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Transition to dolutegravir-based ART in 35 low- and middle-income countries: a global survey of HIV care clinics

dc.rights.licenseopenen_US
dc.contributor.authorZANIEWSKI, Elizabeth
dc.contributor.authorSKRIVANKOVA, Veronika Whitesell
dc.contributor.authorBRAZIER, Ellen
dc.contributor.authorAVIHINGSANON, Anchalee
dc.contributor.authorCARDOSO, Sandra Wagner
dc.contributor.authorCESAR, Carina
dc.contributor.authorCHENAL, Henri
dc.contributor.authorCRABTREE-RAMIREZ, Brenda E
dc.contributor.authorDITANGCO, Rossana A
dc.contributor.authorEBASONE, Peter Vanes
dc.contributor.authorELEY, Brian
dc.contributor.authorEUVRARD, Jonathan George
dc.contributor.authorFATTI, Geoffrey
dc.contributor.authorHUWA, Jacqueline Madalitso
dc.contributor.authorLELO, Patricia
dc.contributor.authorMACHADO, Daisy Maria
dc.contributor.authorMESSOU, Eugene Kouassi
dc.contributor.authorMINGA, Albert Kla
dc.contributor.authorMULEEBWA, Joseph
dc.contributor.authorMUNDHE, Sanjay
dc.contributor.authorMURENZI, Gad
dc.contributor.authorMUYINDIKE, Winnie R
dc.contributor.authorNSONDE, Dominique Mahambou
dc.contributor.authorOBATSA, Sarah M
dc.contributor.authorODHIAMBO, Joseph
dc.contributor.authorPROZESKY, Hans Walter
dc.contributor.authorRUNGMAITREE, Supattra
dc.contributor.authorSEMEERE, Aggrey Semwendero
dc.contributor.authorSEYDI, Moussa
dc.contributor.authorSIPAMBO, Nosisa
dc.contributor.authorSUDJARITRUK, Tavitiya
dc.contributor.authorTECHNAU, Karl-Gunter
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorTIENDREBEOGO, Thierry
dc.contributor.authorTWIZERE, Christelle
dc.contributor.authorBALLIF, Marie
dc.date.accessioned2024-10-18T08:54:50Z
dc.date.available2024-10-18T08:54:50Z
dc.date.issued2024-09-05
dc.identifier.issn1473-5571en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202577
dc.description.abstractEnOBJECTIVE: We studied the transition to dolutegravir-containing antiretroviral therapy (ART) at HIV treatment clinics within the International epidemiology Databases to Evaluate AIDS (IeDEA). DESIGN: Site-level survey conducted in 2020-2021 among HIV clinics in low- and middle-income countries (LMICs). METHODS: We assessed the status of dolutegravir rollout and viral load and drug resistance testing practices for patients on ART switching to dolutegravir-based regimens. We used generalized estimating equations to assess associations between clinic rollout of both first- and second-line dolutegravir-based ART regimens (dual rollout) and site-level factors. RESULTS: Of 179 surveyed clinics, 175 (98%) participated; 137 (78%) from Africa, 30 (17%) from the Asia-Pacific, and 8 (5%) from Latin America. Most clinics (80%) were in low- or lower-middle-income countries, and there were a mix of primary-, secondary- and tertiary-level clinics. Ninety percent reported rollout of first-line dolutegravir, 59% of second-line, 94% of first- or second-line and 55% of dual rollout. The adjusted odds of dual rollout were higher among tertiary-level (aOR 4.00; 95% CI 1.39 to 11.47) and secondary-level clinics (aOR 3.66; 95% CI 2.19 to 6.11) than in primary-level clinics. Over half (59%) of clinics that introduced first- or second-line dolutegravir-based ART required recent viral load testing before switching to dolutegravir, and 15% performed genotypic resistance testing at switch. CONCLUSIONS: Dolutegravir-based ART was rolled out at nearly all IeDEA clinics in LMICs, yet many switched patients to dolutegravir without recent viral load testing and drug resistance testing was rarely performed. Without such testing, drug resistance among patient switching to dolutegravir may go undetected.
dc.language.isoENen_US
dc.title.enTransition to dolutegravir-based ART in 35 low- and middle-income countries: a global survey of HIV care clinics
dc.title.alternativeAIDSen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qad.0000000000004007en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39236112en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
hal.identifierhal-04743116
hal.version1
hal.date.transferred2024-10-18T08:54:55Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=AIDS.%20Official%20journal%20of%20the%20international%20AIDS%20Society&rft.date=2024-09-05&rft.eissn=1473-5571&rft.issn=1473-5571&rft.au=ZANIEWSKI,%20Elizabeth&SKRIVANKOVA,%20Veronika%20Whitesell&BRAZIER,%20Ellen&AVIHINGSANON,%20Anchalee&CARDOSO,%20Sandra%20Wagner&rft.genre=article


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