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Maternal immune activation during pregnancy is associated with more difficulties in socio-adaptive behaviors in autism spectrum disorder

dc.rights.licenseopenen_US
dc.contributor.authorELLUL, Pierre
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMARUANI, Anna
dc.contributor.authorVANTALON, Valerie
dc.contributor.authorHUMEAU, Elise
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorAMESTOY, Anouck
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorANCHORDOQUI, Andrea
dc.contributor.authorATZORI, Paola
dc.contributor.authorBALEYTE, Jean-Marc
dc.contributor.authorBENMANSOUR, Safiyah
dc.contributor.authorBONNOT, Olivier
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorBOUVARD, Manuel
dc.contributor.authorCARTIGNY, Ariane
dc.contributor.authorCOULON, Nathalie
dc.contributor.authorCOUTELLE, Romain
dc.contributor.authorDA FONSECA, David
dc.contributor.authorDEMILY, Caroline
dc.contributor.authorGIVAUDAN, Marion
dc.contributor.authorGOLLIER-BRIANT, Fanny
dc.contributor.authorGUENOLE, Fabian
dc.contributor.authorKOCH, Andrea
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorLEFEBVRE, Aline
dc.contributor.authorLEJUSTE, Florian
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorLEVY, Charlotte
dc.contributor.authorMENDES, Eugenie
dc.contributor.authorROBERT, Natalia
dc.contributor.authorSCHRODER, Carmen M
dc.contributor.authorSPERANZA, Mario
dc.contributor.authorZANTE, Elodie
dc.contributor.authorPEYRE, Hugo
dc.contributor.authorKLATZMANN, David
dc.contributor.authorTCHITCHEK, Nicolas
dc.contributor.authorDELORME, Richard
dc.date.accessioned2024-06-07T13:40:08Z
dc.date.available2024-06-07T13:40:08Z
dc.date.issued2023-10-17
dc.identifier.issn2045-2322en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200344
dc.description.abstractEnAutism spectrum disorder (ASD) are neurodevelopmental conditions characterised by deficits in social communication and interaction and repetitive behaviours. Maternal immune activation (MIA) during the mid-pregnancy is a known risk factor for ASD. Although reported in 15% of affected individuals, little is known about the specificity of their clinical profiles. Adaptive skills represent a holistic approach to a person's competencies and reflect specifically in ASD, their strengths and difficulties. In this study, we hypothesised that ASD individual with a history of MIA (MIA+) could be more severely socio-adaptively impaired than those without MIA during pregnancy (MIA-). To answer this question, we considered two independent cohorts of individuals with ASD (PARIS study and FACE ASD) screened for pregnancy history, and used supervised and unsupervised machine learning algorithms. We included 295 mother–child dyads with 14% of them with MIA+. We found that ASD-MIA+ individuals displayed more severe maladaptive behaviors, specifically in their socialization abilities. MIA+ directly influenced individual's socio-adaptive skills, independent of other covariates, including ASD severity. Interestingly, MIA+ affect persistently the socio-adaptive behavioral trajectories of individuals with ASD. The current study has a retrospective design with possible recall bias regarding the MIA event and, even if pooled from two cohorts, has a relatively small population. In addition, we were limited by the number of covariables available potentially impacted socio-adaptive behaviors. Larger prospective study with additional dimensions related to ASD is needed to confirm our results. Specific pathophysiological pathways may explain these clinical peculiarities of ASD- MIA+ individuals, and may open the way to new perspectives in deciphering the phenotypic complexity of ASD and for the development of specific immunomodulatory strategies. © 2023, Springer Nature Limited.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAdaptation
dc.subject.enPsychological
dc.subject.enAutism Spectrum Disorder*
dc.subject.enFemale
dc.subject.enHumans
dc.subject.enPregnancy
dc.subject.enPrenatal Exposure Delayed Effects*
dc.subject.enProspective Studies
dc.subject.enRetrospective Studies
dc.title.enMaternal immune activation during pregnancy is associated with more difficulties in socio-adaptive behaviors in autism spectrum disorder
dc.title.alternativeSci Repen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41598-023-45060-zen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed37848536en_US
bordeaux.journalScientific Reportsen_US
bordeaux.page17687en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.identifierhal-04605111
hal.version1
hal.date.transferred2024-06-07T13:40:12Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BYen_US
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