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Clonal succession after prolonged antiretroviral therapy rejuvenates CD8 T cell responses against HIV-1

dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorWHITE, Eoghann
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorPAPAGNO, Laura
dc.contributor.authorSAMRI, Assia
dc.contributor.authorSUGATA, Kenji
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHEJBLUM, Boris
ORCID: 0000-0003-0646-452X
IDREF: 189970316
dc.contributor.authorHENRY, Amy R
dc.contributor.authorROGAN, Daniel C
dc.contributor.authorDARKO, Samuel
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorRECORDON-PINSON, Patricia
dc.contributor.authorDUDOIT, Yasmine
dc.contributor.authorLLEWELLYN-LACEY, Sian
dc.contributor.authorCHAKRABARTI, Lisa A
dc.contributor.authorBUSEYNE, Florence
dc.contributor.authorMIGUELES, Stephen A
dc.contributor.authorPRICE, David A
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorANDREOLA, Marie-Aline
dc.contributor.authorSATOU, Yorifumi
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorKATLAMA, Christine
dc.contributor.authorAUTRAN, Brigitte
dc.contributor.authorDOUEK, Daniel C
dc.contributor.authorAPPAY, Victor
dc.date.accessioned2024-09-20T09:24:11Z
dc.date.available2024-09-20T09:24:11Z
dc.date.issued2024-09-01
dc.identifier.issn1529-2916en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201705
dc.description.abstractEnHuman immunodeficiency virus 1 (HIV-1) infection is characterized by a dynamic and persistent state of viral replication that overwhelms the host immune system in the absence of antiretroviral therapy (ART). The impact of prolonged treatment on the antiviral efficacy of HIV-1-specific CD8 T cells has nonetheless remained unknown. Here, we used single-cell technologies to address this issue in a cohort of aging individuals infected early during the pandemic and subsequently treated with continuous ART. Our data showed that long-term ART was associated with a process of clonal succession, which effectively rejuvenated HIV-1-specific CD8 T cell populations in the face of immune senescence. Tracking individual transcriptomes further revealed that initially dominant CD8 T cell clonotypes displayed signatures of exhaustion and terminal differentiation, whereas newly dominant CD8 T cell clonotypes displayed signatures of early differentiation and stemness associated with natural control of viral replication. These findings reveal a degree of immune resilience that could inform adjunctive treatments for HIV-1.
dc.language.isoENen_US
dc.subject.enCD8-Positive T-Lymphocytes
dc.subject.enHIV-1
dc.subject.enHumans
dc.subject.enHIV Infections
dc.subject.enVirus Replication
dc.subject.enMale
dc.subject.enMiddle Aged
dc.subject.enFemale
dc.subject.enAntiretroviral Therapy
dc.subject.enHighly Active
dc.subject.enAnti-Retroviral Agents
dc.subject.enSingle-Cell Analysis
dc.subject.enCell Differentiation
dc.title.enClonal succession after prolonged antiretroviral therapy rejuvenates CD8 T cell responses against HIV-1
dc.title.alternativeNat Immunolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41590-024-01931-9en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39179934en_US
bordeaux.journalNature Immunologyen_US
bordeaux.page1555-1564en_US
bordeaux.volume25en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRIAen_US
bordeaux.institutionCNRS
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04703528
hal.version1
hal.date.transferred2024-09-20T09:24:15Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Immunology&rft.date=2024-09-01&rft.volume=25&rft.issue=9&rft.spage=1555-1564&rft.epage=1555-1564&rft.eissn=1529-2916&rft.issn=1529-2916&rft.au=WHITE,%20Eoghann&PAPAGNO,%20Laura&SAMRI,%20Assia&SUGATA,%20Kenji&HEJBLUM,%20Boris&rft.genre=article


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