Two missense mutations, E123Q and K151E, identified in the ERG11 allele of an azole-resistant isolate of Candida kefyr recovered from a stem cell transplant patient for acute myeloid leukemia.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | COUZIGOU, Célia | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | GABRIEL, Frédéric | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | BITEAU, Nicolas | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | FITTON-OUHABI, Valérie | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | NOËL, Thierry | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | ACCOCEBERRY, Isabelle
IDREF: 075520818 | |
| dc.date.accessioned | 2024-10-07T10:55:41Z | |
| dc.date.available | 2024-10-07T10:55:41Z | |
| dc.date.issued | 2014-07-01 | |
| dc.identifier.issn | 2211-7539 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/202288 | |
| dc.description.abstractEn | We report on the first cloning and nucleotide sequencing of an ERG11 allele from a clinical isolate of Candida kefyr cross-resistant to azole antifungals. It was recovered from a stem cell transplant patient, in an oncohematology unit exhibiting unexpected high prevalence of C. kefyr. Two amino acid substitutions were identified: K151E, whose role in fluconazole resistance was already demonstrated in Candida albicans, and E123Q, a new substitution never described so far in azole-resistant Candida yeast. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Azole resistance; Candida kefyr; ERG11; Kluyveromyces marxianus; Single nucleotide polymorphism. | |
| dc.title.en | Two missense mutations, E123Q and K151E, identified in the ERG11 allele of an azole-resistant isolate of Candida kefyr recovered from a stem cell transplant patient for acute myeloid leukemia. | |
| dc.title.alternative | Med Mycol Case Rep | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.mmcr.2014.04.002 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie | en_US |
| dc.identifier.pubmed | 24936404 | en_US |
| bordeaux.journal | Medical Mycology Case Reports | en_US |
| bordeaux.page | 12-5 | en_US |
| bordeaux.volume | 5 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Medical%20Mycology%20Case%20Reports&rft.date=2014-07-01&rft.volume=5&rft.spage=12-5&rft.epage=12-5&rft.eissn=2211-7539&rft.issn=2211-7539&rft.au=COUZIGOU,%20C%C3%A9lia&GABRIEL,%20Fr%C3%A9d%C3%A9ric&BITEAU,%20Nicolas&FITTON-OUHABI,%20Val%C3%A9rie&NO%C3%8BL,%20Thierry&rft.genre=article |
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