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Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2
| dc.rights.license | open | en_US |
| dc.contributor.author | PROIETTO, D. | |
| dc.contributor.author | DALLAN, B. | |
| dc.contributor.author | GALLERANI, E. | |
| dc.contributor.author | ALBANESE, V. | |
| dc.contributor.author | LLEWELLYN-LACEY, S. | |
| dc.contributor.author | PRICE, D.A. | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | APPAY, Victor | |
| dc.contributor.author | PACIFICO, S. | |
| dc.contributor.author | CAPUTO, A. | |
| dc.contributor.author | NICOLI, F. | |
| dc.contributor.author | GAVIOLI, R. | |
| dc.date.accessioned | 2024-09-19T14:37:41Z | |
| dc.date.available | 2024-09-19T14:37:41Z | |
| dc.date.issued | 2023-01 | |
| dc.identifier.issn | 2076-393X | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/201698 | |
| dc.description.abstractEn | Age-related changes in the immune system are thought to underlie the vulnerability of elderly individuals to emerging viral diseases, such as coronavirus disease 2019 (COVID-19). In this study, we used a fully validated in vitro approach to determine how age impacts the generation of de novo CD8+ T cell responses against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19. Our data revealed a generalized deficit in the ability of elderly individuals to prime the differentiation of naïve precursors into effector CD8+ T cells defined by the expression of interferon (IFN)-γ and the transcription factor T-bet. As a consequence, there was an age-related decline in the diversity of newly generated CD8+ T cell responses targeting a range of typically immunodominant epitopes derived from SARS-CoV-2, accompanied by an overall reduction in the expression frequency of IFN-γ. These findings have potential implications for the development of new strategies to protect the elderly against COVID-19. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | CD8+ T cells | |
| dc.subject.en | immunosenescence | |
| dc.subject.en | SARS-CoV-2 | |
| dc.title.en | Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2 | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/vaccines11010154 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 36679999 | en_US |
| bordeaux.journal | Vaccines | en_US |
| bordeaux.volume | 11 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04702955 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-09-19T14:37:44Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Vaccines&rft.date=2023-01&rft.volume=11&rft.issue=1&rft.eissn=2076-393X&rft.issn=2076-393X&rft.au=PROIETTO,%20D.&DALLAN,%20B.&GALLERANI,%20E.&ALBANESE,%20V.&LLEWELLYN-LACEY,%20S.&rft.genre=article |
