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Proof of concept of intracochlear drug administration by laser-assisted bioprinting in mice

dc.rights.licenseopenen_US
dc.contributor.authorJAFFREDO, M.
dc.contributor.authorDUCHAMP, O.
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorTOUYA, N.
dc.contributor.authorBOULEAU, Y.
dc.contributor.authorDULON, D.
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorDEVILLARD, R.
dc.contributor.authorBONNARD, D.
dc.date.accessioned2024-06-06T06:52:08Z
dc.date.available2024-06-06T06:52:08Z
dc.date.issued2023
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200290
dc.description.abstractEnTranstympanic administration is used clinically for the injection of gentamicin and/or corticosteroids. This atraumatic route is based on passive diffusion through the round window membrane (RWM). The main limitation of this method is related to the clearance through the Eustachian tube, making the concentration of the therapeutic agent at the intracochlear level uncertain and limited. Moreover, this technique remains unsuitable for molecules of high molecular weight or in the case of gene therapies. The purpose was to study a new technique of intracochlear administration in an atraumatic, direct and controlled manner by laser-assisted bioprinting (LAB). LAB was used to deliver dexamethasone phosphate with thermosensitive hydrogel on the mouse RWM. After validation of the regularity and homogeneity of the pattern, the diffusion in vivo of the dexamethasone into the perilymph after LAB has been confirmed by ELISA. Auditory function measurements showed no hearing impairment suggesting that bioprinting does not induce significant cochlear damage. Hence, the present proof of concept study introduces a promising approach for inner ear drug delivery. © 2023 Elsevier B.V.
dc.language.isoENen_US
dc.title.enProof of concept of intracochlear drug administration by laser-assisted bioprinting in mice
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.heares.2023.108880en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalHearing Researchen_US
bordeaux.volume438en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04602867
hal.version1
hal.date.transferred2024-06-06T06:52:11Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Hearing%20Research&rft.date=2023&rft.volume=438&rft.au=JAFFREDO,%20M.&DUCHAMP,%20O.&TOUYA,%20N.&BOULEAU,%20Y.&DULON,%20D.&rft.genre=article


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