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Development of Novel Polysaccharide Membranes for Guided Bone Regeneration: In Vitro and In Vivo Evaluations

dc.rights.licenseopenen_US
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorAHMED OMAR, Naïma
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorROQUE, Jéssica
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorGALVEZ, Paul
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSIADOUS, Robin
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCHASSANDE, Olivier
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCATROS, Sylvain
dc.contributor.authorROQUES, Samantha
dc.contributor.authorDURAND, Marlène
dc.contributor.authorBERGEAUT, Céline
dc.contributor.authorBIDAULT, Laurent
dc.contributor.authorAPRILE, Paola
dc.contributor.authorLETOURNEUR, Didier
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorFRICAIN, Jean-Christophe
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorFENELON, Mathilde
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorAMEDEE, Joelle
ORCID: 0000-0002-4888-0129
IDREF: 87485605
dc.date.accessioned2024-06-03T14:19:14Z
dc.date.available2024-06-03T14:19:14Z
dc.date.issued2023-11
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200230
dc.description.abstractEnIntroduction: Guided bone regeneration (GBR) procedures require selecting suitable membranes for oral surgery. Pullulan and/or dextran-based polysaccharide materials have shown encouraging results in bone regeneration as bone substitutes but have not been used to produce barrier membranes. The present study aimed to develop and characterize pullulan/dextran-derived membranes for GBR. Materials and methods: Two pullulan/dextran-based membranes, containing or not hydroxyapatite (HA) particles, were developed. In vitro, cytotoxicity evaluation was performed using human bone marrow mesenchymal stem cells (hBMSCs). Biocompatibility was assessed on rats in a subcutaneous model for up to 16 weeks. In vivo, rat femoral defects were created on 36 rats to compare the two pullulan/dextran-based membranes with a commercial collagen membrane (Bio-Gide®). Bone repair was assessed radiologically and histologically. Results: Both polysaccharide membranes demonstrated cytocompatibility and biocompatibility. Micro-computed tomography (micro-CT) analyses at two weeks revealed that the HA-containing membrane promoted a significant increase in bone formation compared to Bio-Gide®. At one month, similar effects were observed among the three membranes in terms of bone regeneration. Conclusion: The developed pullulan/dextran-based membranes evidenced biocompatibility without interfering with bone regeneration and maturation. The HA-containing membrane, which facilitated early bone regeneration and offered adequate mechanical support, showed promising potential for GBR procedures. © 2023 by the authors.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enDevelopment of Novel Polysaccharide Membranes for Guided Bone Regeneration: In Vitro and In Vivo Evaluations
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/bioengineering10111257en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalBioengineeringen_US
bordeaux.page1257en_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Bioengineering&rft.date=2023-11&rft.volume=10&rft.issue=11&rft.spage=1257&rft.epage=1257&rft.au=AHMED%20OMAR,%20Na%C3%AFma&ROQUE,%20J%C3%A9ssica&GALVEZ,%20Paul&SIADOUS,%20Robin&CHASSANDE,%20Olivier&rft.genre=article


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