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Impact of drug consumption rooms on non-fatal overdoses, abscesses and emergency department visits in people who inject drugs in France: results from the COSINUS cohort

dc.rights.licenseopenen_US
hal.structure.identifierSciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
hal.structure.identifierInstitut des sciences de la santé publique [Marseille] [ISSPAM]
dc.contributor.authorROUX, P
hal.structure.identifierCERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société [CERMES3 - UMR 8211 / U988 / UM 7]
hal.structure.identifierBritish Columbia
dc.contributor.authorJAUFFRET-ROUSTIDE, M
hal.structure.identifierSciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
hal.structure.identifierInstitut des sciences de la santé publique [Marseille] [ISSPAM]
dc.contributor.authorDONADILLE, C
hal.structure.identifierSciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
hal.structure.identifierInstitut des sciences de la santé publique [Marseille] [ISSPAM]
dc.contributor.authorBRIAND MADRID, L
hal.structure.identifierUniversity of Pennsylvania
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
hal.structure.identifierCentre hospitalier Charles Perrens [Bordeaux]
dc.contributor.authorDENIS, C
hal.structure.identifierObservatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] [ORS PACA]
dc.contributor.authorCÉLÉRIER, I
hal.structure.identifierCERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société [CERMES3 - UMR 8211 / U988 / UM 7]
dc.contributor.authorCHAUVIN, C
hal.structure.identifierNeuropsychologie Cognitive et Physiopathologie de la Schizophrénie [NCPS]
dc.contributor.authorHAMELIN, N
hal.structure.identifierObservatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] [ORS PACA]
dc.contributor.authorMARADAN, G
hal.structure.identifierSciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
hal.structure.identifierInstitut des sciences de la santé publique [Marseille] [ISSPAM]
dc.contributor.authorCARRIERI, M
hal.structure.identifierSciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
hal.structure.identifierInstitut des sciences de la santé publique [Marseille] [ISSPAM]
dc.contributor.authorPROTOPOPESCU, C
hal.structure.identifierNeuropsychologie Cognitive et Physiopathologie de la Schizophrénie [NCPS]
hal.structure.identifierFédération de Médecine Translationnelle de Strasbourg [FMTS]
dc.contributor.authorLALANNE, L
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorAURIACOMBE, Marc
dc.date.accessioned2024-06-05T07:33:45Z
dc.date.available2024-06-05T07:33:45Z
dc.date.issued2023-04-19
dc.identifier.issn0300-5771en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200276
dc.description.abstractEnBackground: The effectiveness of drug consumption rooms (DCRs) for people who inject drugs (PWID) has been demonstrated for HIV and hepatitis C virus risk practices, and access to care for substance use disorders. However, data on other health-related complications are scarce. Using data from the French COSINUS cohort, we investigated the impact of DCR exposure on non-fatal overdoses, abscesses and emergency department (ED) visits, all in the previous 6 months.Methods: COSINUS is a 12-month prospective cohort study of 665 PWID in France studying DCR effectiveness on health. We collected data from face-to-face interviews at enrolment, and at 6 and 12 months of follow-up. After adjusting for other correlates (P-value < 0.05), the impact of DCR exposure on each outcome was assessed using a two-step Heckman mixed-effects probit model, allowing us to adjust for potential non-randomization bias due to differences between DCR-exposed and DCR-unexposed participants, while taking into account the correlation between repeated measures.Results: At enrolment, 21%, 6% and 38% of the 665 participants reported overdoses, abscesses and ED visits, respectively. Multivariable models found that DCR-exposed participants were less likely to report overdoses [adjusted coefficient (95% CI): -0.47 (-0.88; -0.07), P = 0.023], abscesses [-0.74 (-1.11; -0.37), P < 0.001] and ED visits [-0.74 (-1.27; -0.20), P = 0.007].Conclusion: This is the first study to show the positive impact of DCR exposure on abscesses and ED visits, and confirms DCR effectiveness in reducing overdoses, when adjusting for potential non-randomization bias. Our findings strengthen the argument to expand DCR implementation to improve PWID injection environment and health.
dc.language.isoENen_US
dc.subject.enSafer injecting facility
dc.subject.eninjection drug users
dc.subject.enrisk environment
dc.subject.enabscess
dc.subject.enoverdose
dc.subject.enemergency department
dc.subject.enskin and soft tissue infections
dc.title.enImpact of drug consumption rooms on non-fatal overdoses, abscesses and emergency department visits in people who inject drugs in France: results from the COSINUS cohort
dc.title.alternativeInt J Epidemiolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ije/dyac120en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35690956en_US
bordeaux.journalInternational Journal of Epidemiologyen_US
bordeaux.page562 - 576en_US
bordeaux.volume52en_US
bordeaux.hal.laboratoriesSANPSY (Sommeil, Addiction, Neuropsychiatrie) - UMR 6033en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierinserm-04312540
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=International%20Journal%20of%20Epidemiology&amp;rft.date=2023-04-19&amp;rft.volume=52&amp;rft.issue=2&amp;rft.spage=562%20-%20576&amp;rft.epage=562%20-%20576&amp;rft.eissn=0300-5771&amp;rft.issn=0300-5771&amp;rft.au=ROUX,%20P&amp;JAUFFRET-ROUSTIDE,%20M&amp;DONADILLE,%20C&amp;BRIAND%20MADRID,%20L&amp;DENIS,%20C&amp;rft.genre=article


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