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dc.rights.licenseopenen_US
dc.contributor.authorSCHERLINGER, Marc
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorRICHEZ, Christophe
dc.contributor.authorTSOKOS, George C
dc.contributor.authorBOILARD, Eric
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorBLANCO, Patrick
dc.date.accessioned2024-06-28T07:18:40Z
dc.date.available2024-06-28T07:18:40Z
dc.date.issued2023-01
dc.identifier.issn1474-1733en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200681
dc.description.abstractEnImmune-mediated inflammatory diseases (IMIDs) are characterized by excessive and uncontrolled inflammation and thrombosis, both of which are responsible for organ damage, morbidity and death. Platelets have long been known for their role in primary haemostasis, but they are now also considered to be components of the immune system and to have a central role in the pathogenesis of IMIDs. In patients with IMIDs, platelets are activated by disease-specific factors, and their activation often reflects disease activity. Here we summarize the evidence showing that activated platelets have an active role in the pathogenesis and the progression of IMIDs. Activated platelets produce soluble factors and directly interact with immune cells, thereby promoting an inflammatory phenotype. Furthermore, platelets participate in tissue injury and promote abnormal tissue healing, leading to fibrosis. Targeting platelet activation and targeting the interaction of platelets with the immune system are novel and promising therapeutic strategies in IMIDs. © 2023, Springer Nature Limited.
dc.language.isoENen_US
dc.title.enThe role of platelets in immune-mediated inflammatory diseases
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41577-023-00834-4en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed36707719en_US
bordeaux.journalNature Reviews Immunologyen_US
bordeaux.page495-510en_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
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hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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