Afficher la notice abrégée

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease.

dc.rights.licenseopenen_US
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorCARO, Ilana
dc.contributor.authorWESTERN, Daniel
dc.contributor.authorNAMBA, Shinichi
dc.contributor.authorSUN, Na
dc.contributor.authorKAWAGUCHI, Shuji
dc.contributor.authorHE, Yunye
dc.contributor.authorFUJITA, Masashi
dc.contributor.authorROSHCHUPKIN, Gennady
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorD'AOUST, Tim
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUPERRON, Marie-Gabrielle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSARGURUPREMRAJ, Murali
dc.contributor.authorTSUCHIDA, Ami
dc.contributor.authorKOIDO, Masaru
dc.contributor.authorAHMADI, Marziehsadat
dc.contributor.authorYANG, Chengran
dc.contributor.authorTIMSINA, Jigyasha
dc.contributor.authorIBANEZ, Laura
dc.contributor.authorMATSUDA, Koichi
dc.contributor.authorSUZUKI, Yutaka
dc.contributor.authorODA, Yoshiya
dc.contributor.authorKANAI, Akinori
dc.contributor.authorAULD, Dan
dc.contributor.authorJANDAGHI, Pouria
dc.contributor.authorMUNTER, Hans Markus
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorASTAFEVA, Iana
dc.contributor.authorPUERTA, Raquel
dc.contributor.authorROTTER, Jerome
dc.contributor.authorJOLIOT, Marc
dc.contributor.authorPSATY, Bruce
dc.contributor.authorBIS, Joshua
dc.contributor.authorLONGSTRETH, Will
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorCOUFFINHAL, Thierry
dc.contributor.authorGARCIA-GONZALEZ, Pablo
dc.contributor.authorPYTEL, Vanesa
dc.contributor.authorCANO, Amanda
dc.contributor.authorBOADA, Mercè
dc.contributor.authorLATHROP, Mark
dc.contributor.authorLE GRAND, Quentin
dc.contributor.authorLAUNER, Lenore
dc.contributor.authorWARDLAW, Joanna
dc.contributor.authorHEIMAN, Myriam
dc.contributor.authorRUIZ, Agustin
dc.contributor.authorMATTHEWS, Paul
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorFORNAGE, Myriam
dc.contributor.authorADAMS, Hieab
dc.contributor.authorMISHRA, Aniket
dc.contributor.authorTRÉGOUËT, David-Alexandre
dc.contributor.authorOKADA, Yukinori
dc.contributor.authorKELLIS, Manolis
dc.contributor.authorDE JAGER, Philip
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorKAMATANI, Yoichiro
dc.contributor.authorMATSUDA, Fumihiko
dc.contributor.authorCRUCHAGA, Carlos
dc.date.accessioned2024-09-30T08:03:09Z
dc.date.available2024-09-30T08:03:09Z
dc.date.issued2024-07-02
dc.identifier.issn2693-5015en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202006
dc.description.abstractEnCerebral small vessel disease (cSVD) is a leading cause of stroke and dementia with no specific mechanism-based treatment. We used Mendelian randomization to combine a unique cerebrospinal fluid (CSF) and plasma pQTL resource with the latest European-ancestry GWAS of MRI-markers of cSVD (white matter hyperintensities, perivascular spaces). We describe a new biological fingerprint of 49 protein-cSVD associations, predominantly in the CSF. We implemented a multipronged follow-up, across fluids, platforms, and ancestries (Europeans and East-Asian), including testing associations of direct plasma protein measurements with MRI-cSVD. We highlight 16 proteins robustly associated in both CSF and plasma, with 24/4 proteins identified in CSF/plasma only. cSVD-proteins were enriched in extracellular matrix and immune response pathways, and in genes enriched in microglia and specific microglial states (integration with single-nucleus RNA sequencing). Immune-related proteins were associated with MRI-cSVD already at age twenty. Half of cSVD-proteins were associated with stroke, dementia, or both, and seven cSVD-proteins are targets for known drugs (used for other indications in directions compatible with beneficial therapeutic effects. This first cSVD proteogenomic signature opens new avenues for biomarker and therapeutic developments.
dc.language.isoENen_US
dc.title.enProteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease.
dc.title.alternativeRes Sqen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.21203/rs.3.rs-4535534/v1en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed39011113en_US
bordeaux.journalResearch Square - Preprinten_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04713951
hal.version1
hal.date.transferred2024-09-30T08:03:15Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Research%20Square%20-%20Preprint&rft.date=2024-07-02&rft.eissn=2693-5015&rft.issn=2693-5015&rft.au=DEBETTE,%20Stephanie&CARO,%20Ilana&WESTERN,%20Daniel&NAMBA,%20Shinichi&SUN,%20Na&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée