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Phase Separation and Nanodomain Formation in Hybrid Polymer/Lipid Vesicles

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorTUYEN DAO, T. P.
dc.contributor.authorFERNANDES, Fabio
hal.structure.identifierInstitut Charles Sadron [ICS]
dc.contributor.authorER-RAFIK, Meriem
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSALVA, Romain
hal.structure.identifierInstitut Charles Sadron [ICS]
dc.contributor.authorSCHMUTZ, Marc
hal.structure.identifierLaboratoire Léon Brillouin [LLB - UMR 12]
dc.contributor.authorBRÛLET, Annie
dc.contributor.authorPRIETO, Manuel
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLE MEINS, Jean-Francois
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2015
dc.identifier.issn2161-1653
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19991
dc.description.abstractEnHybrid polymer/lipid large unilamellar vesicles (LUVS) were studied by small angle neutron scattering (SANS), time-resolved Forster resonance energy transfer (TR-FRET), and cryo-transmission electron microscopy (cryo-TEM). For the first time in hybrid vesicles, evidence for phase separation at the nanoscale was obtained, leading to the formation of stable nanodomains enriched either in lipid or polymer. This stability was allowed by using vesicle-forming copolymer with a membrane thickness dose to the lipid bilayer thickness, thereby minimizing the hydrophobic mismatch at the domain periphery. Hybrid giant unilamellar vesicles (GUVs) with the same composition have been previously shown to be unstable and susceptible to fission, suggesting a role of curvature in the stabilization of nanodomains in these structures.
dc.description.sponsorshipCinétique de Translocation de Particules à travers de Bicouches Auto-Assemblées - ANR-12-BS08-0018
dc.language.isoen
dc.publisherWashington, D.C : American Chemical Society
dc.subject.enLIPID MEMBRANES
dc.subject.enFluorescence resonance energy transfer FRET
dc.subject.enMEMBRANE COMPOSITION
dc.subject.enLINE TENSION
dc.subject.enRAFTS
dc.subject.enNANODOMAINS
dc.subject.enMICELLES
dc.subject.enHybrid membranes
dc.subject.enLIPID-POLYMER BLENDS
dc.title.enPhase Separation and Nanodomain Formation in Hybrid Polymer/Lipid Vesicles
dc.typeArticle de revue
dc.identifier.doi10.1021/mz500748f
dc.subject.halChimie/Polymères
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
bordeaux.journalACS Macro Letters
bordeaux.page182-186
bordeaux.volume4
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue2
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01383233
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01383233v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=ACS%20Macro%20Letters&rft.date=2015&rft.volume=4&rft.issue=2&rft.spage=182-186&rft.epage=182-186&rft.eissn=2161-1653&rft.issn=2161-1653&rft.au=TUYEN%20DAO,%20T.%20P.&FERNANDES,%20Fabio&ER-RAFIK,%20Meriem&SALVA,%20Romain&SCHMUTZ,%20Marc&rft.genre=article


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