Multivalent and multifunctional polysaccharide-based particles for controlled receptor recognition
dc.rights.license | open | |
hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | DUAN, Haohao | |
hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
dc.contributor.author | DONOVAN, Mark | |
hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
dc.contributor.author | FOUCHER, Aude | |
hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
dc.contributor.author | SCHULTZE, Xavier | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20003 | |
dc.description.abstractEn | Polysaccharides represent a versatile class of building blocks that are used in macromolecular design. By choosing the appropriate saccharide block, various physico-chemical and biological properties can be introduced both at the level of the polymer chains and the resulting self-assembled nanostructures. Here, we synthetized amphiphilic diblock copolymers combining a hydrophobic and helical poly(γ-benzyl-L-glutamate) PBLG and two polysaccharides, namely hyaluronic acid (HA) and laminarin (LAM). The copolymers could self-assemble to form particles in water by nanoprecipitation. In addition, hybrid particles containing both HA and LAM in different ratios were obtained by co-nanoprecipitation of the two copolymers. By controlling the self-assembly process, five particle samples with different morphologies and compositions were developed. The interaction between the particles and biologically relevant proteins for HA and LAM, namely CD44 and Dectin-1 respectively, was evaluated by surface plasmon resonance (SPR). We demonstrated that the particle-protein interaction could be modulated by the particle structure and composition. It is therefore suggested that this method based on nanoprecipitation is a practical and versatile way to obtain particles with controllable interactions with proteins, hence with the appropriate biological properties for biomedical applications such as drug delivery. | |
dc.language.iso | en | |
dc.publisher | Nature Publishing Group | |
dc.rights.uri | http://creativecommons.org/licenses/by/ | |
dc.title.en | Multivalent and multifunctional polysaccharide-based particles for controlled receptor recognition | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1038/s41598-018-32994-y | |
dc.subject.hal | Chimie/Polymères | |
dc.subject.hal | Chimie/Chimie thérapeutique | |
bordeaux.journal | Scientific Reports | |
bordeaux.page | 14730 | |
bordeaux.volume | 8 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.issue | 1 | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01893210 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01893210v1 | |
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