Biomonitoring of fluoroalkylated substances in Antarctica seabird plasma: Development and validation of a fast and rugged method using on-line concentration liquid chromatography tandem mass spectrometry
| dc.rights.license | open | en_US |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | MUNOZ, Gabriel | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | LABADIE, Pierre | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | GENESTE, Emmanuel | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | PARDON, Patrick | |
| hal.structure.identifier | Centre d'Études Biologiques de Chizé - UMR 7372 [CEBC] | |
| dc.contributor.author | TARTU, Sabrina | |
| hal.structure.identifier | Centre d'Études Biologiques de Chizé - UMR 7372 [CEBC] | |
| dc.contributor.author | CHASTEL, Olivier | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | BUDZINSKI, Hélène
ORCID: 0000-0003-1028-9154 IDREF: 070478090 | |
| dc.date.accessioned | 2024-09-23T08:20:52Z | |
| dc.date.available | 2024-09-23T08:20:52Z | |
| dc.date.issued | 2017-07-07 | |
| dc.identifier.issn | 0021-9673 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/201725 | |
| dc.description.abstractEn | We report on a fast, accurate and rugged analytical procedure to determine a wide span of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in seabird plasma. The 26 investigated compounds included perfluoroalkyl carboxylates (C5–C14 PFCAs), perfluoroalkyl sulfonates (C4, C6, C7, C8, C10 PFSAs), perfluorooctane sulfonamide (FOSA) and N-alkyl derivatives (MeFOSA, EtFOSA), N-alkyl perfluorooctane sulfonamido acetic acids (MeFOSAA, EtFOSAA), fluorotelomer sulfonates (4:2 FTSA, 6:2 FTSA, 8:2 FTSA), polyfluoroalkyl phosphate diesters (diPAPs) and perfluorooctane sulfonamide phosphate diester (diSAmPAP). The method described herein requires a reduced sample amount (25 μL) and involves rapid and simple sample preparation (protein precipitation with acetonitrile but without acidification) prior to analysis by on-line solid phase extraction (Oasis HLB sorbent) coupled to high performance liquid chromatography negative electrospray ionization tandem mass spectrometry. The optimization was conducted using experimental designs to account for potential interactions between variables. Out of the 26 target analytes, 23 compounds showed excellent accuracy (± 25% of the expected values). Intermediate precision and matrix effects remained acceptable for most analytes thanks to efficient internal standardization. A human serum standard reference material (NIST SRM 1957) was included in the validation scheme to evaluate method trueness, which proved satisfactory (│Z-scores│54% of ΣPFASs on average). The reduced plasma amount required implies that the present method could also be applied to the analysis of PFASs in the plasma of smaller biological models | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Polyfluoroalkyl substances | |
| dc.subject.en | Antarctica | |
| dc.subject.en | Biomonitoring | |
| dc.subject.en | Seabird | |
| dc.subject.en | Plasma | |
| dc.subject.en | On-line solid phase extraction | |
| dc.subject.en | Method validationa | |
| dc.title.en | Biomonitoring of fluoroalkylated substances in Antarctica seabird plasma: Development and validation of a fast and rugged method using on-line concentration liquid chromatography tandem mass spectrometry | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.chroma.2017.07.024 | en_US |
| dc.subject.hal | Sciences de l'environnement | en_US |
| bordeaux.journal | Journal of Chromatography A | en_US |
| bordeaux.page | 107-117 | en_US |
| bordeaux.volume | 1513 | en_US |
| bordeaux.hal.laboratories | EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | LPTC | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-01572414 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Chromatography%20A&rft.date=2017-07-07&rft.volume=1513&rft.spage=107-117&rft.epage=107-117&rft.eissn=0021-9673&rft.issn=0021-9673&rft.au=MUNOZ,%20Gabriel&LABADIE,%20Pierre&GENESTE,%20Emmanuel&PARDON,%20Patrick&TARTU,%20Sabrina&rft.genre=article |
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