Effects of Head-Only Exposure to 900 MHz GSM Electromagnetic Fields in Rats: Changes in Neuronal Activity as Revealed by c-Fos Imaging without Concomitant Cognitive Impairments
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | BONTEMPI, Bruno
IDREF: 119124459 | |
| dc.contributor.author | LEVEQUE, Philippe | |
| dc.contributor.author | DUBREUIL, Diane | |
| dc.contributor.author | JAY, Therese M | |
| dc.contributor.author | EDELINE, Jean-Marc | |
| dc.date.accessioned | 2024-09-30T10:02:53Z | |
| dc.date.available | 2024-09-30T10:02:53Z | |
| dc.date.issued | 2024-08-27 | |
| dc.identifier.issn | 2227-9059 | en_US |
| dc.identifier.other | https: //www.mdpi.com/article/10.3390/biomedicines12091954/s1 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/202027 | |
| dc.description.abstractEn | Over the last two decades, animal models have been used to evaluate the physiological and cognitive effects of mobile phone exposure. Here, we used a head-only exposure system in rats to determine whether exposure to 900 MHz GSM electromagnetic fields (EMFs) induces regional changes in neuronal activation as revealed by c-Fos imaging. In a first study, rats were exposed for 2 h to brain average specific absorption rates (BASARs) ranging from 0.5 to 6 W/kg. Changes in neuronal activation were found to be dose-dependent, with significant increases in c-Fos expression occurring at BASAR of 1 W/kg in prelimbic, infralimbic, frontal, and cingulate cortices. In a second study, rats were submitted to either a spatial working memory (WM) task in a radial maze or a spatial reference memory (RM) task in an open field arena. Exposures (45 min) were conducted before each daily training session (BASARs of 1 and 3.5 W/kg). Control groups included sham-exposed and control cage animals. In both tasks, behavioral performance evolved similarly in the four groups over testing days. However, c-Fos staining was significantly reduced in cortical areas (prelimbic, infralimbic, frontal, cingulate, and visual cortices) and in the hippocampus of animals engaged in the WM task (BASARs of 1 and 3.5 W/kg). In the RM task, EMF exposure-induced decreases were limited to temporal and visual cortices (BASAR of 1 W/kg). These results demonstrate that both acute and subchronic exposures to 900 MHz EMFs can produce region-specific changes in brain activity patterns, which are, however, insufficient to induce detectable cognitive deficits in the behavioral paradigms used here. | |
| dc.description.sponsorship | Effets d'exposition aux radiofréquences chez des souris âgées ou modélisant la maladie d'Alzheimer : approches combinées comportementale et neurovasculaire - ANR-10-CESA-0002 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | spatial learning | |
| dc.subject.en | immunohistochemistry | |
| dc.subject.en | rat | |
| dc.subject.en | radio frequency | |
| dc.title.en | Effects of Head-Only Exposure to 900 MHz GSM Electromagnetic Fields in Rats: Changes in Neuronal Activity as Revealed by c-Fos Imaging without Concomitant Cognitive Impairments | |
| dc.title.alternative | Biomedicines | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/biomedicines12091954 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 39335468 | en_US |
| bordeaux.journal | Biomedicines | en_US |
| bordeaux.volume | 12 | en_US |
| bordeaux.hal.laboratories | Institut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287 | en_US |
| bordeaux.issue | 9 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04679880 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | CC BY | en_US |
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