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Multicenter prospective observational study of dupilumab-induced ocular events in atopic dermatitis patients

dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorCOSTEDOAT, Ingrid
dc.contributor.authorWALLAERT, M.
dc.contributor.authorGAULTIER, A.
dc.contributor.authorVASSEUR, R.
dc.contributor.authorVANHAECKE, C.
dc.contributor.authorVIGUIER, M.
dc.contributor.authorCORDELETTE, C.
dc.contributor.authorDENOYER, A.
dc.contributor.authorFERRIER LE BOUËDEC, M.-C.
dc.contributor.authorCOUTU, A.
dc.contributor.authorLAMIAUX, M.
dc.contributor.authorTRAN, T.H.C.
dc.contributor.authorLACOUR, J.P.
dc.contributor.authorELMALEH, V.
dc.contributor.authorTETART, F.
dc.contributor.authorGUEUDRY, J.
dc.contributor.authorTAUBER, M.
dc.contributor.authorGIORDANO-LABADIE, F.
dc.contributor.authorCASSAGNE, M.
dc.contributor.authorNOSBAUM, A.
dc.contributor.authorOUILHON, C.
dc.contributor.authorJACHIET, M.
dc.contributor.authorTADAYONI, R.
dc.contributor.authorDEZOTEUX, F.
dc.contributor.authorSTAUMONT-SALLE, D.
dc.contributor.authorBOULEAU, J.
dc.contributor.authorLABALETTE, P.
dc.contributor.authorDOAN, S.
dc.contributor.authorSORIA, A.
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorMORTEMOUSQUE, Bruno
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorSENESCHAL, Julien
dc.contributor.authorBARBAROT, S.
dc.contributor.authorFRENCH ATOPIC DERMATITIS NETWORK FROM THE GROUPE DE RECHERCHE SUR L'ECZEMA ATOPIQUE (GREAT), France
dc.date.accessioned2024-08-30T08:27:38Z
dc.date.available2024-08-30T08:27:38Z
dc.date.issued2023
dc.identifier.issn0926-9959en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201364
dc.description.abstractEnBackground: Although ocular adverse events are frequent in AD patients treated with dupilumab, their characterization remains limited due to a lack of prospective studies with a systematic ophthalmological examination. Objective: To examine the incidence, characteristics and risk factors of dupilumab-induced ocular adverse events. Methods: A prospective, multicenter, and real-life study in adult AD patients treated with dupilumab. Results: At baseline, 27 out of 181 patients (14.9%) had conjunctivitis. At week 16 (W16), 25 out of 27 had improved their conjunctivitis and 2 remained stable and 34 out of 181 patients (18.7%) had dupilumab-induced blepharoconjunctivitis: either de novo (n = 32) or worsening of underlying blepharoconjunctivitis (n = 2). Most events (27/34; 79.4%) were moderate. A multivariate analysis showed that head and neck AD (OR = 7.254; 95%CI [1.938–30.07]; p = 0.004), erythroderma (OR = 5.635; 95%CI [1.635–21.50]; p = 0.007) and the presence of dry eye syndrome at baseline (OR = 3.51; 95%CI [3.158–13.90]; p = 0.031) were independent factors associated with dupilumab-induced blepharoconjunctivitis. Limitations: Our follow-up period was 16 weeks and some late-onset time effects may still occur. Conclusion: This study showed that most dupilumab-induced blepharoconjunctivitis cases are de novo. AD severity and conjunctivitis at baseline were not found to be associated risk factors in this study. © 2023 European Academy of Dermatology and Venereology.
dc.language.isoENen_US
dc.title.enMulticenter prospective observational study of dupilumab-induced ocular events in atopic dermatitis patients
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/jdv.18932en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed36732052en_US
bordeaux.journalJournal of the European Academy of Dermatology and Venereologyen_US
bordeaux.page1056-1063en_US
bordeaux.volume37en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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