SCHERLINGER, Marc; RICHEZ, Christophe; TSOKOS, George C; BOILARD, Eric; BLANCO, Patrick

doi:10.1038/s41577-023-00834-4

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

TSOKOS, George C

Langue

Article de revue

Ce document a été publié dans

Nature Reviews Immunology. 2023-01, vol. 23, n° 8, p. 495-510

Résumé en anglais

Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and uncontrolled inflammation and thrombosis, both of which are responsible for organ damage, morbidity and death. Platelets have long been known for their role in primary haemostasis, but they are now also considered to be components of the immune system and to have a central role in the pathogenesis of IMIDs. In patients with IMIDs, platelets are activated by disease-specific factors, and their activation often reflects disease activity. Here we summarize the evidence showing that activated platelets have an active role in the pathogenesis and the progression of IMIDs. Activated platelets produce soluble factors and directly interact with immune cells, thereby promoting an inflammatory phenotype. Furthermore, platelets participate in tissue injury and promote abnormal tissue healing, leading to fibrosis. Targeting platelet activation and targeting the interaction of platelets with the immune system are novel and promising therapeutic strategies in IMIDs. © 2023, Springer Nature Limited.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/200681

DOI

http://dx.doi.org/10.1038/s41577-023-00834-4

Unités de recherche

ImmunoConcEpT - UMR 5164

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

The role of platelets in immune-mediated inflammatory diseases

Langue

Ce document a été publié dans

Résumé en anglais

URI

DOI

Unités de recherche