Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection
| dc.rights.license | open | en_US |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | CABRAL-PICCIN, Mariela P. | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | PAPAGNO, Laura | |
| dc.contributor.author | LAHAYE, X. | |
| dc.contributor.author | PERDOMO-CELIS, F. | |
| dc.contributor.author | VOLANT, S. | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | WHITE, Eoghann | |
| dc.contributor.author | MONCEAUX, V. | |
| dc.contributor.author | LLEWELLYN-LACEY, S. | |
| dc.contributor.author | FROMENTIN, R. | |
| dc.contributor.author | PRICE, D.A. | |
| dc.contributor.author | CHOMONT, N. | |
| dc.contributor.author | MANEL, N. | |
| dc.contributor.author | SAEZ-CIRION, A. | |
| dc.contributor.author | APPAY, V. | |
| dc.date.accessioned | 2024-09-03T07:41:45Z | |
| dc.date.available | 2024-09-03T07:41:45Z | |
| dc.date.issued | 2023 | |
| dc.identifier.issn | 2352-3964 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/201399 | |
| dc.description.abstractEn | Background: CD8+ T cells equipped with a full arsenal of antiviral effector functions are critical for effective immune control of HIV-1. It has nonetheless remained unclear how best to elicit such potent cellular immune responses in the context of immunotherapy or vaccination. HIV-2 has been associated with milder disease manifestations and more commonly elicits functionally replete virus-specific CD8+ T cell responses compared with HIV-1. We aimed to learn from this immunological dichotomy and to develop informed strategies that could enhance the induction of robust CD8+ T cell responses against HIV-1. Methods: We developed an unbiased in vitro system to compare the de novo induction of antigen-specific CD8+ T cell responses after exposure to HIV-1 or HIV-2. The functional properties of primed CD8+ T cells were assessed using flow cytometry and molecular analyses of gene transcription. Findings: HIV-2 primed functionally optimal antigen-specific CD8+ T cells with enhanced survival properties more effectively than HIV-1. This superior induction process was dependent on type I interferons (IFNs) and could be mimicked via the adjuvant delivery of cyclic GMP-AMP (cGAMP), a known agonist of the stimulator of interferon genes (STING). CD8+ T cells elicited in the presence of cGAMP were polyfunctional and highly sensitive to antigen stimulation, even after priming from people living with HIV-1. Interpretation: HIV-2 primes CD8+ T cells with potent antiviral functionality by activating the cyclic GMP-AMP synthase (cGAS)/STING pathway, which results in the production of type I IFNs. This process may be amenable to therapeutic development via the use of cGAMP or other STING agonists to bolster CD8+ T cell-mediated immunity against HIV-1. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | CD8(+) T cells | |
| dc.subject.en | HIV-1 | |
| dc.subject.en | HIV-2 | |
| dc.subject.en | STING; Type I IFN | |
| dc.title.en | Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.ebiom.2023.104557 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 37058769 | en_US |
| bordeaux.journal | EBioMedicine | en_US |
| bordeaux.volume | 91 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY-NC-ND | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=EBioMedicine&rft.date=2023&rft.volume=91&rft.eissn=2352-3964&rft.issn=2352-3964&rft.au=CABRAL-PICCIN,%20Mariela%20P.&PAPAGNO,%20Laura&LAHAYE,%20X.&PERDOMO-CELIS,%20F.&VOLANT,%20S.&rft.genre=article |
