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dc.rights.licenseopenen_US
dc.contributor.authorINITIATIVE, Covid- Host Genetics
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTREGOUET, David-Alexandre
dc.date.accessioned2024-05-21T07:46:56Z
dc.date.available2024-05-21T07:46:56Z
dc.date.issued2023-09-01
dc.identifier.issn1476-4687en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199944
dc.description.abstractEnInvestigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1,2 . Here we present a second updated genome-wide association study (GWAS) on COVID-19 severity and infection susceptibility to SARS-CoV-2 from the COVID-19 Host Genetic Initiative (data release 7). We performed a meta-analysis of up to 219,692 cases and over 3 million controls, identifying 51 distinct genome-wide significant loci—adding 28 loci from the previous data release 2 . The increased number of candidate genes at the identified loci helped to map three major biological pathways involved in susceptibility and severity: viral entry, airway defense in mucus, and type I interferon.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enA second update on mapping the human genetic architecture of COVID-19
dc.title.alternativeNatureen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41586-023-06355-3en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37674002en_US
bordeaux.journalNatureen_US
bordeaux.pageE7-E26en_US
bordeaux.volume621en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue7977en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature&rft.date=2023-09-01&rft.volume=621&rft.issue=7977&rft.spage=E7-E26&rft.epage=E7-E26&rft.eissn=1476-4687&rft.issn=1476-4687&rft.au=INITIATIVE,%20Covid-%20Host%20Genetics&DEBETTE,%20Stephanie&TREGOUET,%20David-Alexandre&rft.genre=article


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