Triap1 upregulation promotes escape from mitotic-slippage-induced G1 arrest
| dc.rights.license | open | en_US |
| dc.contributor.author | PAVANI, Mattia | |
| dc.contributor.author | CHIROLI, Elena | |
| dc.contributor.author | CANCRINI, Camilla | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | GROSS, Fridolin | |
| dc.contributor.author | BONAIUTI, P. | |
| dc.contributor.author | VILLA, S. | |
| dc.contributor.author | GIAVAZZI, F. | |
| dc.contributor.author | MATAFORA, V. | |
| dc.contributor.author | BACHI, A. | |
| dc.contributor.author | FAVA, L.L. | |
| dc.contributor.author | LISCHETTI, T. | |
| dc.contributor.author | CILIBERTO, A. | |
| dc.date.accessioned | 2024-08-29T13:25:07Z | |
| dc.date.available | 2024-08-29T13:25:07Z | |
| dc.date.issued | 2023 | |
| dc.identifier.issn | 2211-1247 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/201354 | |
| dc.description.abstractEn | Drugs targeting microtubules rely on the mitotic checkpoint to arrest cell proliferation. The prolonged mitotic arrest induced by such drugs is followed by a G1 arrest. Here, we follow for several weeks the fate of G1-arrested human cells after treatment with nocodazole. We find that a small fraction of cells escapes from the arrest and resumes proliferation. These escaping cells experience reduced DNA damage and p21 activation. Cells surviving treatment are enriched for anti-apoptotic proteins, including Triap1. Increasing Triap1 levels allows cells to survive the first treatment with reduced DNA damage and lower levels of p21; accordingly, decreasing Triap1 re-sensitizes cells to nocodazole. We show that Triap1 upregulation leads to the retention of cytochrome c in the mitochondria, opposing the partial activation of caspases caused by nocodazole. In summary, our results point to a potential role of Triap1 upregulation in the emergence of resistance to drugs that induce prolonged mitotic arrest. © 2023 The Author(s) | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Cell cycle | |
| dc.subject.en | Mitosis | |
| dc.subject.en | Sublethal caspase activation | |
| dc.subject.en | Microtubule targeting drugs | |
| dc.title.en | Triap1 upregulation promotes escape from mitotic-slippage-induced G1 arrest | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.celrep.2023.112215 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 36917609 | en_US |
| bordeaux.journal | Cell Reports | en_US |
| bordeaux.volume | 42 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04681320 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-08-29T13:25:11Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | CC BY-NC-ND | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Reports&rft.date=2023&rft.volume=42&rft.issue=3&rft.eissn=2211-1247&rft.issn=2211-1247&rft.au=PAVANI,%20Mattia&CHIROLI,%20Elena&CANCRINI,%20Camilla&GROSS,%20Fridolin&BONAIUTI,%20P.&rft.genre=article |
