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Genetic variants for head size share genes and pathways with cancer

dc.rights.licenseopenen_US
dc.contributor.authorKNOL, Maria J
dc.contributor.authorPOOT, Raymond A
dc.contributor.authorEVANS, Tavia E
dc.contributor.authorSATIZABAL, Claudia L
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMISHRA, Aniket
dc.contributor.authorSARGURUPREMRAJ, Muralidharan
dc.contributor.authorVAN DER AUWERA, Sandra
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUPERRON, Marie-Gabrielle
dc.contributor.authorJIAN, Xueqiu
dc.contributor.authorHOSTETTLER, Isabel C
dc.contributor.authorVAN DAM-NOLEN, Dianne H K
dc.contributor.authorLAMBALLAIS, Sander
dc.contributor.authorPAWLAK, Mikolaj A
dc.contributor.authorLEWIS, Cora E
dc.contributor.authorCARRION-CASTILLO, Amaia
dc.contributor.authorVAN ERP, Theo G M
dc.contributor.authorREINBOLD, Celine S
dc.contributor.authorSHIN, Jean
dc.contributor.authorSCHOLZ, Markus
dc.contributor.authorHABERG, Asta K
dc.contributor.authorKAMPE, Anders
dc.contributor.authorLI, Gloria H Y
dc.contributor.authorAVINUN, Reut
dc.contributor.authorATKINS, Joshua R
dc.contributor.authorHSU, Fang-Chi
dc.contributor.authorAMOD, Alyssa R
dc.contributor.authorLAM, Max
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTSUCHIDA, Ami
dc.contributor.authorTEUNISSEN, Mariel W A
dc.contributor.authorAYGUN, Nil
dc.contributor.authorPATEL, Yash
dc.contributor.authorLIANG, Dan
dc.contributor.authorBEISER, Alexa S
dc.contributor.authorBEYER, Frauke
dc.contributor.authorBIS, Joshua C
dc.contributor.authorBOS, Daniel
dc.contributor.authorBRYAN, R Nick
dc.contributor.authorBULOW, Robin
dc.contributor.authorCASPERS, Svenja
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCATHELINE, Gwenaelle
dc.contributor.authorCECIL, Charlotte A M
dc.contributor.authorDALVIE, Shareefa
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
dc.contributor.authorDECARLI, Charles
dc.contributor.authorENLUND-CERULLO, Maria
dc.contributor.authorFORD, Judith M
dc.contributor.authorFRANKE, Barbara
dc.contributor.authorFREEDMAN, Barry I
dc.contributor.authorFRIEDRICH, Nele
dc.contributor.authorGREEN, Melissa J
dc.contributor.authorHAWORTH, Simon
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorHOFFMANN, Per
dc.contributor.authorHOMUTH, Georg
dc.contributor.authorIKRAM, M Kamran
dc.contributor.authorJACK, Clifford R
dc.contributor.authorJAHANSHAD, Neda
dc.contributor.authorJOCKWITZ, Christiane
dc.contributor.authorKAMATANI, Yoichiro
dc.contributor.authorKNODT, Annchen R
dc.contributor.authorLI, Shuo
dc.contributor.authorLIM, Keane
dc.contributor.authorLONGSTRETH, W T
dc.contributor.authorMACCIARDI, Fabio
dc.contributor.authorMAKITIE, Outi
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorMAZOYER, Bernard
dc.contributor.authorMEDLAND, Sarah E
dc.contributor.authorMIYAMOTO, Susumu
dc.contributor.authorMOEBUS, Susanne
dc.contributor.authorMOSLEY, Thomas H
dc.contributor.authorMUETZEL, Ryan
dc.contributor.authorMUHLEISEN, Thomas W
dc.contributor.authorNAGATA, Manabu
dc.contributor.authorNAKAHARA, Soichiro
dc.contributor.authorPALMER, Nicholette D
dc.contributor.authorPAUSOVA, Zdenka
dc.contributor.authorPREDA, Adrian
dc.contributor.authorQUIDE, Yann
dc.contributor.authorREAY, William R
dc.contributor.authorROSHCHUPKIN, Gennady V
dc.contributor.authorSCHMIDT, Reinhold
dc.contributor.authorSCHREINER, Pamela J
dc.contributor.authorSETOH, Kazuya
dc.contributor.authorSHAPLAND, Chin Yang
dc.contributor.authorSIDNEY, Stephen
dc.contributor.authorST POURCAIN, Beate
