Endogenous noise of neocortical neurons correlates with atypical sensory response variability in the Fmr1 −/y mouse model of autism
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | AZHIKKATTUPARAMBIL BHASKARAN, Arjun | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | GAUVRIT, Théo | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | VYAS, Yukti | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | BONY, Guillaume | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | GINGER, Mélanie | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | FRICK, Andreas | |
| dc.date.accessioned | 2024-07-19T13:36:15Z | |
| dc.date.available | 2024-07-19T13:36:15Z | |
| dc.date.issued | 2023-11-30 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/201039 | |
| dc.description.abstractEn | Excessive neural variability of sensory responses is a hallmark of atypical sensory processing in autistic individuals with cascading effects on other core autism symptoms but unknown neurobiological substrate. Here, by recording neocortical single neuron activity in a well-established mouse model of Fragile X syndrome and autism, we characterized atypical sensory processing and probed the role of endogenous noise sources in exaggerated response variability in males. The analysis of sensory stimulus evoked activity and spontaneous dynamics, as well as neuronal features, reveals a complex cellular and network phenotype. Neocortical sensory information processing is more variable and temporally imprecise. Increased trial-by-trial and inter-neuronal response variability is strongly related to key endogenous noise features, and may give rise to behavioural sensory responsiveness variability in autism. We provide a novel preclinical framework for understanding the sources of endogenous noise and its contribution to core autism symptoms, and for testing the functional consequences for mechanism-based manipulation of noise. © 2023, The Author(s). | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Autistic Disorder | |
| dc.subject.en | Disease Models | |
| dc.subject.en | Animal | |
| dc.subject.en | Fragile X Mental Retardation Protein | |
| dc.subject.en | Fragile X Syndrome | |
| dc.subject.en | Male | |
| dc.subject.en | Mice | |
| dc.subject.en | Knockout | |
| dc.subject.en | Neocortex | |
| dc.subject.en | Neurons | |
| dc.subject.en | Sensation | |
| dc.subject.en | Fmr1 protein | |
| dc.subject.en | Mouse | |
| dc.title.en | Endogenous noise of neocortical neurons correlates with atypical sensory response variability in the Fmr1 −/y mouse model of autism | |
| dc.title.alternative | Nat Commun | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41467-023-43777-z | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 38036566 | en_US |
| bordeaux.journal | Nature Communications | en_US |
| bordeaux.volume | 14 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Plasticité Corticale | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| hal.identifier | hal-04654386 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-07-19T13:36:18Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2023-11-30&rft.volume=14&rft.issue=1&rft.au=AZHIKKATTUPARAMBIL%20BHASKARAN,%20Arjun&GAUVRIT,%20Th%C3%A9o&VYAS,%20Yukti&BONY,%20Guillaume&GINGER,%20M%C3%A9lanie&rft.genre=article |
