc.contributor.authorTYEE, Tijili
dc.contributor.authorVALLÉE, David
dc.contributor.authorVATRINET, Renaud
dc.contributor.authorVINCENT, Corine
dc.contributor.authorVOGEL, Susan
dc.contributor.authorWALLET, Cedrick
dc.contributor.authorWARREN, Travis
dc.contributor.authorWATSON-JONES, Deborah
dc.contributor.authorWEAVER, Wade
dc.contributor.authorWENTWORTH, Deborah
dc.contributor.authorWESSEH, Cecelia
dc.contributor.authorWHITWORTH, Hilary
dc.contributor.authorWHITWORTH, Jimmy
dc.contributor.authorWIEDEMANN, Aurelie
dc.contributor.authorWILLEMS, Wouter
dc.contributor.authorWILSON, Barthalomew
dc.contributor.authorWOLF, Jayanthi
dc.contributor.authorWURIE, Alie
dc.contributor.authorYAMADJAKO, Delphine
dc.contributor.authorYARMIE, Quiawiah
dc.contributor.authorYAZDANPANAH, Yazdan
dc.contributor.authorYU, Shuiqing
dc.contributor.authorZEGGANI, Zara
dc.contributor.authorZHOU, Huanying
dc.date.accessioned2024-10-24T14:23:48Z
dc.date.available2024-10-24T14:23:48Z
dc.date.issued2024-09-03
dc.identifier.issn2041-1723en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202720
dc.description.abstractEnRecent Ebola outbreaks underscore the importance of continuous prevention and disease control efforts. Authorized vaccines include Merck’s Ervebo (rVSV-ZEBOV) and Johnson & Johnson’s two-dose combination (Ad26.ZEBOV/MVA-BN-Filo). Here, in a five-year follow-up of the PREVAC randomized trial (NCT02876328), we report the results of the immunology ancillary study of the trial. The primary endpoint is to evaluate long-term memory T-cell responses induced by three vaccine regimens: Ad26–MVA, rVSV, and rVSV–booster. Polyfunctional EBOV-specific CD4+ T-cell responses increase after Ad26 priming and are further boosted by MVA, whereas minimal responses are observed in the rVSV groups, declining after one year. In-vitro expansion for eight days show sustained EBOV-specific T-cell responses for up to 60 months post-prime vaccination with both Ad26-MVA and rVSV, with no decline. Cytokine production analysis identify shared biomarkers between the Ad26-MVA and rVSV groups. In secondary endpoint, we observed an elevation of pro-inflammatory cytokines at Day 7 in the rVSV group. Finally, we establish a correlation between EBOV-specific T-cell responses and anti-EBOV IgG responses. Our findings can guide booster vaccination recommendations and help identify populations likely to benefit from revaccination.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.title.enLong-term cellular immunity of vaccines for Zaire Ebola Virus Diseases
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-024-51453-zen_US
dc.subject.halSciences de l'Homme et Sociétéen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39227399en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page7666en_US
bordeaux.volume15en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRIAen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDNational Institutes of Healthen_US
bordeaux.identifier.funderIDHorizon 2020en_US
bordeaux.import.sourcehal
hal.identifierhal-04707176
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2024-09-03&rft.volume=15&rft.issue=1&rft.spage=7666&rft.epage=7666&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=WIEDEMANN,%20Aur%C3%A9lie&LHOMME,%20Edouard&HUCHON,%20Melanie&FOUCAT,%20Emile&B%C3%89RERD-CAMARA,%20Marion&rft.genre=article


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