A joint frailty model for recurrent and competing terminal events: Application to delirium in the ICU
| dc.rights.license | open | en_US |
| dc.contributor.author | ETZKORN, Lacey H | |
| dc.contributor.author | COENT, Quentin Le | |
| dc.contributor.author | VAN DEN BOOGAARD, Mark | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RONDEAU, Virginie
ORCID: 0000-0001-7109-4831 IDREF: 16662988X | |
| dc.contributor.author | COLANTUONI, Elizabeth | |
| dc.date.accessioned | 2024-06-27T13:17:33Z | |
| dc.date.available | 2024-06-27T13:17:33Z | |
| dc.date.issued | 2024-05-30 | |
| dc.identifier.issn | 1097-0258 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/200674 | |
| dc.description.abstractEn | Joint models linking longitudinal biomarkers or recurrent event processes with a terminal event, for example, mortality, have been studied extensively. Motivated by studies of recurrent delirium events in patients receiving care in an intensive care unit (ICU), we devise a joint model for a recurrent event process and multiple terminal events. Being discharged alive from the ICU or experiencing mortality may be associated with a patient's hazard of delirium, violating the assumption of independent censoring. Moreover, the direction of the association between the hazards of delirium and mortality may be opposite of the direction of association between the hazards of delirium and ICU discharge. Hence treating either terminal event as independent censoring may bias inferences. We propose a competing joint model that uses a latent frailty to link a patient's recurrent and competing terminal event processes. We fit our model to data from a completed placebo-controlled clinical trial, which studied whether Haloperidol could prevent death and delirium among ICU patients. The clinical trial served as a foundation for a simulation study, in which we evaluate the properties, for example, bias and confidence interval coverage, of the competing joint model. As part of the simulation study, we demonstrate the shortcomings of using a joint model with a recurrent delirium process and a single terminal event to study delirium in the ICU. Lastly, we discuss limitations and possible extensions for the competing joint model. The competing joint model has been added to frailtypack, an R package for fitting an assortment of joint models. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Competing Events | |
| dc.subject.en | Delirium | |
| dc.subject.en | Frailty | |
| dc.subject.en | Joint Models | |
| dc.subject.en | Recurrent Events | |
| dc.title.en | A joint frailty model for recurrent and competing terminal events: Application to delirium in the ICU | |
| dc.title.alternative | Stat Med | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/sim.10053 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 38564224 | en_US |
| bordeaux.journal | Statistics in Medicine | en_US |
| bordeaux.page | 2389-2402 | en_US |
| bordeaux.volume | 43 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 12 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | BIOSTAT_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | National Institutes of Health | en_US |
| hal.identifier | hal-04627421 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-06-27T13:17:35Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Statistics%20in%20Medicine&rft.date=2024-05-30&rft.volume=43&rft.issue=12&rft.spage=2389-2402&rft.epage=2389-2402&rft.eissn=1097-0258&rft.issn=1097-0258&rft.au=ETZKORN,%20Lacey%20H&COENT,%20Quentin%20Le&VAN%20DEN%20BOOGAARD,%20Mark&RONDEAU,%20Virginie&COLANTUONI,%20Elizabeth&rft.genre=article |
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