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Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults

dc.rights.licenseopenen_US
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
dc.contributor.authorHE, Lingxiao
hal.structure.identifierSaint Louis University [SLU]
dc.contributor.authorMORLEY, John
hal.structure.identifierSaint Louis University [SLU]
dc.contributor.authorAGGARWAL, Geetika
hal.structure.identifierSaint Louis University [SLU]
dc.contributor.authorNGUYEN, Andrew
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorVELLAS, Bruno
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorDE SOUTO BARRETO, Philipe
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorGUYONNET, Sophie
dc.contributor.authorCARRIÉ, Isabelle
dc.contributor.authorBRIGITTE, Lauréane
dc.contributor.authorFAISANT, Catherine
dc.contributor.authorLALA, Françoise
dc.contributor.authorDELRIEU, Julien
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorVILLARS, Hélène
dc.contributor.authorCOMBROUZE, Emeline
dc.contributor.authorBADUFLE, Carole
dc.contributor.authorZUERAS, Audrey
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorANDRIEU, Sandrine
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorCANTET, Christelle
dc.contributor.authorMORIN, Christophe
dc.contributor.authorVAN KAN, Gabor Abellan
dc.contributor.authorDUPUY, Charlotte
dc.contributor.authorROLLAND, Yves
dc.contributor.authorCAILLAUD, Céline
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorOUSSET, Pierre-Jean
dc.contributor.authorWILLIS, Sherry
dc.contributor.authorBELLEVILLE, Sylvie
dc.contributor.authorGILBERT, Brigitte
dc.contributor.authorFONTAINE, Francine
dc.contributor.authorDARTIGUES, Jean-François
dc.contributor.authorMARCET, Isabelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELVA, Fleur
dc.contributor.authorFOUBERT, Alexandra
dc.contributor.authorCERDA, Sandrine
dc.contributor.authorNOËLLE-CUFFI, Marie
dc.contributor.authorCOSTES, Corinne
dc.contributor.authorROUAUD, Olivier
dc.contributor.authorMANCKOUNDIA, Patrick
dc.contributor.authorQUIPOURT, Valérie
dc.contributor.authorMARILIER, Sophie
dc.contributor.authorFRANON, Evelyne
dc.contributor.authorBORIES, Lawrence
dc.contributor.authorPADER, Marie-Laure
dc.contributor.authorBASSET, Marie-France
dc.contributor.authorLAPOUJADE, Bruno
dc.contributor.authorFAURE, Valérie
dc.contributor.authorTONG, Michael Li Yung
dc.contributor.authorMALICK-LOISEAU, Christine
dc.contributor.authorCAZABAN-CAMPISTRON, Evelyne
dc.contributor.authorDESCLAUX, Françoise
dc.contributor.authorBLATGE, Colette
dc.contributor.authorDANTOINE, Thierry
dc.contributor.authorLAUBARIE-MOURET, Cécile
dc.contributor.authorSAULNIER, Isabelle
dc.contributor.authorCLÉMENT, Jean-Pierre
dc.contributor.authorPICAT, Marie-Agnès
dc.contributor.authorBERNARD-BOURZEIX, Laurence
dc.contributor.authorWILLEBOIS, Stéphanie
dc.contributor.authorDÉSORMAIS, Iléana
dc.contributor.authorCARDINAUD, Noëlle
dc.contributor.authorBONNEFOY, Marc
dc.contributor.authorLIVET, Pierre
dc.contributor.authorREBAUDET, Pascale
dc.contributor.authorGÉDÉON, Claire
dc.contributor.authorBURDET, Catherine
dc.contributor.authorTERRACOL, Flavien
dc.contributor.authorPESCE, Alain
dc.contributor.authorROTH, Stéphanie
dc.contributor.authorCHAILLOU, Sylvie
dc.contributor.authorLOUCHART, Sandrine
dc.contributor.authorSUDRES, Kristel
dc.contributor.authorLEBRUN, Nicolas
dc.contributor.authorBARRO-BELAYGUES, Nadège
dc.contributor.authorTOUCHON, Jacques
dc.contributor.authorBENNYS, Karim
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
hal.structure.identifierInstitut des Neurosciences de Montpellier [INM]
dc.contributor.authorGABELLE, Audrey
dc.contributor.authorROMANO, Aurélia
dc.contributor.authorTOUATI, Lynda
dc.contributor.authorMARELLI, Cécilia
dc.contributor.authorPAYS, Cécile
dc.contributor.authorROBERT, Philippe
dc.contributor.authorLE DUFF, Franck
dc.contributor.authorGERVAIS, Claire
dc.contributor.authorGONFRIER, Sébastien
dc.contributor.authorGASNIER, Yannick
dc.contributor.authorBORDES, Serge
dc.contributor.authorBEGORRE, Danièle
