PROIETTO, D.; DALLAN, B.; GALLERANI, E.; ALBANESE, V.; LLEWELLYN-LACEY, S.; PRICE, D.A.; APPAY, Victor; PACIFICO, S.; CAPUTO, A.; NICOLI, F.; GAVIOLI, R.

doi:10.3390/vaccines11010154

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Vaccines. 2023-01, vol. 11, n° 1

Résumé en anglais

Age-related changes in the immune system are thought to underlie the vulnerability of elderly individuals to emerging viral diseases, such as coronavirus disease 2019 (COVID-19). In this study, we used a fully validated in vitro approach to determine how age impacts the generation of de novo CD8+ T cell responses against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19. Our data revealed a generalized deficit in the ability of elderly individuals to prime the differentiation of naïve precursors into effector CD8+ T cells defined by the expression of interferon (IFN)-γ and the transcription factor T-bet. As a consequence, there was an age-related decline in the diversity of newly generated CD8+ T cell responses targeting a range of typically immunodominant epitopes derived from SARS-CoV-2, accompanied by an overall reduction in the expression frequency of IFN-γ. These findings have potential implications for the development of new strategies to protect the elderly against COVID-19.< Réduire

Mots clés en anglais

CD8+ T cells

immunosenescence

SARS-CoV-2

URI

https://oskar-bordeaux.fr/handle/20.500.12278/201698

DOI

http://dx.doi.org/10.3390/vaccines11010154

Unités de recherche

ImmunoConcEpT - UMR 5164

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Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2

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