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Humoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: a French nationwide multicenter cohort study - ANRS0001s COV-POPART
dc.rights.license | open | en_US |
dc.contributor.author | LOUBET, Paul | |
dc.contributor.author | LELIEVRE, Jean-Daniel | |
dc.contributor.author | FRANCOIS, Alexis | |
dc.contributor.author | BOTELHO-NEVERS, Elisabeth | |
dc.contributor.author | CHIDIAC, Christian | |
dc.contributor.author | CHIRIO, David | |
dc.contributor.author | DUBEE, Vincent | |
dc.contributor.author | DUSSOL, Bertrand | |
dc.contributor.author | GALTIER, Florence | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | HESSAMFAR, Mojgan | |
dc.contributor.author | HODAJ, Enkelejda | |
dc.contributor.author | JAFFUEL, Sylvain | |
dc.contributor.author | LACOMBE, Karine | |
dc.contributor.author | LAINE, Fabrice | |
dc.contributor.author | LEFEBVRE, Maeva | |
dc.contributor.author | MAAKAROUN-VERMESSE, Zoha | |
dc.contributor.author | MAKINSON, Alain | |
dc.contributor.author | PORTEFAIX, Aurelie | |
dc.contributor.author | POURCHER, Valerie | |
dc.contributor.author | REY, David | |
dc.contributor.author | ZUCMAN, David | |
dc.contributor.author | LONGOBARDI, Julie | |
dc.contributor.author | BERTHEAU, Mathilde | |
dc.contributor.author | TARTOUR, Eric | |
dc.contributor.author | DE LAMBALLERIE, Xavier | |
dc.contributor.author | LAUNAY, Odile | |
hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | WITTKOP, Linda | |
dc.date.accessioned | 2024-06-27T13:46:57Z | |
dc.date.available | 2024-06-27T13:46:57Z | |
dc.date.issued | 2024-05-31 | |
dc.identifier.issn | 1878-3511 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/200677 | |
dc.description.abstractEn | BACKGROUND: This study aimed to compare the humoral responses to mRNA COVID-19 vaccination in PWH and HIV-negative individuals. METHODS: We included PWH with an undetectable viral load under ART and HIV-negative participants from the French nationwide ANRS COV-POPART cohort who had received two doses of vaccine as a primary vaccination. We compared humoral response between controls and PWH, stratified by CD4 cell count (< 200/mm(3) and ≥ 200/mm(3) CD4 cell counts) at 1, 6 and 12 months after primary vaccination. RESULTS: A total of 1776 participants were included in this analysis, 684 PWH (99% were on ART, median CD4 counts 673 cells/mm(3)) and 1092 controls. At 1 month, after adjustment on age, sex and BMI, PWH had lower seroneutralization titers than controls and PWH with < 200 CD4 cell/mm3 had lower anti- Spike SARS-CoV-2 IgG antibodies. Same results were found at 6 months. However, in participants who received a booster dose between 6 and 12 months post primary vaccination, we did not observe differences between PWH and controls at 12 months. CONCLUSION: PWH had high responses to primary mRNA COVID-19 vaccination. In those who received a booster dose after six months, the humoral response at 12 months increased to similar levels to controls, even in those with low CD4 counts at baseline. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject.en | COVID-19 | |
dc.subject.en | HIV | |
dc.subject.en | Immunogenicity | |
dc.subject.en | SARS-CoV-2 | |
dc.subject.en | Vaccines | |
dc.title.en | Humoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: a French nationwide multicenter cohort study - ANRS0001s COV-POPART | |
dc.title.alternative | Int J Infect Dis | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1016/j.ijid.2024.107110 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 38825164 | en_US |
bordeaux.journal | International Journal of Infectious Diseases | en_US |
bordeaux.page | 107110 | en_US |
bordeaux.volume | 146 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.institution | INRIA | en_US |
bordeaux.team | SISTM_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Agence Nationale de Recherches sur le Sida et les Hépatites Virales | en_US |
hal.identifier | hal-04627501 | |
hal.version | 1 | |
hal.date.transferred | 2024-06-27T13:47:01Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
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