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Association of cardiovascular disease risk with liver steatosis and fibrosis in people living with hiv in low- and middle-income countries

dc.rights.licenseopenen_US
dc.contributor.authorKUNIHOLM, Mark H
dc.contributor.authorMURENZI, Gad
dc.contributor.authorSHUMBUSHO, Fabienne
dc.contributor.authorBRAZIER, Ellen
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorPLAISY, Marie Kerbie
dc.contributor.authorMENSAH, Ephrem
dc.contributor.authorWANDELER, Gilles
dc.contributor.authorRIEBENSAHM, Carlotta
dc.contributor.authorCHIHOTA, Belinda V
dc.contributor.authorSAMALA, Niharika
dc.contributor.authorDIERO, Lameck
dc.contributor.authorSEMEERE, Aggrey S
dc.contributor.authorCHANYACHUKUL, Thida
dc.contributor.authorBORSE, Rohidas
dc.contributor.authorNGUYEN, Dung T H
dc.contributor.authorPERAZZO, Hugo
dc.contributor.authorLOPEZ-INIGUEZ, Alvaro
dc.contributor.authorCASTILHO, Jessica L
dc.contributor.authorMARURI, Fernanda
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorJAQUET, Antoine
dc.date.accessioned2024-10-18T08:49:00Z
dc.date.available2024-10-18T08:49:00Z
dc.date.issued2024-09-12
dc.identifier.issn1473-5571en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202576
dc.description.abstractEnOBJECTIVE: To understand the relationship between cardiovascular disease (CVD) risk and liver steatosis and fibrosis among people living with HIV (PLWH) ≥40 years on antiretroviral therapy (ART) in low- and middle-income countries (LMIC). DESIGN: We used cross-sectional behavioral and clinical data collected during study enrollment visits in 2020-2022 for the Sentinel Research Network of International epidemiology Databases to Evaluate AIDS (SRN of IeDEA). METHODS: Ten-year CVD risk was calculated using 2019 World Health Organization non-laboratory and laboratory models. Transient elastography (TE) was used to assess liver disease. Presence of steatosis and significant fibrosis were defined by Controlled Attenuation Parameter (CAP) ≥248 dB/m and liver stiffness measurement (LSM) ≥7.1 kPa, respectively. Participants with viral hepatitis, hazardous alcohol consumption and unsuppressed HIV viral load were excluded from the analysis. Logistic regression was used to estimate odds ratios, adjusting for study site, CD4 T cell count, stavudine and didanosine exposure, and in models stratified by sex and geographic region. RESULTS: There were 1,750 participants from nine LMIC. Median CVD risk was 3% for both non-laboratory and laboratory-based models. Adjusted odds ratios (ORs) for steatosis and significant fibrosis associated with laboratory CVD risk (≥10% vs. <5%) were OR = 1.83 (95% confidence interval:(CI) = 1.21-2.76; P = 0.004) and OR = 1.62 (95% CI = 0.85-3.07; P = 0.14), respectively. Associations of CVD risk with steatosis were stronger in males and among participants at study sites outside Africa. CONCLUSIONS: Higher CVD risk was associated with steatosis but not with significant fibrosis in PLWH in our LMIC cohort.
dc.language.isoENen_US
dc.title.enAssociation of cardiovascular disease risk with liver steatosis and fibrosis in people living with hiv in low- and middle-income countries
dc.title.alternativeAidsen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qad.0000000000004012en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39264586en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
hal.identifierhal-04743093
hal.version1
hal.date.transferred2024-10-18T08:49:03Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=AIDS.%20Official%20journal%20of%20the%20international%20AIDS%20Society&amp;rft.date=2024-09-12&amp;rft.eissn=1473-5571&amp;rft.issn=1473-5571&amp;rft.au=KUNIHOLM,%20Mark%20H&amp;MURENZI,%20Gad&amp;SHUMBUSHO,%20Fabienne&amp;BRAZIER,%20Ellen&amp;PLAISY,%20Marie%20Kerbie&amp;rft.genre=article


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