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Mixing block copolymers with phospholipids at the nanoscale: from hybrid polymer/lipid worm-like micelles to vesicles presenting lipid nano-domains

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hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorTUYEN DAO, T. P.
hal.structure.identifierLaboratoire Léon Brillouin [LLB - UMR 12]
dc.contributor.authorBRÛLET, Annie
dc.contributor.authorFERNANDES, Fabio
hal.structure.identifierInstitut Charles Sadron [ICS]
dc.contributor.authorER-RAFIK, Meriem
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorFERJI, Khalid
hal.structure.identifierCentre de Recherche Paul Pascal [CRPP]
dc.contributor.authorCHAPEL, Jean-Paul
hal.structure.identifierInstitut Laue-Langevin [ILL]
dc.contributor.authorSCHWEINS, Ralf
dc.contributor.authorFEDOROV, Alexander
hal.structure.identifierInstitut Charles Sadron [ICS]
dc.contributor.authorSCHMUTZ, Marc
dc.contributor.authorPRIETO, Manuel
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLE MEINS, Jean-Francois
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2017
dc.identifier.issn0743-7463
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19992
dc.description.abstractEnHybrid, i.e. intimately mixed polymer/phospholipid vesicles can potentially marry in a single membrane the best characteristics of the two separate components. The ability of amphiphilic copolymers and phospholipids to self-assemble into hybrid membranes has been studied until now at the sub-micron scale using optical microscopy on Giant Hybrid Unilamellar Vesicles (GHUVs), but limited information is available on Large Hybrid Unilamellar Vesicles (LHUVs). In this work, copolymers based on poly(dimethyl siloxane) and poly(ethylene oxide) with different molar masses and architectures (graft, triblock) were associated with 1,2-di-palmitoyl-sn-glycero-3-phosphocholine (DPPC). Classical protocols of LUV formation were used to obtain nano-sized self-assembled structures. Using Small Angle Neutron Scattering (SANS), Time Resolved Förster Resonance Energy Transfer (TR-FRET) and Cryo-Transmission Electron Microscopy (Cryo-TEM), we show that copolymer architecture and molar mass have a direct consequence on the formation of hybrid nanostructures that can range from worm-like hybrid micelles to hybrid vesicles presenting small lipid nanodomains.
dc.description.sponsorshipCinétique de Translocation de Particules à travers de Bicouches Auto-Assemblées
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enlipid nanodomains
dc.subject.enHybrid Polymer Lipid Unilamellar Vesicle
dc.subject.enmembrane
dc.subject.enpolymersomes
dc.title.enMixing block copolymers with phospholipids at the nanoscale: from hybrid polymer/lipid worm-like micelles to vesicles presenting lipid nano-domains
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.langmuir.6b04478
dc.subject.halChimie/Polymères
dc.subject.halChimie/Chimie théorique et/ou physique
bordeaux.journalLangmuir
bordeaux.page1705-1715
bordeaux.volume33
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue7
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01448607
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01448607v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Langmuir&rft.date=2017&rft.volume=33&rft.issue=7&rft.spage=1705-1715&rft.epage=1705-1715&rft.eissn=0743-7463&rft.issn=0743-7463&rft.au=TUYEN%20DAO,%20T.%20P.&BR%C3%9BLET,%20Annie&FERNANDES,%20Fabio&ER-RAFIK,%20Meriem&FERJI,%20Khalid&rft.genre=article


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