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Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorNEUFFER, Jeanne
ORCID: 0000-0002-3667-6948
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWAGNER, Maude
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMORENO, Elisa
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGRAND, Quentin Le
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMISHRA, Aniket
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTREGOUET, David-Alexandre
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST LIMA, Cecile
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorSAMIER FOUBERT, Alexandra
dc.contributor.authorBERR, Claudine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.date.accessioned2024-06-27T11:40:21Z
dc.date.available2024-06-27T11:40:21Z
dc.date.issued2024-06-01
dc.identifier.issn1552-5279en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200672
dc.description.abstractEnINTRODUCTION: Evaluating whether genetic susceptibility modifies the impact of lifestyle-related factors on dementia is critical for prevention. METHODS: We studied 5170 participants from a French cohort of older persons free of dementia at baseline and followed for up to 17 years. The LIfestyle for BRAin health risk score (LIBRA) including 12 modifiable factors was constructed at baseline (higher score indicating greater risk) and was related to both subsequent cognitive decline and dementia incidence, according to genetic susceptibility to dementia (reflected by the apolipoprotein E [APOE] ε4 allele and a genetic risk score [GRS]). RESULTS: The LIBRA was associated with higher dementia incidence, with no significant effect modification by genetics (hazard ratio for one point score = 1.09 [95% confidence interval, 1.05; 1.13]) in APOE ε4 non-carriers and = 1.15 [1.08; 1.22] in carriers; P = 0.15 for interaction). Similar findings were obtained with the GRS and with cognitive decline. DISCUSSION: Lifestyle-based prevention may be effective whatever the genetic susceptibility to dementia.
dc.description.sponsorshipCOGINUT : Cognition, anti-oxydants, acides gras: approche interdisciplinaire du rôle de la nutrition dans le vieillissement du cerveau - ANR-06-PNRA-0005en_US
dc.description.sponsorshipHistoire naturelle du déclin cognitif et du besoin de soins chez le sujet âgéen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enApolipoprotein E
dc.subject.enCognitive Decline
dc.subject.enDementia
dc.subject.enGenetic Risk Score
dc.subject.enModifiable Risk Factors
dc.title.enAssociation of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline
dc.title.alternativeAlzheimers Dementen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.13801en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38775256en_US
bordeaux.journalAlzheimer's & Dementia : the Journal of the Alzheimer's Associationen_US
bordeaux.page4250-4259en_US
bordeaux.volume20en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamACTIVE_BPHen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDSanofien_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDConseil régional de Bourgogne-Franche-Comtéen_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDFondation Plan Alzheimeren_US
bordeaux.identifier.funderIDCaisse nationale de solidarité pour l'autonomieen_US
bordeaux.identifier.funderIDRoche Diagnosticsen_US
hal.identifierhal-04627251
hal.version1
hal.date.transferred2024-06-27T11:40:25Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20&%20Dementia%20:%20the%20Journal%20of%20the%20Alzheimer's%20Association&rft.date=2024-06-01&rft.volume=20&rft.issue=6&rft.spage=4250-4259&rft.epage=4250-4259&rft.eissn=1552-5279&rft.issn=1552-5279&rft.au=NEUFFER,%20Jeanne&WAGNER,%20Maude&MORENO,%20Elisa&GRAND,%20Quentin%20Le&MISHRA,%20Aniket&rft.genre=article


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