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Simultaneous monitoring of single cell and of micro-organ activity by PEDOT:PSS covered multi-electrode arrays

dc.rights.licenseopen
hal.structure.identifierEcole Nationale Supérieure des Mines de Saint-Etienne, Centre Microélectronique de Provence (EMSE-CMP)
dc.contributor.authorKOUTSOURAS, Dimitrios
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorPERRIER, Romain
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 4 LCPO : Polymer Materials for Electronic, Energy, Information and Communication Technologies
dc.contributor.authorVILLARROEL MARQUEZ, Ariana Alejandra
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorPIROG, Antoine
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorPEDRAZA, Eileen
hal.structure.identifierTeam 4 LCPO : Polymer Materials for Electronic, Energy, Information and Communication Technologies
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorCLOUTET, Eric
IDREF: 151048681
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorRENAUD, Sylvie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorRAOUX, Matthieu
hal.structure.identifierEcole Nationale Supérieure des Mines de Saint-Etienne, Centre Microélectronique de Provence (EMSE-CMP)
hal.structure.identifierEcole Natl Super Mines, Dept Bioelect
dc.contributor.authorMALLIARAS, George G.
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLANG, Jochen
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2017
dc.identifier.issn0928-4931
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20104
dc.description.abstractEnContinuous and long-term monitoring of cellular and micro-organ activity is required for new insights intophysiology and novel technologies such as Organs-on-Chip. Moreover, recent advances in stem cell technologyand especially in the field of diabetes call for non-invasive approaches in quality testing of the large quantities ofsurrogate pancreatic islets to be generated. Electrical activity of such a micro-organ results in single cell actionpotentials (APs) of high frequency and in low frequency changes in local field potentials (slow potentials or SPs),reflecting coupled cell activity and overall organ physiology. Each of them is indicative of different physiologicalstages in islet activation. Action potentials in islets are of small amplitude and very difficult to detect. The use ofPEDOT:PSS to coat metal electrodes is expected to reduce noise and results in a frequency-dependent change inimpedance, as shown here. Whereas detection of high-frequency APs improves, low frequency SPs are less welldetected which is, however, an acceptable trade off in view of the strong amplitude of SPs. Using a dedicatedsoftware, recorded APs and SPs can be automatically diagnosed and analyzed. Concomitant capture of the twosignals will considerably increase the diagnostic power of monitoring islets and islet surrogates in fundamentalresearch as well as drug screening or the use of islets as biosensors.
dc.language.isoen
dc.publisherElsevier
dc.subject.enBioelectronics
dc.subject.enBiosensor
dc.subject.enPEDOT:PSS
dc.subject.enDiabetes
dc.subject.enIslets
dc.subject.enPancreatic beta-cells
dc.title.enSimultaneous monitoring of single cell and of micro-organ activity by PEDOT:PSS covered multi-electrode arrays
dc.typeArticle de revue
dc.identifier.doi10.1016/j.msec.2017.07.028
dc.subject.halChimie/Polymères
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalMaterials Science and Engineering: C
bordeaux.page84-89
bordeaux.volume81
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01578781
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01578781v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Materials%20Science%20and%20Engineering:%20C&rft.date=2017&rft.volume=81&rft.spage=84-89&rft.epage=84-89&rft.eissn=0928-4931&rft.issn=0928-4931&rft.au=KOUTSOURAS,%20Dimitrios&PERRIER,%20Romain&VILLARROEL%20MARQUEZ,%20Ariana%20Alejandra&PIROG,%20Antoine&PEDRAZA,%20Eileen&rft.genre=article


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