Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy
dc.rights.license | open | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | SANSON, Charles | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | DIOU, Odile | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | THEVENOT, Julie | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | IBARBOURE, Emmanuel | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 1 LCPO : Polymerization Catalyses & Engineering | |
dc.contributor.author | SOUM, Alain | |
hal.structure.identifier | Laboratoire Léon Brillouin [LLB - UMR 12] | |
dc.contributor.author | BRÛLET, Annie | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | MIRAUX, Sylvain | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | THIAUDIÈRE, Eric | |
hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
dc.contributor.author | TAN, Sisareuth | |
hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
dc.contributor.author | BRISSON, Alain | |
hal.structure.identifier | Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques [PECSA] | |
dc.contributor.author | DUPUIS, Vincent | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | SANDRE, Olivier | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1936-0851 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20000 | |
dc.description.abstractEn | Hydrophobically modified maghemite (γ-Fe2O3) nanoparticles were encapsulated within the membrane of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA) block copolymer vesicles using a nanoprecipitation process. This formation method gives a simple access to highly magnetic nanoparticles (MNPs) (loaded up to 70 wt %) together with a good control over the vesicles size (100 to 400 nm). The simultaneous loading of maghemite nanoparticles and doxorubicin was also achieved by nanoprecipitation. The deformation of the vesicle membrane under an applied magnetic field has been evidenced by small angle neutron scattering. These superparamagnetic hybrid self-assemblies display enhanced contrast properties that open potential applications for Magnetic Resonance Imaging. They can also be guided in a magnetic field gradient. The feasibility of controlled drug release by radio-frequency magnetic hyperthermia was demonstrated in the case of encapsulated doxorubicin molecules, showing the viability of the concept of magneto-chemotherapy. These magnetic polymersomes can be used as efficient multifunctional nano-carriers for combined therapy and imaging. | |
dc.language.iso | en | |
dc.publisher | American Chemical Society | |
dc.subject.en | block copolymer vesicles | |
dc.subject.en | polymersome | |
dc.subject.en | nanoprecipitation | |
dc.subject.en | superparamagnetic iron oxide nanoparticles | |
dc.subject.en | maghemite | |
dc.subject.en | magnetic hypethermia | |
dc.subject.en | magneto-chemotherapy | |
dc.subject.en | multifunctional | |
dc.subject.en | MRI contrast agent | |
dc.subject.en | doxorubicin | |
dc.subject.en | theranostics | |
dc.title.en | Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1021/nn102762f | |
dc.subject.hal | Chimie/Matériaux | |
dc.subject.hal | Chimie/Chimie thérapeutique | |
dc.description.sponsorshipEurope | Integration of Novel Nanoparticle based Technology for Therapeutics and Diagnosis of different types of Cancer | |
bordeaux.journal | ACS Nano | |
bordeaux.page | 1122-1140 | |
bordeaux.volume | 5 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.issue | 2 | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-00567258 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-00567258v1 | |
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