Three-dimensional cardiac magnetic resonance allows the identification of slow-conducting anatomical isthmuses in tetralogy of Fallot
| dc.rights.license | open | en_US |
| dc.contributor.author | KIMURA, Yoshitaka | |
| dc.contributor.author | WALLET, Justin | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BOUYER, Benjamin | |
| dc.contributor.author | JONGBLOED, Monique R M | |
| dc.contributor.author | BERTELS, Robin | |
| dc.contributor.author | HAZEKAMP, Mark G | |
| dc.contributor.author | THAMBO, Jean-Benoit | |
| dc.contributor.author | IRIART, Xavier | |
| dc.contributor.author | COCHET, Hubert | |
| dc.contributor.author | SACHER, Frederic | |
| dc.contributor.author | LAMB, Hildo J | |
| dc.contributor.author | BLOM, Nico A | |
| dc.contributor.author | ZEPPENFELD, Katja | |
| dc.date.accessioned | 2024-06-27T08:05:17Z | |
| dc.date.available | 2024-06-27T08:05:17Z | |
| dc.date.issued | 2024-05-14 | |
| dc.identifier.issn | 1522-9645 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/200666 | |
| dc.description.abstractEn | BACKGROUND AND AIMS: Patients with repaired tetralogy of Fallot remain at risk of life-threatening ventricular tachycardia related to slow-conducting anatomical isthmuses (SCAIs). Preventive ablation of SCAI identified by invasive electroanatomical mapping is increasingly performed. This study aimed to non-invasively identify SCAI using 3D late gadolinium enhancement cardiac magnetic resonance (3D-LGE-CMR). METHODS: Consecutive tetralogy of Fallot patients who underwent right ventricular electroanatomical mapping (RV-EAM) and 3D-LGE-CMR were included. High signal intensity threshold for abnormal myocardium was determined based on direct comparison of bipolar voltages and signal intensity by co-registration of RV-EAM with 3D-LGE-CMR. The diagnostic performance of 3D-LGE-CMR to non-invasively identify SCAI was determined, validated in a second cohort, and compared with the discriminative ability of proposed risk scores. RESULTS: The derivation cohort consisted of 48 (34 ± 16 years) and the validation cohort of 53 patients (36 ± 18 years). In the derivation cohort, 78 of 107 anatomical isthmuses (AIs) identified by EAM were normal-conducting AI, 22 were SCAI, and 7 blocked AI. High signal intensity threshold was 42% of the maximal signal intensity. The sensitivity and specificity of 3D-LGE-CMR for identifying SCAI or blocked AI were 100% and 90%, respectively. In the validation cohort, 85 of 124 AIs were normal-conducting AI, 36 were SCAI, and 3 blocked AI. The sensitivity and specificity of 3D-LGE-CMR were 95% and 91%, respectively. All risk scores showed an at best modest performance to identify SCAI (area under the curve ≤ .68). CONCLUSIONS: 3D late gadolinium enhancement cardiac magnetic resonance can identify SCAI with excellent accuracy and may refine non-invasive risk stratification and patient selection for invasive EAM in tetralogy of Fallot. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Anatomical isthmus | |
| dc.subject.en | Cardiac magnetic resonance | |
| dc.subject.en | Risk stratification | |
| dc.subject.en | Tetralogy of Fallot | |
| dc.subject.en | Ventricular tachycardia | |
| dc.title.en | Three-dimensional cardiac magnetic resonance allows the identification of slow-conducting anatomical isthmuses in tetralogy of Fallot | |
| dc.title.alternative | Eur Heart J | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/eurheartj/ehae268 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 38748258 | en_US |
| bordeaux.journal | European Heart Journal | en_US |
| bordeaux.page | 2079-2094 | en_US |
| bordeaux.volume | 45 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 23 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | AHEAD_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04626735 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-06-27T08:05:20Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Heart%20Journal&rft.date=2024-05-14&rft.volume=45&rft.issue=23&rft.spage=2079-2094&rft.epage=2079-2094&rft.eissn=1522-9645&rft.issn=1522-9645&rft.au=KIMURA,%20Yoshitaka&WALLET,%20Justin&BOUYER,%20Benjamin&JONGBLOED,%20Monique%20R%20M&BERTELS,%20Robin&rft.genre=article |
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