dc.contributor.authorSTEIN, Jason L
dc.contributor.authorTABARA, Yasuharu
dc.contributor.authorTEUMER, Alexander
dc.contributor.authorUHLMANN, Anne
dc.contributor.authorVAN DER LUGT, Aad
dc.contributor.authorVERNOOIJ, Meike W
dc.contributor.authorWERRING, David J
dc.contributor.authorWINDHAM, B Gwen
dc.contributor.authorWITTE, A Veronica
dc.contributor.authorWITTFELD, Katharina
dc.contributor.authorYANG, Qiong
dc.contributor.authorYOSHIDA, Kazumichi
dc.contributor.authorBRUNNER, Han G
dc.contributor.authorLE GRAND, Quentin
dc.contributor.authorSIM, Kang
dc.contributor.authorSTEIN, Dan J
dc.contributor.authorBOWDEN, Donald W
dc.contributor.authorCAIRNS, Murray J
dc.contributor.authorHARIRI, Ahmad R
dc.contributor.authorCHEUNG, Ching-Lung
dc.contributor.authorANDERSSON, Sture
dc.contributor.authorVILLRINGER, Arno
dc.contributor.authorPAUS, Tomas
dc.contributor.authorCICHON, Sven
dc.contributor.authorCALHOUN, Vince D
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorCRIVELLO, Fabrice
dc.contributor.authorLAUNER, Lenore J
dc.contributor.authorWHITE, Tonya
dc.contributor.authorKOUDSTAAL, Peter J
dc.contributor.authorHOULDEN, Henry
dc.contributor.authorFORNAGE, Myriam
dc.contributor.authorMATSUDA, Fumihiko
dc.contributor.authorGRABE, Hans J
dc.contributor.authorIKRAM, M Arfan
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorTHOMPSON, Paul M
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorADAMS, Hieab H H
dc.date.accessioned2024-06-27T09:40:35Z
dc.date.available2024-06-27T09:40:35Z
dc.date.issued2024-05-21
dc.identifier.issn2666-3791en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200671
dc.description.abstractEnThe size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants. Head size variants are also near genes preferentially expressed in intermediate progenitor cells, neural cells linked to evolutionary brain expansion. Our results indicate that genes regulating early brain and cranial growth incline to neoplasia later in life, irrespective of height. This warrants investigation of clinical implications of the link between head size and cancer.
dc.description.sponsorshipCOGINUT : Cognition, anti-oxydants, acides gras: approche interdisciplinaire du rôle de la nutrition dans le vieillissement du cerveau - ANR-06-PNRA-0005en_US
dc.description.sponsorshipStopping cognitive decline and dementia by fighting covert cerebral small vessel diseaseen_US
dc.description.sponsorshipVaincre les maladies vasculaires cérébrales par un nouveau paradigme de prévention de précision et d'innovation thérapeutiqueen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCancer
dc.subject.enGenetics
dc.subject.enGenome-Wide Association Study
dc.subject.enHead Circumference
dc.subject.enHead Size
dc.subject.enIntracranial Volume
dc.subject.enMeta-Analysis
dc.title.enGenetic variants for head size share genes and pathways with cancer
dc.title.alternativeCell Rep Med
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.xcrm.2024.101529en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38703765en_US
bordeaux.journalCell Reports Medicineen_US
bordeaux.page101529en_US
bordeaux.volume5en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamACTIVE_BPHen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.identifier.funderIDFondation Plan Alzheimeren_US
bordeaux.identifier.funderIDCaisse nationale de solidarité pour l'autonomieen_US
hal.identifierhal-04627076
hal.version2
hal.date.transferred2024-06-27T23:04:17Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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