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Cord serum cytokines at birth and children's trajectories of mood dysregulation symptoms from 3 to 8 years: The EDEN birth cohort

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHERBEIN, Marie
dc.contributor.authorBARBOSA, Susana
dc.contributor.authorCOLLET, Ophélie
dc.contributor.authorKHALFALLAH, Olfa
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorNAVARRO, Marie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBAILHACHE, Marion
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorIV, Nicolas
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
IDREF: 069471851
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSUTTER-DALLAY, Anne-Laure
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorKOEHL, Muriel
dc.contributor.authorCAPURON, Lucile
IDREF: 167018736
dc.contributor.authorELLUL, Pierre
dc.contributor.authorPEYRE, Hugo
dc.contributor.authorVAN DER WAERDEN, Judith
dc.contributor.authorMELCHIOR, Maria
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOTE, Sylvana
dc.contributor.authorHEUDE, Barbara
dc.contributor.authorGLAICHENHAUS, Nicolas
dc.contributor.authorDAVIDOVIC, Laetitia
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGALERA, Cedric
ORCID: 0000-0003-0549-9608
IDREF: 110034007
dc.date.accessioned2024-09-24T13:49:37Z
dc.date.available2024-09-24T13:49:37Z
dc.date.issued2024-07-01
dc.identifier.issn2666-3546en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201770
dc.description.abstractEnThere is growing evidence that in utero imbalance immune activity plays a role in the development of neurodevelopmental and psychiatric disorders in children. Mood dysregulation (MD) is a debilitating transnosographic syndrome whose underlying pathophysiological mechanisms could be revealed by studying its biomarkers using the Research Domain Criteria (RDoC) model. Our aim was to study the association between the network of cord serum cytokines, and mood dysregulation trajectories in offsprings between 3 and 8 years of age. We used the data of a study nested in the French birth cohort EDEN that took place from 2003 to 2014 and followed mother-child dyads from the second trimester of pregnancy until the children were 8 years of age. The 2002 mother-child dyads were recruited from the general population through their pregnancy follow-up in two French university hospitals. 871 of them were included in the nested cohort and cord serum cytokine levels were measured at birth. Children's mood dysregulation symptoms were assessed with the Strengths and Difficulties Questionnaire Dysregulation Profile at the ages 3, 5 and 8 years in order to model their mood dysregulation trajectories. Out of the 871 participating dyads, 53% of the children were male. 2.1% of the children presented a high mood dysregulation trajectory whereas the others were considered as physiological variations. We found a significant negative association between TNF-α cord serum levels and a high mood dysregulation trajectory when considering confounding factors such as maternal depression during pregnancy (adjusted Odds Ratio (aOR) = 0.35, 95% Confidence Interval (CI) [0.18-0.67]). Immune imbalance at birth could play a role in the onset of mood dysregulation symptoms. Our findings throw new light on putative immune mechanisms implicated in the development of mood dysregulation and should lead to future animal and epidemiological studies.
dc.description.sponsorshipDéterminants sociaux des troubles psychologiques et des apprentissages chez les enfants d'âge scolaireen_US
dc.description.sponsorshipFacteurs de Risque Biologiques et Psychosociaux Précoces Influençant le Risque Longitudinal sur la Santé Mentale des Enfantsen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enBirth cohort
dc.subject.enChild and adolescent psychiatry
dc.subject.enCytokines
dc.subject.enDMDD
dc.subject.enEpidemiology
dc.subject.enImmune system
dc.subject.enIrritability
dc.subject.enPregnancy
dc.subject.enTNFα
dc.title.enCord serum cytokines at birth and children's trajectories of mood dysregulation symptoms from 3 to 8 years: The EDEN birth cohort
dc.title.alternativeBrain Behav Immun Healthen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.bbih.2024.100768en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38586283en_US
bordeaux.journalBrain, Behavior & Immunity - Healthen_US
bordeaux.page100768en_US
bordeaux.volume38en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionBordeaux INP
bordeaux.institutionINRAE
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDNestléen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.import.sourcehal
hal.identifierhal-04705535
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Brain,%20Behavior%20&%20Immunity%20-%20Health&rft.date=2024-07-01&rft.volume=38&rft.spage=100768&rft.epage=100768&rft.eissn=2666-3546&rft.issn=2666-3546&rft.au=HERBEIN,%20Marie&BARBOSA,%20Susana&COLLET,%20Oph%C3%A9lie&KHALFALLAH,%20Olfa&NAVARRO,%20Marie&rft.genre=article


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