TUYEN DAO, T. P.; BRÛLET, Annie; FERNANDES, Fabio; ER-RAFIK, Meriem; FERJI, Khalid; CHAPEL, Jean-Paul; SCHWEINS, Ralf; FEDOROV, Alexander; SCHMUTZ, Marc; PRIETO, Manuel; SANDRE, Olivier; LE MEINS, Jean-Francois

doi:10.1021/acs.langmuir.6b04478

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TUYEN DAO, T. P.
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

BRÛLET, Annie
Laboratoire Léon Brillouin [LLB - UMR 12]

FERNANDES, Fabio

Langue

Article de revue

Ce document a été publié dans

Langmuir. 2017, vol. 33, n° 7, p. 1705-1715

American Chemical Society

Résumé en anglais

Hybrid, i.e. intimately mixed polymer/phospholipid vesicles can potentially marry in a single membrane the best characteristics of the two separate components. The ability of amphiphilic copolymers and phospholipids to self-assemble into hybrid membranes has been studied until now at the sub-micron scale using optical microscopy on Giant Hybrid Unilamellar Vesicles (GHUVs), but limited information is available on Large Hybrid Unilamellar Vesicles (LHUVs). In this work, copolymers based on poly(dimethyl siloxane) and poly(ethylene oxide) with different molar masses and architectures (graft, triblock) were associated with 1,2-di-palmitoyl-sn-glycero-3-phosphocholine (DPPC). Classical protocols of LUV formation were used to obtain nano-sized self-assembled structures. Using Small Angle Neutron Scattering (SANS), Time Resolved Förster Resonance Energy Transfer (TR-FRET) and Cryo-Transmission Electron Microscopy (Cryo-TEM), we show that copolymer architecture and molar mass have a direct consequence on the formation of hybrid nanostructures that can range from worm-like hybrid micelles to hybrid vesicles presenting small lipid nanodomains.< Réduire

Mots clés en anglais

lipid nanodomains

Hybrid Polymer Lipid Unilamellar Vesicle

membrane

polymersomes

URI

https://oskar-bordeaux.fr/handle/20.500.12278/19992

DOI

http://dx.doi.org/10.1021/acs.langmuir.6b04478

Project ANR

Cinétique de Translocation de Particules à travers de Bicouches Auto-Assemblées

Origine

Importé de hal

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629