dc.contributor.authorCARPUAT, Christian
dc.contributor.authorKHALES, Khaled
dc.contributor.authorLEFEBVRE, Jean-François
dc.contributor.authorIDRISSI, Samira Misbah El
dc.contributor.authorSKOLIL, Pierre
dc.contributor.authorSALLES, Jean-Pierre
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorLEHÉRICY, Stéphane
dc.contributor.authorCHUPIN, Marie
dc.contributor.authorMANGIN, Jean-François
dc.contributor.authorBOUHAYIA, Ali
dc.contributor.authorALLARD, Michèle
dc.contributor.authorRICOLFI, Frédéric
dc.contributor.authorDUBOIS, Dominique
dc.contributor.authorMARTEL, Marie Paule Bonceour
dc.contributor.authorCOTTON, François
dc.contributor.authorBONAFÉ, Alain
dc.contributor.authorCHANALET, Stéphane
dc.contributor.authorHUGON, Françoise
dc.contributor.authorBONNEVILLE, Fabrice
dc.contributor.authorCOGNARD, Christophe
dc.contributor.authorCHOLLET, François
dc.contributor.authorPAYOUX, Pierre
dc.contributor.authorVOISIN, Thierry
dc.contributor.authorPEIFFER, Sophie
dc.contributor.authorHITZEL, Anne
dc.contributor.authorZANCA, Michel
dc.contributor.authorMONTEIL, Jacques
dc.contributor.authorDARCOURT, Jacques
dc.contributor.authorMOLINIER, Laurent
dc.contributor.authorDERUMEAUX, Hélène
dc.contributor.authorCOSTA, Nadège
dc.contributor.authorPERRET, Bertrand
dc.contributor.authorVINEL, Claire
dc.contributor.authorCASPAR-BAUGUIL, Sylvie
dc.contributor.authorOLIVIER-ABBAL, Pascale
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorCOLEY, Nicola
dc.date.accessioned2024-05-29T07:53:14Z
dc.date.available2024-05-29T07:53:14Z
dc.date.issued2021-12-01
dc.identifier.issn2045-2322en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200114
dc.description.abstractEnNeurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and cognitive decline in older adults are still limited. 504 older adults (median age 75 years) who expressed memory complaints were selected from the Multidomain Alzheimer’s Preventive Trial (MAPT) and were classified as normal cognition (NC) or mild cognitive impairment (MCI). Cognitive functions were measured as mini mental state examination (MMSE) and composite cognitive score (CCS) over a 4-year period. Plasma NfL was measured at the first or the second year of the MAPT. Mixed-effects linear models were performed to evaluate cross-sectional and longitudinal associations. In the whole population, higher plasma NfL was cross-sectionally associated with lower cognitive functions (MMSE: β = − 0.007, 95% CI [− 0.013, − 0.001]; CCS: β = − 0.003, 95% CI [− 0.006, − 0.001]). In adults with MCI, but not NC, higher plasma NfL was associated with lower CCS at the cross-sectional level (β = − 0.003, 95% CI [− 0.005, − 0.0002]). The upper quartile NfL group further demonstrated more over time decline in CCS (β = − 0.07, 95% CI [− 0.12, − 0.01]) under the MCI status. Plasma NfL can be a promising biomarker of progressive cognition decline in older adults with MCI.
dc.language.isoENen_US
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshIntermediate Filaments
dc.subject.meshMale
dc.subject.meshMental Status and Dementia Tests
dc.subject.meshNeurofilament Proteins
dc.subject.meshAlzheimer Disease
dc.subject.meshAmyloid beta-Peptides
dc.subject.meshBiomarkers
dc.subject.meshCognition
dc.subject.meshCognitive Dysfunction
dc.subject.meshCross-Sectional Studies
dc.subject.meshFemale
dc.subject.meshHumans
dc.title.enPlasma neurofilament light chain is associated with cognitive decline in non-dementia older adults
dc.title.alternativeSci Repen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41598-021-91038-0en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34183688en_US
bordeaux.journalScientific Reportsen_US
bordeaux.page13394en_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-03649025
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2021-12-01&rft.volume=11&rft.issue=1&rft.spage=13394&rft.epage=13394&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=HE,%20Lingxiao&MORLEY,%20John&AGGARWAL,%20Geetika&NGUYEN,%20Andrew&VELLAS,%20Bruno&rft.genre=article


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