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An Elastin-derived composite matrix for enhanced vascularized and innervated bone tissue reconstruction: from material development to preclinical evaluation.

dc.rights.licenseopenen_US
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorMAHMOUDI, Nadia
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorROQUE, Micaela
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorPAIVA DOS SANTOS, Bruno
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorOLIVEIRA, Hugo
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSIADOUS, Robin
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorREY, Sylvie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorGARANGER, Elisabeth
IDREF: 089451740
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sébastien
hal.structure.identifierService de chirurgie maxillo-faciale et stomatologie [CHU Bordeaux]
hal.structure.identifierCHU Bordeaux
dc.contributor.authorCATROS, Sylvain
ORCID: 0000-0002-3419-3467
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorGARBAY, Bertrand
IDREF: 033777551
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorAMÉDÉE VILAMITJANA, Joëlle
dc.date.accessioned2024-08-19T14:25:02Z
dc.date.available2024-08-19T14:25:02Z
dc.date.issued2024-04-23
dc.identifier.issn2192-2659en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201175
dc.description.abstractEnDespite progress in bone tissue engineering, reconstruction of large bone defects remains an important clinical challenge. Here, we developed a biomaterial designed to recruit bone cells, endothelial cells, and neuronal fibers within the same matrix, enabling bone tissue regeneration. The bioactive matrix is based on modified elastin-like polypeptides (ELPs) grafted with laminin-derived adhesion peptides IKVAV and YIGSR, and the SNA15 peptide for retention of hydroxyapatite (HA) particles. The composite matrix shows suitable porosity, interconnectivity, biocompatibility for endothelial cells, and the ability to support neurites outgrowth by sensory neurons. Subcutaneous implantation led to the formation of osteoid tissue, characterized by the presence of bone cells, vascular networks, and neuronal structures, while minimizing inflammation. Using a rat femoral condyle defect model, we performed longitudinal micro-CT analysis, which demonstrates a significant increase in the volume of mineralized tissue when using the ELP-based matrix compared to empty defects and a commercially available control (Collapat). Furthermore, visible blood vessel networks and nerve fibers are observed within the lesions after a period of two weeks. By incorporating multiple key components that support cell growth, mineralization, and tissue integration, this ELP-based composite matrix provides a holistic and versatile solution to enhance bone tissue regeneration. This article is protected by copyright. All rights reserved.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.title.enAn Elastin-derived composite matrix for enhanced vascularized and innervated bone tissue reconstruction: from material development to preclinical evaluation.
dc.title.alternativeAdv Healthc Materen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/adhm.202303765en_US
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Biomatériauxen_US
dc.identifier.pubmed38651610en_US
bordeaux.journalAdvanced Healthcare Materialsen_US
bordeaux.page2303765en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629en_US
bordeaux.hal.laboratoriesTissue Bioengineering Laboratory (BioTis), Inserm U1026, University of Bordeauxen_US
bordeaux.hal.laboratoriesBioingénierie tissulaire (BIOTIS) - Inserm U1026, University of Bordeauxen_US
bordeaux.issue18en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04672983
hal.version1
hal.date.transferred2024-08-19T14:25:07Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Advanced%20Healthcare%20Materials&rft.date=2024-04-23&rft.volume=13&rft.issue=18&rft.spage=2303765&rft.epage=2303765&rft.eissn=2192-2659&rft.issn=2192-2659&rft.au=MAHMOUDI,%20Nadia&ROQUE,%20Micaela&PAIVA%20DOS%20SANTOS,%20Bruno&OLIVEIRA,%20Hugo&SIADOUS,%20Robin&rft.genre=article


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