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dc.rights.licenseopenen_US
dc.contributor.authorMALYTSKYI, Volodymyr
dc.contributor.authorMOREAU, Juliette
dc.contributor.authorCALLEWAERT, Maite
dc.contributor.authorHENOUMONT, Celine
dc.contributor.authorCADIOU, Cyril
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorFEUILLIE, Cecile
dc.contributor.authorLAURENT, Sophie
dc.contributor.authorMOLINARI, Michael
dc.contributor.authorCHUBURU, Francoise
dc.date.accessioned2024-09-19T07:49:57Z
dc.date.available2024-09-19T07:49:57Z
dc.date.issued2022-03-15
dc.identifier.issn2310-2861en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201673
dc.description.abstractEnHyaluronic acid (HA) was functionalized with a series of amino synthons (octylamine, polyethylene glycol amine, trifluoropropyl amine, rhodamine). Sodium hyaluronate (HAs) was first converted into its protonated form (HAp) and the reaction was conducted in DMSO by varying the initial ratio (−NH2 (synthon)/COOH (HAp)). HA derivatives were characterized by a combination of techniques (FTIR, 1H NMR, 1D diffusion-filtered 19F NMR, DOSY experiments), and degrees of substitution (DSHA) varying from 0.3% to 47% were determined, according to the grafted synthon. Nanohydrogels were then obtained by ionic gelation between functionalized hyaluronic acids and chitosan (CS) and tripolyphosphate (TPP) as a cross-linker. Nanohydrogels for which HA and CS were respectively labeled by rhodamine and fluorescein which are a fluorescent donor-acceptor pair were subjected to FRET experiments to evaluate the stability of these nano-assemblies.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enNanohydrogels–hyaluronic acid–HA-mPEG2000
dc.subject.enFluorinated and fluorescent HA conjugates–hyaluronic acid degree of substitution–diffusion ordered spectroscopy (DOSY)–1D diffusion-filtered 19F NMR–atomic force microscopy–FRET experiments–hyaluronidase–nanohydrogel stability
dc.title.enSynthesis and Characterization of Conjugated Hyaluronic Acids. Application to Stability Studies of Chitosan-Hyaluronic Acid Nanogels Based on Fluorescence Resonance Energy Transfer
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/gels8030182en_US
dc.subject.halChimie/Matériauxen_US
dc.description.sponsorshipEuropeEuropean Regional Development Funden_US
bordeaux.journalGelsen_US
bordeaux.volume8en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Gels&rft.date=2022-03-15&rft.volume=8&rft.issue=3&rft.eissn=2310-2861&rft.issn=2310-2861&rft.au=MALYTSKYI,%20Volodymyr&MOREAU,%20Juliette&CALLEWAERT,%20Maite&HENOUMONT,%20Celine&CADIOU,%20Cyril&rft.genre=article


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