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Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing

dc.rights.licenseopenen_US
dc.contributor.authorDU PREEZ, Andrea
dc.contributor.authorLEFEVRE-ARBOGAST, Sophie
dc.contributor.authorGONZALEZ-DOMINGUEZ, Raul
dc.contributor.authorHOUGHTON, Vikki
dc.contributor.authorDE LUCIA, Chiara
dc.contributor.authorLEE, Hyunah
dc.contributor.authorLOW, Dorrain Y
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFEART, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cecile
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST LIMA, Cecile
dc.contributor.authorPALLAS, Merce
dc.contributor.authorSANCHEZ-PLA, Alex
dc.contributor.authorURPI-SARDA, Mireia
dc.contributor.authorRUIGROK, Silvie R
dc.contributor.authorALTENDORFER, Barbara
dc.contributor.authorAIGNER, Ludwig
dc.contributor.authorLUCASSEN, Paul J
dc.contributor.authorKOROSI, Aniko
dc.contributor.authorMANACH, Claudine
dc.contributor.authorANDRES-LACUEVA, Cristina
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorTHURET, Sandrine
dc.date.accessioned2024-08-22T12:45:32Z
dc.date.available2024-08-22T12:45:32Z
dc.date.issued2024-05-11
dc.identifier.issn1468-2834en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201260
dc.description.abstractEnHippocampal neurogenesis (HN) occurs throughout the life course and is important for memory and mood. Declining with age, HN plays a pivotal role in cognitive decline (CD), dementia, and late-life depression, such that altered HN could represent a neurobiological susceptibility to these conditions. Pertinently, dietary patterns (e.g., Mediterranean diet) and/or individual nutrients (e.g., vitamin D, omega 3) can modify HN, but also modify risk for CD, dementia, and depression. Therefore, the interaction between diet/nutrition and HN may alter risk trajectories for these ageing-related brain conditions. Using a subsample (n = 371) of the Three-City cohort-where older adults provided information on diet and blood biobanking at baseline and were assessed for CD, dementia, and depressive symptomatology across 12 years-we tested for interactions between food consumption, nutrient intake, and nutritional biomarker concentrations and neurogenesis-centred susceptibility status (defined by baseline readouts of hippocampal progenitor cell integrity, cell death, and differentiation) on CD, Alzheimer's disease (AD), vascular and other dementias (VoD), and depressive symptomatology, using multivariable-adjusted logistic regression models. Increased plasma lycopene concentrations (OR [95% CI] = 1.07 [1.01, 1.14]), higher red meat (OR [95% CI] = 1.10 [1.03, 1.19]), and lower poultry consumption (OR [95% CI] = 0.93 [0.87, 0.99]) were associated with an increased risk for AD in individuals with a neurogenesis-centred susceptibility. Increased vitamin D consumption (OR [95% CI] = 1.05 [1.01, 1.11]) and plasma gamma-tocopherol concentrations (OR [95% CI] = 1.08 [1.01, 1.18]) were associated with increased risk for VoD and depressive symptomatology, respectively, but only in susceptible individuals. This research highlights an important role for diet/nutrition in modifying dementia and depression risk in individuals with a neurogenesis-centred susceptibility.
dc.description.sponsorshipIdentification of dietary modulators of cognitive ageing and brain plasticity and proof of concept of efficacy for preventing-reversing cognitive declineen_US
dc.description.sponsorshipUniversity of Bordeaux Graduate School in Digital Public Healthen_US
dc.description.sponsorshipCOGINUT : Cognition, anti-oxydants, acides gras: approche interdisciplinaire du rôle de la nutrition dans le vieillissement du cerveau - ANR-06-PNRA-0005en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCognitive decline
dc.subject.enDementia
dc.subject.enDiet
dc.subject.enHippocampal neurogenesis
dc.subject.enLate-life depression
dc.subject.enOlder people
dc.title.enAssociation of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing
dc.title.alternativeAge Ageingen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ageing/afae042en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38745492en_US
bordeaux.journalAge and Ageingen_US
bordeaux.pageII47-II59en_US
bordeaux.volume53en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issueSuppl 2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDSanofien_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDCaisse nationale de solidarité pour l'autonomieen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.identifier.funderIDFondation Plan Alzheimeren_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Age%20and%20Ageing&rft.date=2024-05-11&rft.volume=53&rft.issue=Suppl%202&rft.spage=II47-II59&rft.epage=II47-II59&rft.eissn=1468-2834&rft.issn=1468-2834&rft.au=DU%20PREEZ,%20Andrea&LEFEVRE-ARBOGAST,%20Sophie&GONZALEZ-DOMINGUEZ,%20Raul&HOUGHTON,%20Vikki&DE%20LUCIA,%20Chiara&rft.genre=article


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