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COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants

dc.rights.licenseopenen_US
hal.structure.identifierGroupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) [CARMAS]
hal.structure.identifierIMRB - VHC/"Viruses-Hepatology-Cancers" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorBAY, Pierre
hal.structure.identifierHôpital Henri Mondor
hal.structure.identifierIMRB - CEPIA/"Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorAUDUREAU, Étienne
hal.structure.identifierEpidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations
dc.contributor.authorPRÉAU, Sébastien
hal.structure.identifierEpidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations
dc.contributor.authorFAVORY, Raphael
hal.structure.identifierCentre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
dc.contributor.authorGUIGON, Aurélie
hal.structure.identifierHôpital Raymond Poincaré (Garches) [GHU AP-HP Université Paris-Saclay]
dc.contributor.authorHEMING, Nicholas
hal.structure.identifierHôpital Ambroise Paré [AP-HP]
dc.contributor.authorGAULT, Elyanne
hal.structure.identifierGroupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) [CARMAS]
hal.structure.identifierHôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorPHAM, Tài
hal.structure.identifierHôpital Paul Brousse
dc.contributor.authorCHAGHOURI, Amal
hal.structure.identifierCentre de Recherche Saint-Antoine [CRSA]
hal.structure.identifierCHU Tenon [AP-HP]
dc.contributor.authorTURPIN, Matthieu
hal.structure.identifierInstitut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
hal.structure.identifierCHU Saint-Antoine [AP-HP]
dc.contributor.authorMORAND-JOUBERT, Laurence
hal.structure.identifierCentre hospitalier Marc Jacquet (Melun)
dc.contributor.authorJOCHMANS, Sébastien
hal.structure.identifierCentre hospitalier Marc Jacquet (Melun)
dc.contributor.authorPITSCH, Aurelia
hal.structure.identifierHôpital Ambroise Paré [AP-HP]
dc.contributor.authorMEIRELES, Sylvie
dc.contributor.authorCONTOU, Damien
dc.contributor.authorHENRY, Amandine
hal.structure.identifierHopital Saint-Louis [AP-HP] [AP-HP]
dc.contributor.authorJOSEPH, Adrien
hal.structure.identifierImmunologie humaine, physiopathologie & immunothérapie [HIPI (UMR_S_976 / U976)]
hal.structure.identifierHopital Saint-Louis [AP-HP] [AP-HP]
dc.contributor.authorCHAIX, Marie Laure
hal.structure.identifierInstitut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)]
hal.structure.identifierHôpital Louis Mourier - AP-HP [Colombes]
dc.contributor.authorUHEL, Fabrice
hal.structure.identifierInstitut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)]
hal.structure.identifierHôpital Louis Mourier - AP-HP [Colombes]
dc.contributor.authorROUX, Damien
hal.structure.identifierInfection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
hal.structure.identifierAP-HP - Hôpital Bichat - Claude Bernard [Paris]
dc.contributor.authorDESCAMPS, Diane
hal.structure.identifierHôpital Saint-Camille [Bry-sur-Marne]
dc.contributor.authorEMERY, Malo
hal.structure.identifierHôpital Saint-Camille [Bry-sur-Marne]
dc.contributor.authorGARCIA-SANCHEZ, Claudio
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
hal.structure.identifierSorbonne Université [SU]
dc.contributor.authorLEVY, David
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorBURREL, Sonia
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
hal.structure.identifierSorbonne Université [SU]
dc.contributor.authorMAYAUX, Julien
hal.structure.identifierDéfaillance Cardiovasculaire Aiguë et Chronique [DCAC]
hal.structure.identifierFrench-Clinical Research Infrastructure Network - F-CRIN [Paris] [Cardiovascular & Renal Clinical Trialists - CRCT]
hal.structure.identifierCardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] [INI-CRCT]
dc.contributor.authorKIMMOUN, Antoine
hal.structure.identifierService de Virologie [CHRU Nancy]
dc.contributor.authorHARTARD, Cédric
hal.structure.identifierHôpital Cochin [AP-HP]
dc.contributor.authorPENE, Frédéric
hal.structure.identifierHôpital Cochin [AP-HP]
dc.contributor.authorROZENBERG, Flore
hal.structure.identifierHôpital Avicenne [AP-HP]
dc.contributor.authorGAUDRY, Stephane
hal.structure.identifierHôpital Avicenne [AP-HP]
dc.contributor.authorBRICHLER, Segolene
hal.structure.identifierCentre d’Etude des Pathologies Respiratoires [Tours] [CEPR - U 1100]
hal.structure.identifierCentre Hospitalier Régional Universitaire de Tours [CHRU Tours]
dc.contributor.authorGUILLON, Antoine
hal.structure.identifierMorphogénèse et antigénicité du VIH, des Virus des Hépatites et Emergents [MAVIVHe]
hal.structure.identifierCentre Hospitalier Régional Universitaire de Tours [CHRU Tours]
dc.contributor.authorHANDALA, Lynda
hal.structure.identifierCHU Rouen
dc.contributor.authorTAMION, Fabienne
hal.structure.identifierCHU Rouen
hal.structure.identifierDynamique Microbienne associée aux Infections Urinaires et Respiratoires [DYNAMICURE]
dc.contributor.authorMOISAN, Alice
hal.structure.identifierAnti-infectieux : supports moléculaires des résistances et innovations thérapeutiques [RESINFIT]
