| hal.structure.identifier | Unité de Nutrition Humaine [UNH] | |
| hal.structure.identifier | Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE] | |
| dc.contributor.author | AUDEMARD, Juliette | |
| hal.structure.identifier | Molécules de Communication et Adaptation des Micro-organismes [MCAM] | |
| hal.structure.identifier | Muséum national d'Histoire naturelle [MNHN] | |
| dc.contributor.author | HALARY, Sébastien | |
| hal.structure.identifier | Station biologique de Roscoff = Roscoff Marine Station [SBR] | |
| hal.structure.identifier | Laboratoire de Biologie Intégrative des Modèles Marins [LBI2M] | |
| dc.contributor.author | MARKOV, Gabriel | |
| hal.structure.identifier | Dynamics, Logics and Inference for biological Systems and Sequences [Dyliss] | |
| dc.contributor.author | GOT, Jeanne | |
| hal.structure.identifier | Dynamics, Logics and Inference for biological Systems and Sequences [Dyliss] | |
| dc.contributor.author | SIEGEL, Anne | |
| hal.structure.identifier | Plateforme Exploration du Métabolisme [PFEM] | |
| hal.structure.identifier | Unité de Nutrition Humaine [UNH] | |
| dc.contributor.author | LEFEBVRE, Marie | |
| hal.structure.identifier | Institut d'écologie et des sciences de l'environnement de Paris [iEES Paris] | |
| dc.contributor.author | LELOUP, Julie | |
| hal.structure.identifier | Muséum national d'Histoire naturelle [MNHN] | |
| hal.structure.identifier | Molécules de Communication et Adaptation des Micro-organismes [MCAM] | |
| dc.contributor.author | MARIE, Benjamin | |
| hal.structure.identifier | Plateforme Bordeaux Metabolome | |
| hal.structure.identifier | Ecosystèmes aquatiques et changements globaux [UR EABX] | |
| dc.contributor.author | CREUSOT, Nicolas | |
| hal.structure.identifier | Unité de Nutrition Humaine [UNH] | |
| hal.structure.identifier | MetaboHUB-Clermont | |
| hal.structure.identifier | Plateforme Exploration du Métabolisme [PFEM] | |
| dc.contributor.author | DIEME, Binta | |
| hal.structure.identifier | Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE] | |
| dc.contributor.author | FRIOUX, Cleḿence | |
| dc.date.created | 2024-06 | |
| dc.date.issued | 2024 | |
| dc.date.conference | 2024-06-25 | |
| dc.description.abstractEn | In the context of global warming and eutrophication of waters, harmful algal blooms are an international concern. Warm weather and nutrients abundance feed cyanobacterial species, whose growth goes alongside biodiversity degradation, health risk for animals and humans and high economical repercussions (e.g. water treatment, recreational areas closure, impacts on agri-food). Microcystis, a genus of freshwater cyanobacteria, is described as one of the most pervasive bloom forming species. A subset of Microcystis strains' ability to produce the microcystin hepatotoxin, microcystin-LR (MC-LR) being the most harmful and common, make their bloom a certain threat. The biochemical and ecological mechanisms behind those remain relatively unknown, motivating the use of in silico systems biology approaches to propose mechanistic hypotheses. Biochemical interactions between Microcystis and heterotrophic bacteria within the phycosphere may contribute to bloom formation particularly through optimal management of nutrient resources (e.g. recycling of organic matter, cross-feeding). We aim to analyse the mechanisms underlying the metabolic activity of cyanobacteria and their associated symbionts using metabolic models. Genome-scale metabolic networks (GSMNs) gather all biochemical reactions linked with the genes of a genome, and can be reconstructed automatically and feed metabolic models to predict the behaviour of organisms, or communities in their environment. Our work’s objective decomposes into three parts i) assessing the ability of GSMNs reconstruction to capture Microcystis strains production of toxins, ii) compare the metabolic functions carried by a set of Microcystis strains iii) analyse jointly the metabolism of the cyanobacteria and their communities across several lake samples in the context of bloom formation. | |
| dc.language.iso | en | |
| dc.rights.uri | http://creativecommons.org/licenses/by/ | |
| dc.subject.en | Systems biology | |
| dc.subject.en | Microbial communities | |
| dc.subject.en | Metabolic modelling | |
| dc.subject.en | Freshwater cyanobacteria | |
| dc.subject.en | Microcystin | |
| dc.title.en | Metagenome-scale metabolic modelling for the characterization of cross-feeding interactions in Microcystis-associated microbial communities, in the context of freshwater cyanobacterial blooms | |
| dc.type | Autre communication scientifique (congrès sans actes - poster - séminaire...) | |
| dc.subject.hal | Informatique [cs]/Bio-informatique [q-bio.QM] | |
| bordeaux.page | 1-1 | |
| bordeaux.conference.title | JOBIM 2024 - Journées Ouvertes en Biologie, Informatique et Mathématiques | |
| bordeaux.country | FR | |
| bordeaux.conference.city | Toulouse | |
| bordeaux.peerReviewed | non | |
| hal.identifier | hal-04654522 | |
| hal.version | 1 | |
| hal.invited | non | |
| hal.proceedings | non | |
| hal.conference.end | 2024-06-28 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-04654522v1 | |
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