Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study
| dc.rights.license | open | en_US |
| dc.contributor.author | LENGELE, Laetitia | |
| dc.contributor.author | ROLLAND, Yves | |
| dc.contributor.author | MARTINEZ, Laurent | |
| dc.contributor.author | GUYONNET, Sophie | |
| dc.contributor.author | PARINI, Angelo | |
| dc.contributor.author | LUCAS, Alexandre | |
| dc.contributor.author | VELLAS, Bruno | |
| dc.contributor.author | BARRETO, Philipe De Souto | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529 IDREF: 058586105 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELVA, Fleur | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SAMIER FOUBERT, Alexandra | |
| dc.date.accessioned | 2024-10-14T10:16:21Z | |
| dc.date.available | 2024-10-14T10:16:21Z | |
| dc.date.issued | 2024-01-01 | |
| dc.identifier.issn | 1758-535X | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/202477 | |
| dc.description.abstractEn | Abstract Background Weight and appetite regulation have been associated with the expression and secretion of ATPase inhibitory factor 1 (IF1) and growth differentiation factor-15 (GDF-15), 2 potential biomarkers for age-related mitochondrial dysfunction. The aim was to explore the associations between these biomarkers and nutritional variables in the Multidomain Alzheimer Preventive Trial study. Methods IF1 and GDF-15 plasma levels were quantified at 1-year follow-up. The nutritional status was measured using the Mini Nutritional Assessment (MNA) score variation between baseline and 1- and 2-year visits; appetite loss was extracted from the MNA. Bodyweight was measured every 6 months until the third year and then yearly until the fifth year of follow-up, and weight loss was established if the loss was greater than 5% or 10% within the past 6 or 12 months, respectively. Bidirectional associations of IF1 and GDF-15 levels with malnutrition, appetite, and weight loss were examined. The interactions between individual IF1 and GDF-15 with sex were explored. Results Four hundred and forty-eight participants had MNA data and 1 045 had weight loss data. All the associations between IF1 levels and the MNA score, appetite loss, and weight loss were nonsignificant. Higher GDF-15 levels were cross-sectionally associated with appetite loss at the first year of follow-up, and the GDF-15 highest quartile was associated with nearly 80% higher risks of weight loss over 4 years. Interactions between IF1 and GDF-15 levels, and between these 2 markers and sex were not significantly associated with the outcomes. Conclusions GDF-15 plasma levels were related to key malnutrition criteria. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Biomarkers | |
| dc.subject.en | Nutrition | |
| dc.subject.en | Successful aging | |
| dc.title.en | Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study | |
| dc.title.alternative | J Gerontol A Biol Sci Med Sci | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/gerona/glad236 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 37804244 | en_US |
| bordeaux.journal | Journals of Gerontology Series A: Biological Sciences and Medical Sciences | en_US |
| bordeaux.volume | 79 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | ACTIVE_BPH | en_US |
| bordeaux.team | EPICENE_BPH | en_US |
| bordeaux.team | PHARES_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut de Recherche Pierre Fabre | en_US |
| hal.identifier | hal-04485939 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journals%20of%20Gerontology%20Series%20A:%20Biological%20Sciences%20and%20Medical%20Sciences&rft.date=2024-01-01&rft.volume=79&rft.issue=1&rft.eissn=1758-535X&rft.issn=1758-535X&rft.au=LENGELE,%20Laetitia&ROLLAND,%20Yves&MARTINEZ,%20Laurent&GUYONNET,%20Sophie&PARINI,%20Angelo&rft.genre=article |
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||