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Polymersome Shape Transformation at the Nanoscale

dc.rights.licenseopen
hal.structure.identifierLaboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire [LIONS]
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSALVA, Romain
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLE MEINS, Jean-Francois
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierLaboratoire Léon Brillouin [LLB - UMR 12]
dc.contributor.authorBRÛLET, Annie
hal.structure.identifierInstitut Charles Sadron [ICS]
dc.contributor.authorSCHMUTZ, Marc
hal.structure.identifierLaboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire [LIONS]
dc.contributor.authorGUENOUN, Patrick
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2013
dc.identifier.issn1936-0851
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19998
dc.description.abstractEnPolymer vesicles, also named polymersomes, are valuable candidates for drug delivery and micro or nano-reactors applications. As far as drug delivery is concerned, the shape of the carrier is believed to have a strong influence on the biodistribution and cell internalization. Polymersomes can be submitted to an osmotic imbalance when injected in physiological media leading to morphological changes. To understand these osmotic stress-induced variations in membrane properties and shapes, several nano-vesicles made of the graft polymer poly(dimethylsiloxane)-g-poly(ethylene oxide) (PDMS-g-PEO) or the triblock copolymer PEO-b-PDMS-b-PEO were osmotically stressed and observed by light scattering, neutron scattering (SANS) and cryo-transmission electron microscopy (cryo-TEM). Hypotonic shock leads to a swelling of the vesicles, comparable to optically observable giant polymersomes, and hypertonic shock leads to collapsed structures such as stomatocytes and original nested vesicles the latter being only observed for diblocks. Complementary SANS and cryo-TEM experiments are shown to be in quantitative agreement and highlight the importance of the membrane structure on the behavior of these nano-polymersomes under hypertonic conditions as the final morphology reached depends whether or not the copolymers assemble into a bilayer. The vesicle radius and membrane curvature are also shown to be critical parameters for such transformations: the shape evolution trajectory agrees with theoretical models only for large enough vesicle radii above a threshold value around four times the membrane thickness.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enpolymersomes
dc.subject.enshape transformation
dc.subject.enosmotic shock
dc.subject.envesicles
dc.subject.enblock copolymer
dc.subject.enbi-lamellar membrane
dc.subject.ennested vesicles
dc.subject.enpermeability
dc.title.enPolymersome Shape Transformation at the Nanoscale
dc.typeArticle de revue
dc.identifier.doi10.1021/nn4039589
dc.subject.halChimie/Matériaux
dc.subject.halChimie/Polymères
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
bordeaux.journalACS Nano
bordeaux.page9298 - 9311
bordeaux.volume7
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue10
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01904417
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01904417v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=ACS%20Nano&rft.date=2013&rft.volume=7&rft.issue=10&rft.spage=9298%20-%209311&rft.epage=9298%20-%209311&rft.eissn=1936-0851&rft.issn=1936-0851&rft.au=SALVA,%20Romain&LE%20MEINS,%20Jean-Francois&SANDRE,%20Olivier&BR%C3%9BLET,%20Annie&SCHMUTZ,%20Marc&rft.genre=article


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