Antiplatelet and anticoagulant therapies in hereditary hemorrhagic telangiectasia: A large French cohort study (RETROPLACO℡)
| dc.rights.license | open | en_US |
| dc.contributor.author | GROBOST, Vincent | |
| dc.contributor.author | HAMMI, Sami | |
| dc.contributor.author | PEREIRA, Bruno | |
| dc.contributor.author | GUILHEM, Alexandre | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | DUFFAU, Pierre | |
| dc.contributor.author | SEGUIER, J. | |
| dc.contributor.author | PARROT, A. | |
| dc.contributor.author | GAUTIER, G. | |
| dc.contributor.author | ALRIC, L. | |
| dc.contributor.author | KERJOUAN, M. | |
| dc.contributor.author | LE GUILLOU, X. | |
| dc.contributor.author | SIMON, D. | |
| dc.contributor.author | CHAUSSAVOINE, L. | |
| dc.contributor.author | RONDEAU-LUTZ, M. | |
| dc.contributor.author | LEGUY-SEGUIN, V. | |
| dc.contributor.author | DELAGRANGE, L. | |
| dc.contributor.author | LAVIGNE, C. | |
| dc.contributor.author | MAILLARD, H. | |
| dc.contributor.author | DUPUIS-GIROD, S. | |
| dc.contributor.author | GROUP, French HHT | |
| dc.date.accessioned | 2024-07-05T07:04:07Z | |
| dc.date.available | 2024-07-05T07:04:07Z | |
| dc.date.issued | 2023-07 | |
| dc.identifier.issn | 0049-3848 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/200753 | |
| dc.description.abstractEn | Background It is unclear whether hereditary hemorrhagic telangiectasia (HHT) patients can tolerate antithrombotic therapies (AT) including antiplatelet (AP) and/or anticoagulant (AC) agents. Objectives Primary endpoint was tolerance to AT in HHT. Secondary endpoints were to identify factors associated with major bleeding events (MBE) and premature discontinuation of AT. Methods Retrospective multicenter study in French national HHT Registry patients exposed to AT. Results We included 126 patients with 180 courses of AT. Median follow-up was 24 [11–52] months. Mean age was 65.6 ± 13.1 years. The first 3 months of AT exposure had an increased risk of hospitalization for hemorrhage (p < 0.001) and transfusions (p < 0.001). MBE (n = 63) occurred more frequently in the first 3 months of AT exposure (p < 0.001). Premature discontinuation of AT occurred in 61 cases. Rate of premature discontinuation was 29 % under both AP and AT therapy but significantly higher under dual AP therapy (n = 4/7, 57 % p = 0.008). Risk factors for MBE were: age ≥ 60 years (HR 2.34 [1.12;4.87], p = 0.023), prior hospitalization in the 3 months before starting AT for hemorrhage (HR 3.59 [1.93;6.66], p < 0.001) or transfusion (HR 3.15 [1.61;6.18], p = 0.001), previous history of gastro-intestinal bleeding (HR 2.71 [1.57;4.65], p < 0.001) or MBE (HR 4.62 [2.68;7.98], p < 0.001). Frequency of MBE did not differ between groups except for a higher risk in the dual AP group (HR 3.92 [1.37;11.22], p = 0.011). Conclusion Tolerance of AC or AP therapy was similar in HHT population but not dual AP therapy. We identified risk factors for MBE occurrence or premature discontinuation under AT. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Anticoagulant | |
| dc.subject.en | Antiplatelet | |
| dc.subject.en | Direct oral anticoagulant | |
| dc.subject.en | Hereditary hemorrhagic telangiectasia | |
| dc.subject.en | Major bleeding event | |
| dc.title.en | Antiplatelet and anticoagulant therapies in hereditary hemorrhagic telangiectasia: A large French cohort study (RETROPLACO℡) | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.thromres.2023.07.001 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 37437516 | en_US |
| bordeaux.journal | Thrombosis Research | en_US |
| bordeaux.page | 107-113 | en_US |
| bordeaux.volume | 229 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04636068 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-07-05T07:04:11Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Thrombosis%20Research&rft.date=2023-07&rft.volume=229&rft.spage=107-113&rft.epage=107-113&rft.eissn=0049-3848&rft.issn=0049-3848&rft.au=GROBOST,%20Vincent&HAMMI,%20Sami&PEREIRA,%20Bruno&GUILHEM,%20Alexandre&DUFFAU,%20Pierre&rft.genre=article |
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