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Psychotropic drugs in mixture alter swimming behaviour of Japanese medaka (Oryzias latipes) larvae above environmental concentrations

hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorCHIFFRE, Axelle
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorCLERENDEAU, Christelle
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorDWOINIKOFF, Charline
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorLE BIHANIC, Florane
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBUDZINSKI, Hélène
ORCID: 0000-0003-1028-9154
IDREF: 070478090
hal.structure.identifierInstitut national universitaire Champollion [Albi] [INUC]
hal.structure.identifierGéographie de l'environnement [GEODE]
dc.contributor.authorGERET, Florence
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorCACHOT, Jérôme
ORCID: 0000-0002-1492-9684
IDREF: 19667672X
dc.date.accessioned2024-05-15T12:03:11Z
dc.date.available2024-05-15T12:03:11Z
dc.date.issued2016-03
dc.identifier.issn0944-1344
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199874
dc.description.abstractEnPsychiatric pharmaceuticals, such as anxiolytics, sedatives, hypnotics and antidepressors, are among the most prescribed active substances in the world. The occurrence of these compounds in the environment, as well as the adverse effects they can have on non-target organisms, justifies the growing concern about these emerging environmental pollutants. This study aims to analyse the effects of six psychotropic drugs, valproate, cyamemazine, citalopram, sertraline, fluoxetine and oxazepam, on the survival and locomotion of Japanese medaka Oryzias latipes larvae. Newly hatched Japanese medaka were exposed to individual compounds for 72 h, at concentrations ranging from 10 μg L−1 to 10 mg L−1. Lethal concentrations 50 % (LC50) were estimated at 840, 841 and 9,136 μg L−1 for fluoxetine, sertraline and citalopram, respectively, while other compounds did not induce any significant increase in mortality. Analysis of the swimming behaviour of larvae, including total distance moved, mobility and location, provided an estimated lowest observed effect concentration (LOEC) of 10 μg L−1 for citalopram and oxazepam, 12.2 μg L−1 for cyamemazine, 100 μg L−1 for fluoxetine, 1,000 μg L−1 for sertraline and >10,000 μg L−1 for valproate. Realistic environmental mixture of the six psychotropic compounds induced disruption of larval locomotor behaviour at concentrations about 10- to 100-fold greater than environmental concentrations.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject.enVideo tracking
dc.subject.enLocomotor activity
dc.subject.enPsychotropics
dc.subject.enEnvironmental risk evaluation
dc.subject.enJapanese medaka
dc.title.enPsychotropic drugs in mixture alter swimming behaviour of Japanese medaka (Oryzias latipes) larvae above environmental concentrations
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s11356-014-3477-4
dc.subject.halSciences du Vivant [q-bio]/Toxicologie/Ecotoxicologie
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques/Médicaments
dc.subject.halSciences de l'environnement/Biodiversité et Ecologie
bordeaux.journalEnvironmental Science and Pollution Researchen_US
bordeaux.page4964-4977
bordeaux.volume23
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue6
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
bordeaux.import.sourcehal
hal.identifierhal-01864816
hal.version1
hal.popularnon
hal.audienceInternationale
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Science%20and%20Pollution%20Research&rft.date=2016-03&rft.volume=23&rft.issue=6&rft.spage=4964-4977&rft.epage=4964-4977&rft.eissn=0944-1344&rft.issn=0944-1344&rft.au=CHIFFRE,%20Axelle&CLERENDEAU,%20Christelle&DWOINIKOFF,%20Charline&LE%20BIHANIC,%20Florane&BUDZINSKI,%20H%C3%A9l%C3%A8ne&rft.genre=article


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