Multivalent effect of glycopolypeptide based nanoparticles for galectin binding
dc.rights.license | open | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Laboratoire de chimie de coordination [LCC] | |
dc.contributor.author | BONDUELLE, Colin
IDREF: 134527046 | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | INSERM, U1026, Tissue Bioengn, Univ Bordeaux | |
dc.contributor.author | DE OLIVEIRA, Hugo | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | GAUCHE, Cony | |
hal.structure.identifier | Dublin City Univ, Sci Chem Sci | |
dc.contributor.author | HUANG, Jin | |
hal.structure.identifier | Dublin City Univ, Sci Chem Sci | |
hal.structure.identifier | Pol Chem & Biomat Lab, Dept Pharmaceut & Med Chem, Dublin | |
dc.contributor.author | HEISE, Andreas | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1359-7345 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20198 | |
dc.description.abstractEn | Synthetic glycopolypeptides are versatile glycopolymers used to conceive bioinspired nanoassemblies. In this work, novel amphiphilic glycopolypeptides were designed to incorporate lactose or galactan in order to prepare polymeric nanoassemblies with sizes below 50 nm. The bioactivity of the two different outer surface sugar units was evaluated by defining glycan relative binding affinities to human galectins 1 and 3. A specific multivalent effect was found only for polymeric nanoparticles displaying galactan with a significant increase of the binding activity as compared to free glycan in solution. Such synthetic designs present great potential as therapeutic tools to address galectin related pathologies. | |
dc.language.iso | en | |
dc.publisher | Royal Society of Chemistry | |
dc.title.en | Multivalent effect of glycopolypeptide based nanoparticles for galectin binding | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1039/c6cc06437j | |
dc.subject.hal | Chimie/Polymères | |
bordeaux.journal | Chemical Communications | |
bordeaux.page | 11251-11254 | |
bordeaux.volume | 52 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.issue | 75 | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01372522 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01372522v1 | |
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