hal.structure.identifierCentre d'Investigation Clinique de Limoges [CIC1435]
dc.contributor.authorDAIX, Thomas
hal.structure.identifierCentre National de Référence des Herpèsvirus [Limoges] [CNR Herpèsvirus]
hal.structure.identifierAnti-infectieux : supports moléculaires des résistances et innovations thérapeutiques [RESINFIT]
dc.contributor.authorHANTZ, Sébastien
hal.structure.identifierCentre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
dc.contributor.authorDELAMAIRE, Flora
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
hal.structure.identifierCentre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
dc.contributor.authorTHIBAULT, Vincent
hal.structure.identifierCHU Louise Michel [Clermont-Ferrand]
dc.contributor.authorSOUWEINE, Bertrand
hal.structure.identifierCHU Louise Michel [Clermont-Ferrand]
dc.contributor.authorHENQUELL, Cécile
hal.structure.identifierService d'immunologie clinique et maladies infectieuses [Hôpitaux universitaires CHU Henri Mondor]
dc.contributor.authorPICARD, Lucile
hal.structure.identifierHôpital Henri Mondor
dc.contributor.authorBOTTEREL, Françoise
hal.structure.identifierHôpital Henri Mondor
hal.structure.identifierIMRB - VHC/"Viruses-Hepatology-Cancers" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorRODRIGUEZ, Christophe
hal.structure.identifierGroupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) [CARMAS]
hal.structure.identifierIMRB - VHC/"Viruses-Hepatology-Cancers" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorMEKONTSO-DESSAP, Armand
hal.structure.identifierHôpital Henri Mondor
hal.structure.identifierIMRB - VHC/"Viruses-Hepatology-Cancers" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorPAWLOTSKY, Jean-Michel
hal.structure.identifierHôpital Henri Mondor
hal.structure.identifierIMRB - VHC/"Viruses-Hepatology-Cancers" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorFOURATI, Slim
hal.structure.identifierGroupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) [CARMAS]
hal.structure.identifierIMRB - VHC/"Viruses-Hepatology-Cancers" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorDE PROST, Nicolas
dc.date.accessioned2024-09-04T14:03:18Z
dc.date.available2024-09-04T14:03:18Z
dc.date.issued2024
dc.identifier.issn2110-5820en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201435
dc.description.abstractEnBACKGROUND: During the first COVID-19 pandemic wave, COVID-19-associated pulmonary aspergillosis (CAPA) has been reported in up to 11-28% of critically ill COVID-19 patients and associated with increased mortality. As new SARS-CoV-2 variants emerged, the characteristics of critically ill COVID-19 patients have evolved, particularly in the era of Omicron. The purpose of this study is to investigate the characteristics of CAPA in the era of new variants. METHODS: This is a prospective multicenter observational cohort study conducted in France in 36 participating intensive care units (ICU), between December 7th, 2021 and April 26th 2023. Diagnosis criteria of CAPA relied on European Confederation of Medical Mycology (ECMM)/International Society for Human and Animal Mycology (ISHAM) consensus criteria. RESULTS: 566 patients were included over the study period. The prevalence of CAPA was 5.1% [95% CI 3.4-7.3], and rose to 9.1% among patients who required invasive mechanical ventilation (IMV). Univariable analysis showed that CAPA patients were more frequently immunosuppressed and required more frequently IMV support, vasopressors and renal replacement therapy during ICU stay than non-CAPA patients. SAPS II score at ICU admission, immunosuppression, and a SARS-CoV-2 Delta variant were independently associated with CAPA in multivariable logistic regression analysis. Although CAPA was not significantly associated with day-28 mortality, patients with CAPA experienced a longer duration of mechanical ventilation and ICU stay. CONCLUSION: This study contributes valuable insights into the prevalence, characteristics, and outcomes of CAPA in the era of Delta and Omicron variants. We report a lower prevalence of CAPA (5.1%) among critically-ill COVID-19 patients than previously reported, mainly affecting intubated-patients. Duration of mechanical ventilation and ICU stay were significantly longer in CAPA patients.
dc.language.isoENen_US
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enAcute respiratory distress syndrome
dc.subject.enCOVID-19
dc.subject.enCOVID-19 associated pulmonary aspergillosis
dc.subject.enIntensive care unit
dc.subject.enInvasive pulmonary aspergillosis
dc.subject.enOmicron
dc.subject.enSARS-CoV-2
dc.title.enCOVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s13613-024-01296-0en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed38658426en_US
bordeaux.journalAnnals of Intensive Careen_US
bordeaux.page65en_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue1en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04577615
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
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